#ube3a — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #ube3a, aggregated by home.social.
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"Finally, we show that (S)-PHA533533 unsilences paternal UBE3A in Angelman syndrome (AS) patient-derived neurons, highlighting its translational potential. Our findings provide a lead for developing a small molecule treatment for AS that could be safe, non-invasively delivered, and capable of brain-wide unsilencing of paternal #UBE3A."
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Adult Angelman mice get some benefit from boosting UBE3A gene expression
https://www.spectrumnews.org/news/adult-angelman-mice-get-some-benefit-from-boosting-ube3a-gene-expression/
#Angelmansyndrome #clinicaltrials #geneexpression #animalmodels #genetherapy #mousemodels #treatments #autism #sleep #UBE3A #News #EEG -
Beyond the bench: Finding solitude with Jill Silverman
https://www.spectrumnews.org/opinion/q-and-a/beyond-the-bench-finding-solitude-with-jill-silverman/
#Angelmansyndrome #mousemodels #autism #UBE3A #QA -
Promising preclinical results prompt Angelman therapy trial
https://www.spectrumnews.org/news/promising-preclinical-results-prompt-angelman-therapy-trial/
#Angelmansyndrome #clinicaltrials #genetherapy #treatments #monkeys #autism #UBE3A #News -
Angelman therapy appears safer in restarted trial
https://www.spectrumnews.org/news/angelman-therapy-appears-safer-in-restarted-trial/
#Angelmansyndrome #clinicaltrials #genetherapy #treatments #autism #UBE3A #News -
Enrichment lessens Angelman-like traits in male mice
https://www.spectrumnews.org/news/enrichment-lessens-angelman-like-traits-in-male-mice/
#Angelmansyndrome #environment #motorskills #mousemodels #UBE3A #News #sex -
One-shot gene therapy for Angelman syndrome shows promise in mice
https://www.spectrumnews.org/news/one-shot-gene-therapy-for-angelman-syndrome-shows-promise-in-mice/
#Angelmansyndrome #hippocampus #mousemodels #treatments #15q11-13 #autism #UBE3A #News -
Dispatches from SfN 2021: Mitochondria, Rett therapy and oxytocin
https://www.spectrumnews.org/news/dispatches-from-sfn-2021-mitochondria-rett-therapy-and-oxytocin/
#Prader-Willisyndrome #synapticplasticity #Angelmansyndrome #geneexpression #socialdeficits #connectivity #mitochondria #Rettsyndrome #mousemodels #treatments #15q11-13 #autism #SHANK3 #MECP2 #SCN2A #UBE3A #News #ANK2 #sex -
Paused Angelman syndrome trial to restart
https://www.spectrumnews.org/news/paused-angelman-syndrome-trial-to-restart/
#Angelmansyndrome #clinicaltrials #genetherapy #treatments #UBE3A #News