#transcriptional — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #transcriptional, aggregated by home.social.
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🍅Welcome back to #TomatoTuesday!🍅
In a new #JIPB paper,🍅He et al. report that two🍅members of the APETALA2🍅family mediate a🍅🍅#transcriptional cascade that orchestrates #carotenoid #biosynthesis🍅in #tomato.
https://doi.org/10.1111/jipb.13650🍅
@wileyplantsci
#PlantSci🍅#lycopene #fruit #botany -
Uncovering the role of #FOXO1 in #vascular #development and #transcriptional dynamics in #endothelial cells.
https://phys.org/news/2024-03-uncovering-role-foxo1-vascular-transcriptional.html
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When we say this paper is hot...🔥
Zhu et al. find that #Arabidopsis NFXL1 functions as a #transcriptional activator required for reproductive #thermotolerance.
https://doi.org/10.1111/jipb.13604
@wileyplantsci
#JIPB #PlantScience #botany -
#Transcriptional memory through chromatin modification is a fascinating phenomenon. A naive view of how this happens is that transcriptional activators can persist, as stable proteins, over several cellular doublings, as demonstrated for the Gal4 activator in yeast. However, it looks like chromatin modifications can be persistent in the absence of transcription, as this recent pre-print seem to demonstrate:
https://biologists.social/@biorxivpreprint/111592887255295543
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Unearthing the terroir effect: #Grapevine's #transcriptional response to #soil variability.
#genotype #environment #RNAseq #transcriptional_plasticity
https://phys.org/news/2023-11-unearthing-terroir-effect-grapevine-transcriptional.html
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#Amyloid protein assemblies can be toxic, but are some also of use to cells?
Diana Ottoz, Luke Berchowitz et al show that assembly of yeast #RNA-binding protein #Rim4 occurs reversibly in response to nutrient stimuli and mediates its #transcriptional #repressor function -
Researchers reveal a unique, hitherto-unknown #bacterial #transcriptional #promoter recognition mode.
#clostridium #SigI #RNAP #lignocellulose
https://phys.org/news/2023-10-reveal-unique-hitherto-unknown-bacterial-transcriptional.html
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"Consequently, STING-deficient DCs display reduced NF-κB activation and subsequent defects in #transcriptional induction and functional production of interleukin-1β (IL-1β) and IL-6 following their interaction with T_EM #cells. The discovery of T_EM cell-induced innate inflammation through #DNA damage and a non-canonical STING-NF-κB pathway presents this pathway as a potential target to alleviate T cell-driven #inflammation in #autoimmunity and #cytokine storms."
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Last session of the conference! Continuing theme of "Cell identity in situ"
Parker Côté, DFCI
in Li Lab
https://ki.mit.edu/people/clinical-investigators-research-fellows/hojun-liThe #transcriptional dynamics of human #hematopoiesis at #SingleCell resolution
do #StemCells and #ProgenitorCells in #hematopoietic system (#HSPC) change with age?
HSPCs exist on a continuum of cell types
They identified #GeneExpression programs active in uncommitted cells, looking across human development (fetal to aged)
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in #cancer cells, resistance can arise due to non-genetic differences
Emergent resistant colonies can represent various fate outcomes
--want to know where they came fromhttps://pubmed.ncbi.nlm.nih.gov/37468627/
single cell analysis reveals #transcriptional diversity in drug resistant fates, even within individual clones
but see "memory" in resistant states (drug treatment)
2/2
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Loic Binan of the Broad:
All-optical genetic screens of intracellular and intercellular #transcriptional circuits with Perturb-FISHVarious CRISPR-based methods to look (multiplexed) at outcomes after knockdown to explore gene expression circuits, those are great, but want richer data (morphology etc)
one guide per cell (knock down one gene per cell) see #transcriptome via MERFISH, then identify the perturbed gene via in situ T7 transcription (same chemistry as MERFISH)
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"Pharmacological YAP activation enacts a reversible pro-proliferative #transcriptional program in #keratinocytes and #dermal cells that results in accelerated re-epithelization and regranulation of the #wound bed. These results demonstrate that transient topical administration of a YAP activating agent may represent a generalizable $therapeutic approach to treating cutaneous wounds."
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<checks calendar> Sunday?
🍅Perfect day to talk 🍅#tomatoes with Shi et al. who🍅review #transcriptional regulation of 🍅processes related to 🍅fleshy #fruit texture🔓⬇️🍅https://jipb.net/EN/10.1111/jipb.13316
@wileyplantsci
🍅 #PlantSci #development 🍅#CellWall #TF #PlantScience #MADSBoxProtein -
K27 crotonylation - Another regulatory modification on Lysine 27 of #histone H3. Read:
Histone H3 lysine 27 crotonylation mediates gene #transcriptional repression in #chromatin
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"By targeted mutations and overexpression of YAP/TAZ, we show that this #mechanobiological #regulation, which also impacts core components of the clock such as Bmal1 and Cry1, depends on the binding of YAP/TAZ to the #transcriptional effector TEAD. This mechanism could explain the impairment of #circadian rhythms observed when YAP/TAZ activity is upregulated, as in #cancer and #aging.
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Shamless plug warning! ⚠️
Our last paper on #transcriptional heterogeneity of #pediatric #cancer is out.
Did you think a quiet #genome translates into a quiet #transcriptome? Think again!#multiscale #clustering on a pan-cancer #RNASeq cohort revealed new diagnostic subtypes and helped us train a #cnn model to identify tumour components in #clinical #oncology samples.
Read it here, it's #openaccess: https://www.nature.com/articles/s41591-023-02221-x
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PIF7-mediated #epigenetic reprogramming promotes the #transcriptional response to shade in #Arabidopsis
Chuanwei Yang et al.find when a plant grows in shade, transcription factor PIF7 triggers the adaptive growth response by guiding H3.3 deposition via the #histone chaperone #ASF1
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#Transcriptional adaptation found to play a role in inherited #epigenetic changes.
https://phys.org/news/2022-12-transcriptional-play-role-inherited-epigenetic.html
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Insightful overview of where the field of blood biomarkers to diagnose infections is heading.
🎯 are all patients easily categorizable into bacterial or viral? (almost certainly 👎)
🎯 should we be aiming towards probability scores for different infection classes? (likely👍)
🎯will anything beat CRP or PCT in helping reduce unnecessary antibiotic prescriptions? 🤷#transcriptional #biomarkers #viral #bacterial #blood #IDMastodon #MedMastodon
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00430-X?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS266637912200430X%3Fshowall%3Dtrue -
@edwardlau fantastic, #phosphoproteomics and #transcriptional profiling kinetics of #chromatin remodeling ?
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Here's my #introduction -
#Scientist and Associate Professor at the Department of Molecular and Cellular Physiology, Albany Medical College.
I research the mechanisms of #vascular #dysfunction leading to organ damage during severe #inflammation (e.g. #sepsis and septic #shock ) and its sequelae ( #kidney damage, #CognitiveDysfunction ). Working to find ways to prevent this by tackling the changes in the #endothelium. Interested in all things #signal #transduction and #transcriptional regulation
