#tpdwebinar — Public Fediverse posts

Very interesting talk by Kyle Mangano of Amgen at the Dana-Farber Targeted Protein Degradation Webinar #TPD #TPDWebinar. He talked about his work on hijacking viral E3 ligases for targeted protein degradation using the VIPER-TAC modality. https://www.biorxiv.org/content/10.1101/2024.08.13.607762v1

Interesting talk by Liron Bar-Peled at #TPDWebinar. He talked about his group's work on expanding the druggable proteome in cancers by using chemoproteomics to profile ligandable cysteines. Interesting insights into ligandability across diverse cancers. https://www.sciencedirect.com/science/article/abs/pii/S0092867424003180
Interesting results also on molecules with two cysteine-directed reactive groups that act as molecular superglues that permanently link together two proteins. https://www.biorxiv.org/content/10.1101/2024.07.16.603666v1

Interesting talk by Pamela Ting from Novartis at #TPDWebinar. She talked about the application of degraders in the field of Sickle cell disease. They identified a degrader for the transcription factor WIZ that leads to induction of fetal hemoglobin https://www.sciencedirect.com/science/article/abs/pii/S0006497123735398

Interesting talk by Samantha Bevill at #TPDWebinar. She talked about her research into developing tumor-specific PROTACs on the example of engaging the E3 ubiquitin ligase MDM2 to specifically degrade proteins in MDM2-amplified cancer cells. https://www.cell.com/cell-genomics/fulltext/S2666-979X(23)00089-7

The Dana Farber Targeted Protein Degradation #TPDWebinar is off to a great start with an insightful talk by Eric Fischer. He talked about his group's work on the functional targets of thalidomide and how to identify new (covalent) molecular glues. https://www.nature.com/articles/s41589-024-01668-4

Join us tomorrow for Mikko Taipale #TPDwebinar 12:00 noon EST. Register to join via zoom at https://www.danafarbertargetedproteindegradation.org/