#tlr4 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #tlr4, aggregated by home.social.
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interesting comment from Dr Younger:
"Thanks for bringing up that issue! There has been a ton of misinformation on "regular" prescription naltrexone, even among experts. If you look it up on Google, it will tell you that naltrexone is a racemic mixture of l- and d- forms. Any many, if not most, papers do the same. They are all wrong. If you pull up the CoA for manufactured naltrexone, you will see it has a -192 degree optical rotation. All commercial naltrexone is levo only. Levo hits both opioid and TLR4 receptors (among other things), while dextro only hits the TLR4 receptor. I don't know how to fix the misinformation online because now AI is pulling its info from incorrect sources. So it is almost impossible to get to the right source unless someone already knows what they are doing (e.g., accessing the manufacturer CoA's). - Jarred Younger"
https://www.youtube.com/watch?v=KpsK6RmqLNI&lc=Ugz8z9zuskpLiMGay-N4AaABAg.APdUyq5hqymAPdY5kV5qVu
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interesting comment from Dr Younger:
"Thanks for bringing up that issue! There has been a ton of misinformation on "regular" prescription naltrexone, even among experts. If you look it up on Google, it will tell you that naltrexone is a racemic mixture of l- and d- forms. Any many, if not most, papers do the same. They are all wrong. If you pull up the CoA for manufactured naltrexone, you will see it has a -192 degree optical rotation. All commercial naltrexone is levo only. Levo hits both opioid and TLR4 receptors (among other things), while dextro only hits the TLR4 receptor. I don't know how to fix the misinformation online because now AI is pulling its info from incorrect sources. So it is almost impossible to get to the right source unless someone already knows what they are doing (e.g., accessing the manufacturer CoA's). - Jarred Younger"
https://www.youtube.com/watch?v=KpsK6RmqLNI&lc=Ugz8z9zuskpLiMGay-N4AaABAg.APdUyq5hqymAPdY5kV5qVu
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interesting comment from Dr Younger:
"Thanks for bringing up that issue! There has been a ton of misinformation on "regular" prescription naltrexone, even among experts. If you look it up on Google, it will tell you that naltrexone is a racemic mixture of l- and d- forms. Any many, if not most, papers do the same. They are all wrong. If you pull up the CoA for manufactured naltrexone, you will see it has a -192 degree optical rotation. All commercial naltrexone is levo only. Levo hits both opioid and TLR4 receptors (among other things), while dextro only hits the TLR4 receptor. I don't know how to fix the misinformation online because now AI is pulling its info from incorrect sources. So it is almost impossible to get to the right source unless someone already knows what they are doing (e.g., accessing the manufacturer CoA's). - Jarred Younger"
https://www.youtube.com/watch?v=KpsK6RmqLNI&lc=Ugz8z9zuskpLiMGay-N4AaABAg.APdUyq5hqymAPdY5kV5qVu
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interesting comment from Dr Younger:
"Thanks for bringing up that issue! There has been a ton of misinformation on "regular" prescription naltrexone, even among experts. If you look it up on Google, it will tell you that naltrexone is a racemic mixture of l- and d- forms. Any many, if not most, papers do the same. They are all wrong. If you pull up the CoA for manufactured naltrexone, you will see it has a -192 degree optical rotation. All commercial naltrexone is levo only. Levo hits both opioid and TLR4 receptors (among other things), while dextro only hits the TLR4 receptor. I don't know how to fix the misinformation online because now AI is pulling its info from incorrect sources. So it is almost impossible to get to the right source unless someone already knows what they are doing (e.g., accessing the manufacturer CoA's). - Jarred Younger"
https://www.youtube.com/watch?v=KpsK6RmqLNI&lc=Ugz8z9zuskpLiMGay-N4AaABAg.APdUyq5hqymAPdY5kV5qVu
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078 - How I am going to fight brain inflammation | Jarred Younger, PhD
uploaded Nov 17, 2025
https://youtu.be/KpsK6RmqLNIDr. Younger shares his intention to manufacture and test dextro-naltrexone in a clinical trial.
😀
#naltrexone #LDN #DextroNaltrexone #neroinflammation #neuroscience #immunology #MECFS #TLR4
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078 - How I am going to fight brain inflammation | Jarred Younger, PhD
uploaded Nov 17, 2025
https://youtu.be/KpsK6RmqLNIDr. Younger shares his intention to manufacture and test dextro-naltrexone in a clinical trial.
😀
#naltrexone #LDN #Dextro-Naltrexone #neroinflammation #neuroscience #immunology #MECFS #TLR4
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078 - How I am going to fight brain inflammation | Jarred Younger, PhD
uploaded Nov 17, 2025
https://youtu.be/KpsK6RmqLNIDr. Younger shares his intention to manufacture and test dextro-naltrexone in a clinical trial.
😀
#naltrexone #LDN #DextroNaltrexone #neroinflammation #neuroscience #immunology #MECFS #TLR4
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078 - How I am going to fight brain inflammation | Jarred Younger, PhD
uploaded Nov 17, 2025
https://youtu.be/KpsK6RmqLNIDr. Younger shares his intention to manufacture and test dextro-naltrexone in a clinical trial.
😀
#naltrexone #LDN #DextroNaltrexone #neroinflammation #neuroscience #immunology #MECFS #TLR4
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078 - How I am going to fight brain inflammation | Jarred Younger, PhD
uploaded Nov 17, 2025
https://youtu.be/KpsK6RmqLNIDr. Younger shares his intention to manufacture and test dextro-naltrexone in a clinical trial.
😀
#naltrexone #LDN #DextroNaltrexone #neroinflammation #neuroscience #immunology #MECFS #TLR4
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Repetitive transcranial magnetic stimulation alleviates glial activation through suppressing HMGB1/TLR4 pathway in a rat model of Parkinson’s disease [2023]
https://doi.org/10.1007/s11033-023-08561-8"This study showed that rTMS might be a promising method for alleviating neuroinflammation in PD rat models, and the effects might be mediated through the downregulation of the HMGB1/TLR4 pathway."
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Repetitive transcranial magnetic stimulation alleviates glial activation through suppressing HMGB1/TLR4 pathway in a rat model of Parkinson’s disease [2023]
https://doi.org/10.1007/s11033-023-08561-8"This study showed that rTMS might be a promising method for alleviating neuroinflammation in PD rat models, and the effects might be mediated through the downregulation of the HMGB1/TLR4 pathway."
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Repetitive transcranial magnetic stimulation alleviates glial activation through suppressing HMGB1/TLR4 pathway in a rat model of Parkinson’s disease [2023]
https://doi.org/10.1007/s11033-023-08561-8"This study showed that rTMS might be a promising method for alleviating neuroinflammation in PD rat models, and the effects might be mediated through the downregulation of the HMGB1/TLR4 pathway."
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Repetitive transcranial magnetic stimulation alleviates glial activation through suppressing HMGB1/TLR4 pathway in a rat model of Parkinson’s disease [2023]
https://doi.org/10.1007/s11033-023-08561-8"This study showed that rTMS might be a promising method for alleviating neuroinflammation in PD rat models, and the effects might be mediated through the downregulation of the HMGB1/TLR4 pathway."
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Makes me wonder if the relationship between asthma prevalence and latitude is is mediated by TLR4 activation, in addition to or instead of vitamin D levels.
Asthma Prevalence Associated with Geographical Latitude and Regional Insolation in the United States of America and Australia [2011]
https://doi.org/10.1371/journal.pone.0018492Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4 [2014]
https://synapse.koreamed.org/articles/1022548 -
Near Infrared Light Reduces Inflammation via TLR4 In Vitro [2022]
https://youtu.be/e6xj14QYsocvideo discusses this article:
Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
https://pmc.ncbi.nlm.nih.gov/articles/PMC8451450/"The inflammatory response was induced in cell cultures by LPS, followed by exposure to 720 nm LED light source at an intensity of 6 W/m2 for 10 min at 12-h intervals (see methods). ... At the end of the 48-h treatment period, cells were harvested and gene expression analysis performed. The results showed an approximately 50% reduction in gene expression of all of these markers in response to LED infrared exposure (Figure 4). ..."
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Near Infrared Light Reduces Inflammation via TLR4 In Vitro [2022]
https://youtu.be/e6xj14QYsocvideo discusses this article:
Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
https://pmc.ncbi.nlm.nih.gov/articles/PMC8451450/"The inflammatory response was induced in cell cultures by LPS, followed by exposure to 720 nm LED light source at an intensity of 6 W/m2 for 10 min at 12-h intervals (see methods). ... At the end of the 48-h treatment period, cells were harvested and gene expression analysis performed. The results showed an approximately 50% reduction in gene expression of all of these markers in response to LED infrared exposure (Figure 4). ..."
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Near Infrared Light Reduces Inflammation via TLR4 In Vitro [2022]
https://youtu.be/e6xj14QYsocvideo discusses this article:
Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
https://pmc.ncbi.nlm.nih.gov/articles/PMC8451450/"The inflammatory response was induced in cell cultures by LPS, followed by exposure to 720 nm LED light source at an intensity of 6 W/m2 for 10 min at 12-h intervals (see methods). ... At the end of the 48-h treatment period, cells were harvested and gene expression analysis performed. The results showed an approximately 50% reduction in gene expression of all of these markers in response to LED infrared exposure (Figure 4). ..."
-
Near Infrared Light Reduces Inflammation via TLR4 In Vitro [2022]
https://youtu.be/e6xj14QYsocvideo discusses this article:
Infrared light therapy relieves TLR-4 dependent hyper-inflammation of the type induced by COVID-19
https://pmc.ncbi.nlm.nih.gov/articles/PMC8451450/"The inflammatory response was induced in cell cultures by LPS, followed by exposure to 720 nm LED light source at an intensity of 6 W/m2 for 10 min at 12-h intervals (see methods). ... At the end of the 48-h treatment period, cells were harvested and gene expression analysis performed. The results showed an approximately 50% reduction in gene expression of all of these markers in response to LED infrared exposure (Figure 4). ..."
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A synthetic #TLR4 agonist significantly increases #humoral immune #responses and the protective ability of an #MDCK-cell-derived inactivated #H7N9 #vaccine in #mice, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06082-8
Antigenically divergent H7N9 viruses pose a potential threat to public #health, with the poor #immunogenicity of candidate H7N9 vaccines demonstrated in clinical trials underscoring the urgent need for more-effective H7N9 vaccines.
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A synthetic #TLR4 agonist significantly increases #humoral immune #responses and the protective ability of an #MDCK-cell-derived inactivated #H7N9 #vaccine in #mice, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06082-8
Antigenically divergent H7N9 viruses pose a potential threat to public #health, with the poor #immunogenicity of candidate H7N9 vaccines demonstrated in clinical trials underscoring the urgent need for more-effective H7N9 vaccines.
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A synthetic #TLR4 agonist significantly increases #humoral immune #responses and the protective ability of an #MDCK-cell-derived inactivated #H7N9 #vaccine in #mice, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06082-8
Antigenically divergent H7N9 viruses pose a potential threat to public #health, with the poor #immunogenicity of candidate H7N9 vaccines demonstrated in clinical trials underscoring the urgent need for more-effective H7N9 vaccines.
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A synthetic #TLR4 agonist significantly increases #humoral immune #responses and the protective ability of an #MDCK-cell-derived inactivated #H7N9 #vaccine in #mice, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06082-8
Antigenically divergent H7N9 viruses pose a potential threat to public #health, with the poor #immunogenicity of candidate H7N9 vaccines demonstrated in clinical trials underscoring the urgent need for more-effective H7N9 vaccines.
-
A synthetic #TLR4 agonist significantly increases #humoral immune #responses and the protective ability of an #MDCK-cell-derived inactivated #H7N9 #vaccine in #mice, Arch Virol.: https://link.springer.com/article/10.1007/s00705-024-06082-8
Antigenically divergent H7N9 viruses pose a potential threat to public #health, with the poor #immunogenicity of candidate H7N9 vaccines demonstrated in clinical trials underscoring the urgent need for more-effective H7N9 vaccines.