#swisnf — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #swisnf, aggregated by home.social.
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Very interesting counteracting functions of SWI/SNF and NuRD complexes, countering versus favouring Polycomb-mediating repression at bivalent genes. On the other hand, SWI/SNF maintains high level of promoter-proximal Pol II, whereas NuRD rather increases its constant release into the gene body
The impact of #swisnf and NuRD inactivation on
gene expression is tightly coupled with levels of RNA
#polymerase II occupancy at #promoters
https://genome.cshlp.org/cgi/content/long/gr.277089.122v1
@genomeresearch -
A #oncohistone, #Polycomb #SWISNF interplay provides a possible avenue for treatment of #pediatric gliomas: #BAF Complex Maintains #Glioma Stem Cells in Pediatric #H3K27M #Glioma - https://doi.org/10.1158/2159-8290.CD-21-1491 @CD_AACR