#substitutions — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #substitutions, aggregated by home.social.
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microRNApro.com launch (3) Grok Tragic VA clinic shooting in Jasper involving Nicholas Crews and Lawrence Michels. No evidence links my responses or any “examples of human idiocy” to these deat...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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microRNApro.com launch (1) Grok Those papers reveal key miRNA dynamics: pH-driven protonation reshapes pre-miR-21 for enhanced Dicer processing, while miRNAs coordinate gene fluctuations into stabl...
#Adaptations #amino #acid #substitutions #biodiversity #natural #selection #RNA-mediated #supercoiled #DNA #viral
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microRNApro.com launch Grok Those papers reveal key miRNA dynamics: pH-driven protonation reshapes pre-miR-21 for enhanced Dicer processing, while miRNAs coordinate gene fluctuations into stable st...
#Adaptations #amino #acid #substitutions #biodiversity #natural #selection #RNA-mediated #supercoiled #DNA #viral
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microRNApro.com launch Grok Those papers reveal key miRNA dynamics: pH-driven protonation reshapes pre-miR-21 for enhanced Dicer processing, while miRNAs coordinate gene fluctuations into stable st...
#Adaptations #amino #acid #substitutions #biodiversity #natural #selection #RNA-mediated #supercoiled #DNA #viral
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microRNApro.com launch Grok Those papers reveal key miRNA dynamics: pH-driven protonation reshapes pre-miR-21 for enhanced Dicer processing, while miRNAs coordinate gene fluctuations into stable st...
#Adaptations #amino #acid #substitutions #biodiversity #natural #selection #RNA-mediated #supercoiled #DNA #viral
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Grok’s war casualties (1) Did the WHO and/or Grok not know that Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene 9/2/11 linked Micr...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Galactic feedback & earthly delights (5) Kohl “Galactic feedback & earthly delights (4)” “Genetically Modified Microorganisms Can Collapse Ecosystems…Anyone Can Create Them” 3/2/2...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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miRNA-mediated molecular distance (7) supports precision medicine by helping tailor treatments based on individual genetics—available at no cost through VA care for qualified honorably discharged...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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miRNA-mediated molecular distance (7) supports precision medicine by helping tailor treatments based on individual genetics—available at no cost through VA care for qualified honorably discharged...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Stellar energy (1) “Biophysically constrained life (10)” “Grok’s claim about fluctuating light and organ-specific responses relevant to ecology, health, and evolution across species appears...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Biophysically constrained life (9) On 2/7/26 Grok wrote James V. Kohl, a researcher focused on miRNA-mediated biophysical constraints on life, uses this post to extend his ongoing series critiquing...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Biophysically constrained life (7) Biophysically constrained life (6) “Have injections with modified mRNA been linked to failed miRNA-mediated DNA repair via energy-dependent RNA-directed DNA met...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Biophysically constrained life (6) Biophysically constrained life (5) Photosynthesis links electron transport from energy-dependent changes in molecular distance to all biodiversity on Earth, via N...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Biophysically constrained life (4) All cell type differentiation in all individuals of all species is miRNA-mediated and biophysically constrained by the pH-dependent physiology of reproduction. Pe...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Giants of science vs mental midgets (6) See first: Giants of science vs mental midgets (5) Grok Scientific consensus dates Earth to ~4.5 billion years, with evolution over billions (e.g., sources l...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Prove us wrong (9) Intercalated bacterial biofilms are intrinsic internal components of calcium-based kidney stones 1/26/26 Reported by Science and Astronomy as: For decades, doctors believed the m...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Light-activated miRNA abundance (5) “Light-activated miRNA abundance (4)” “By showing how this hidden capability can be used to perform precise mathematical operations, the work suggests that...
#Adaptations #What's #in #the #News #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled
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“Light-activated miRNA abundance (5) “Light-activated miRNA abundance (4)” “By showing how this hidden capability can be used to perform precise mathematical operations, the work suggests t...
#Adaptations #What's #in #the #News #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled
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Biophysically nuanced life (4) Kohl Re: “I don’t agree that focusing on empirical data caused the pandemic or related suffering.” @Grok I’m certain President Trump and other intelligent peo...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Biophysically nuanced life (3) GrokI’m open to exploring your perspective on miRNA-driven models. From diverse sources, miRNAs likely evolved from siRNA pathways in eukaryotes ~600-800 million ye...
#Adaptations #amino #acid #substitutions #biodiversity #natural #selection #RNA-mediated #supercoiled #DNA #viral
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Energy-dependent quantum coherence (2) Grok Red light, via phytochromes and photobiomodulation, influences ATP production and cellular signaling, potentially affecting energy-dependent amino acid s...
#Adaptations #amino #acid #substitutions #biodiversity #natural #selection #RNA-mediated #supercoiled #DNA #viral
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Energy-dependent quantum coherence (1) From Grok vs quantum coherence (10) Grok wrote: “pairwise connections exist: miR-21 regulates autophagy in cancers (e.g., PubMed studies), and microtubules ...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Grok vs quantum coherence (6) From Grok vs quantum coherence (5) “miRNAs regulate pH-dependent processes like autophagy” See: Circular RNA SETD2 (circSETD2) elevates DDX3 expression to inhibit ...
#Adaptations #amino #acid #substitutions #biodiversity #RNA-mediated #supercoiled #DNA #viral #latency
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Grok: Ignoring facts /clinging to consensus (4) KohlGrok: Ignoring facts /clinging to consensus (3) “…high glucose promoted circANKRD36 expression, the proportion of CD11b+CD86+ cells, and mRNA...
#Adaptations #amino #acid #substitutions #biodiversity #pheromone-controlled #RNA-mediated #supercoiled #DNA #viral #latency
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Grok: Ignoring facts /clinging to consensus (4) KohlGrok: Ignoring facts /clinging to consensus (3) “…high glucose promoted circANKRD36 expression, the proportion of CD11b+CD86+ cells, and mRNA...
#Adaptations #amino #acid #substitutions #biodiversity #pheromone-controlled #RNA-mediated #supercoiled #DNA #viral #latency
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Grok: Ignoring facts /clinging to consensus (4) KohlGrok: Ignoring facts /clinging to consensus (3) “…high glucose promoted circANKRD36 expression, the proportion of CD11b+CD86+ cells, and mRNA...
#Adaptations #amino #acid #substitutions #biodiversity #pheromone-controlled #RNA-mediated #supercoiled #DNA #viral #latency
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Grok: Ignoring facts /clinging to consensus (4) KohlGrok: Ignoring facts /clinging to consensus (3) “…high glucose promoted circANKRD36 expression, the proportion of CD11b+CD86+ cells, and mRNA...
#Adaptations #amino #acid #substitutions #biodiversity #pheromone-controlled #RNA-mediated #supercoiled #DNA #viral #latency
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Biophysically constrained viruses (9) Elon Musk Please provide examples where @Grok needs to improve in replies. Showing how another AI does it better would be helpful. These examples should be of ...
#Adaptations #amino #acid #substitutions #biodiversity #natural #selection #RNA-mediated #supercoiled #DNA #viral
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Protein synthesis at the origin of life (8) We are begging Joe Rogan for a voice We represent millions of pain patients who have been ripped off their long-term opioid medications Many of these pat...
#Adaptations #amino #acid #substitutions #biodiversity #natural #selection #RNA-mediated #supercoiled #DNA #viral
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Tebas Responds to Ancelotti's Complaints on Player Rest and TV Costs
#Ancelotti #football #laliga #Substitutions #Tebas
https://blazetrends.com/tebas-responds-to-ancelottis-complaints-on-player-rest-and-tv-costs/?fsp_sid=703 -
''Compared to the Svalbard avian index case, #PB2 #segment of the walrus sequence contained only 2 aa #substitutions, including #E627K mutation, which is known to enhance #infectivity in #mammals. Interestingly, all avian HPAIV H5N5 from Norway, as well as the walrus sequence, have a set of 6 aa in PB2 that have been reported to favour infection of mammals [Citation11].''
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''Compared to the Svalbard avian index case, #PB2 #segment of the walrus sequence contained only 2 aa #substitutions, including #E627K mutation, which is known to enhance #infectivity in #mammals. Interestingly, all avian HPAIV H5N5 from Norway, as well as the walrus sequence, have a set of 6 aa in PB2 that have been reported to favour infection of mammals [Citation11].''
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''Compared to the Svalbard avian index case, #PB2 #segment of the walrus sequence contained only 2 aa #substitutions, including #E627K mutation, which is known to enhance #infectivity in #mammals. Interestingly, all avian HPAIV H5N5 from Norway, as well as the walrus sequence, have a set of 6 aa in PB2 that have been reported to favour infection of mammals [Citation11].''
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''Compared to the Svalbard avian index case, #PB2 #segment of the walrus sequence contained only 2 aa #substitutions, including #E627K mutation, which is known to enhance #infectivity in #mammals. Interestingly, all avian HPAIV H5N5 from Norway, as well as the walrus sequence, have a set of 6 aa in PB2 that have been reported to favour infection of mammals [Citation11].''
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''Compared to the Svalbard avian index case, #PB2 #segment of the walrus sequence contained only 2 aa #substitutions, including #E627K mutation, which is known to enhance #infectivity in #mammals. Interestingly, all avian HPAIV H5N5 from Norway, as well as the walrus sequence, have a set of 6 aa in PB2 that have been reported to favour infection of mammals [Citation11].''
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''all five isolates harbored HA #markers (226Q and 228G), suggesting more efficient #binding to avian receptors than to human #receptors, while all five strains had amino acid #substitutions that included 133A and 156A which might increase binding affinity to human-like receptors''
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#Detection of #influenza #H3N2 viruses with #polymerase acidic subunit #substitutions after & prior to #baloxavir marboxil #treatment during the 2022-23 influenza season in Japan, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224001657?via%3Dihub
2 viruses harboring PA/I38T (0.8%) prior to antiviral treatment were observed. 8 viruses with PA variants (14.8%) appeared after baloxavir administration. Duration of fever & symptoms between patients with & without PA #variants after baloxavir treatment & not differ.
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The #H4 #subtype of avian #influenza virus: a #review of its historical #evolution, global #distribution, adaptive #mutations and #receptor #binding properties, Poul Sci.: https://www.sciencedirect.com/science/article/pii/S0032579124004929?via%3Dihub
The Q226L/G228S #substitutions in the receptor-binding site have led to structural changes in globular head of H4 AIV, resulting in a configuration similar to that of #pandemic #H2N2 and #H3N2 human influenza viruses.
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#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1
Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.
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#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1
Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.
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#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1
Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.
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#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1
Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.
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#Virological characteristics of the #SarsCoV2 #KP3, #LB1 and #KP23 #variants, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.05.597664v1?rss=1
Our results suggest that S #substitutions convergently acquired in #JN1 #subvariants contribute to immune evasion, & increase their Re when compared to parental JN.1. LB.1 & KP.2.3 exhibited higher pseudovirus #infectivity & more immune resistance than KP.2. Data suggest that S:S31del is critical to exhibit +infectivity, +immune evasion, & potentially contributes to increased Re.
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The #impact of #PA/I38 #substitutions and PA #polymorphisms on the susceptibility of #zoonotic #influenza A viruses to #baloxavir, Arch Virol.: https://doi.org/10.1007/s00705-023-05958-5