#rnasplicing — Public Fediverse posts

Technical Assistant position – lncRNA localization regulation and function
Goethe University

See the full job description on jobRxiv: https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/

#cellbiology #noncodingRNAs #RNA #rnalocalization #RNAsplicing #ScienceJobs #hiring #research
https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/?fsp_sid=7039

Technical Assistant position – lncRNA localization regulation and function
Goethe University

See the full job description on jobRxiv: https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/

#cellbiology #noncodingRNAs #RNA #rnalocalization #RNAsplicing #ScienceJobs #hiring #research
https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/?fsp_sid=6703

Technical Assistant position – lncRNA localization regulation and function
Goethe University

See the full job description on jobRxiv: https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/

#cellbiology #noncodingRNAs #RNA #rnalocalization #RNAsplicing #ScienceJobs #hiring #research
https://jobrxiv.org/job/goethe-university-27778-technical-assistant-position-lncrna-localization-regulation-and-function/?fsp_sid=6444

This study shows that #RNAsplicing is widely dysregulated when #FMRP is lost; this involves multiple splicing factors, including MBNL1. In FMRP-depleted cells, Mbnl1 RNA is misspliced, mislocalizing #MBNL1, and in turn messing up further RNAs #PLOSBiology https://plos.io/3R6E9GN

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer

'Gene duplication and diversification allow hosts to mutate otherwise essential genes, whereas changes in transcriptional regulation can selectively activate genes should their constitutive expression be detrimental. To counter mutational tolerance, it has been suggested that viruses target essential genes as host cofactors, because the genes are less prone to variability'

#Virology #HostPathogen #RNASplicing

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001934

"Here, we utilized unbiased genetic screens to map drug/gene interactions for a variety of clinically approved therapies used in the treatment of AML. This effort highlighted a unique genetic relationship between response to venetoclax and the function of specific RNA splicing factors."

#AML #leukemia #venetoclax #BCL2 #Apoptosis #RNASplicing #AcuteMyeloidLeukemia

https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00588-8

Pre-mRNA splicing patterns cannot be accurately defined from total RNA data, unless degradation pathways are inactive. An example, using NMD inactivation (wondering to what extent nuclear degradation could be also involved ?):

https://pubmed.ncbi.nlm.nih.gov/35264448/

#RNAsplicing #nmd #ribosome