Hexokinase 2 (HK2) is known for its metabolic role in #glycolysis. This study shows that it also functions as an #RNAbindingProtein that regulates mRNA translation, particularly of SOX10, promoting #melanoma cell proliferation independently of glycolysis @PLOSBiology https://plos.io/3ViI1qL
#rnabindingprotein — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #rnabindingprotein, aggregated by home.social.
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This looks like a very interesting #preprint @biorxivpreprint from Christine Mayr lab:
"The FXR1 network acts as signaling scaffold for actomyosin remodeling"
#RNA #mRNA #RNABindingProtein #microscopy -
Microglia-mediated inflammation is involved in #IschemicStroke. This study reveals that the TF NR4A1 has a novel role in #microglia as an #RNAbindingProtein that destabilizes pro-inflammatory transcripts & alleviates ischemic #BrainInjury #PLOSBiology https://plos.io/3Q4w4n8
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This looks like a super-useful method!
"Oligonucleotide-directed proximity-interactome mapping (O-MAP): A unified method for discovering RNA-interacting proteins, transcripts and genomic loci in situ"