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#quantitativebiology — Public Fediverse posts

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  1. Version of free #textbook for #biology undergraduates "Quantitative Concepts for Biologists" with many corrections for typos/grammar:
    doi.org/10.5281/zenodo.21275274
    Ran the complete LaTeX source through an open weights LLM and used emacs/ediff to decide on each change.
    #quantitativebiology

  2. Cell migration is fundamental to many biological processes (cancer metastasis, cellular immunity, development, ...). Here we introduce a new computational method & free tool to evaluate high-throughput cell migration assays.
    #cancer #cellmigration #Bayes #quantitativebiology
    doi.org/10.1371/journal.pcbi.1

  3. If you are looking for an introductory textbook on #QuantitativeBiology for undergraduates: I have just uploaded a free book (with exercise material) that I have written over the last months. It is the first edition, so have mercy.

    doi.org/10.5281/zenodo.21275274

    #education #biology

  4. 🤒 Why do we actually get a #fever? One reason is that immune cells move faster at higher temperatures. A team led by Stefan Wieser at the Institute of Zoology has now uncovered the molecular mechanism behind this process, with the motor protein myosin II taking center stage.

    🆕 uibk.ac.at/en/newsroom/heat-ac

    📖 cell.com/developmental-cell/fu

    #biology #cellularBiology #quantitativeBiology #molecularBiology #cellBiology #cellularBiology #cells #singleCellBiology

  5. Branching out: Tomato genes point to new medicines

    The Takeaway CSHL’s Lippman and McCandlish labs have discovered how interactions between cryptic genetic mutations can increase or…
    #NewsBeep #News #Genetics #AU #Australia #DavidMcCandlish #Geneticsresearch #genomesequencing #PlantBiology #plantgenetics #QuantitativeBiology #Science #ZacharyLippman
    newsbeep.com/au/9661/

  6. Branching out: Tomato genes point to new medicines

    The Takeaway CSHL’s Lippman and McCandlish labs have discovered how interactions between cryptic genetic mutations can increase or…
    #NewsBeep #News #Genetics #CA #Canada #DavidMcCandlish #Geneticsresearch #genomesequencing #PlantBiology #plantgenetics #QuantitativeBiology #Science #ZacharyLippman
    newsbeep.com/ca/11385/

  7. 6. 7/8 🌐📚 Future prospects: there was so little biochemical data for our specific proteins, we had to rely on genome-wide data (PBMs). We could then estimate Kd for ANY sequence. That means, also for sequence variants.

    Our earlier Framework Model v2 (FMv2) and FM-Life models link the clock right up, through plant metabolism, growth, development and physiology, to seed-to-seed adaptation in real weather.

    Anyone who assembles these parts gets to predict how an Arabidopsis genome sequence variant will be adapted to climatic conditions. With a full causal chain. The mechanisms of evolutionary adaptation.👀 #GoForIt

    Sure it’s simplified and there’s much to validate but it’s there. DNA-binding Kd is just where we started, there’s more known biochemistry to add.

    #Evolution #LifeCycle #QuantitativeBiology #Arabidopsis

  8. It turns out it may be better to have (genetically) curly than straight hair (or no hair at all), 👩🏽‍🦱 especially under extreme heat and/or sun exposure - shows a recent study by
    @TinaLasisi
    et al. 🧬
    Tightly curled hair came off best in their experiment than other hair types (bald head, straight hair, moderately curled hair) regarding minimising sweating and overheating.

    #Anthropology #biologicalanthropology #QuantitativeBiology #ComputationalBiology

    nationalgeographic.com/premium

  9. Suggest a few good examples from mathematical and theoretical biology that can help to convince an uninitiated biologist that theory and mathematical models matter in Biology.

    I need a few examples for a general talk to a broader audience of "experimental biologists."

    #qBio #mathbio
    #QuantitativeBiology
    #theoreticalbiology
    #ScienceMastodon