#proteinproteininteractions — Public Fediverse posts

Computational Structural Biologist
Bindbridge

Bindbridge is advancing sustainable agriculture through AI-powered molecular glue discovery. We are looking for a Computational Structural Biologist!

See the full job description on jobRxiv: https://jobrxiv.org/job/bindbridge-27778-computational-structural-biologist/

#computationalstructuralbiology #cryoEM #molecularglues #proteinproteininteractions #Tar...
https://jobrxiv.org/job/bindbridge-27778-computational-structural-biologist/?fsp_sid=13222

🚀 What if we could precisely target the CAPON–nNOS axis — a pathway long considered undruggable?

🔗 Targeting CAPON to modulate the CAPON–NOS Axis: a computational approach. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.001

📚 CSBJ: https://www.csbj.org/

#DrugDiscovery #ComputationalBiology #AlzheimersResearch #Neuroscience #ProteinProteinInteractions #VirtualScreening #MolecularDynamics #AIinDrugDiscovery

💡 AI can predict protein structures — but can it predict how they behave?

🔗 AlphaFold3 prediction of protein-protein complex: Is it ready for thermodynamic analysis?. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.015

📚 CSBJ: https://www.csbj.org/

#AlphaFold3 #ProteinDesign #MolecularModeling #ComputationalBiology #StructuralBiology #Thermodynamics #ProteinProteinInteractions #Bioinformatics

Janus-Like Nature Leads to Unexpected Protein Oligomer Formation

Weak self-interactions lead to the formation of small but stable oligomers

https://www.chemistryviews.org/janus-like-nature-leads-to-unexpected-protein-oligomer-formation/

#proteinproteininteractions #immtac #chemistry #chemistryviews #chemviews

Huang Tan et al. describe their new Ti-TAN #plasmid toolbox for TurboID-based proximity labeling assays in N. benthamiana. Read the full paper here!
#PlantScience #OpenAccess #proteinproteininteractions #TurboID
https://onlinelibrary.wiley.com/doi/10.1111/jipb.13610

A new proteomic workflow establishing interdependencies between protein #phosphorylation & complex formation is applied to the signal integrator & Hippo pathway effector YAP1 ➡️ http://bit.ly/3mJ4W0t
Matthias Gstaiger @eth_en
#proteomics #interactome #ProteinProteinInteractions #CellSignaling

News &Views by
P Kastritis on the recent study from the Rappsilber lab identifying bacterial PPIs in their cellular context by combining whole-cell crosslinking, co-fractionation #massspectrometry & AI-based PPI structure prediction ➡️http://bit.ly/3FfcIVY
#proteomics #ProteinProteinInteractions #SystemsBiology #Alphafold

An integrative approach using crosslinking #massspectrometry (MS), co-fractionation MS & #Alphafold-Multimer discovers new protein complexes & their topologies in B.subtillis ➡️ http://bit.ly/3kpjocU
from Juri Rappsilber (TU Berlin), Jörg Stülke (Uni Goettingen)
#proteomics #SystemsBiology #ProteinProteinInteractions

ABOLISH: an optimised biotin-ligation method for discovering stable & transient #ProteinProteinInteractions in yeast ➡️ https://www.embopress.org/doi/full/10.15252/msb.202211084
from Maya Schuldiner's lab, Weizmann Institute
#SystemsBiology #Scerevisiae