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#proteinaggregation — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #proteinaggregation, aggregated by home.social.

  1. 🧬 Could a new form of amyloid aggregation change how we understand Alzheimer’s disease?

    🔗 Aggregation dynamics of a 150 kDa Aβ42 oligomer: Insights from cryo electron microscopy and multimodal analysis. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.csbj.2024.11

    📚 CSBJ: csbj.org/

    #CryoEM #ProteinAggregation #Biophysics #StructuralBiology #AlzheimersResearch #Neuroscience #DrugDiscovery #AmyloidBeta

  2. #ProteinAggregation is a hallmark of #neurodegeneration. This study shows that HAPLN2 aggregates in the aging brain, triggering #inflammation; microglial clearance regulates HAPLN2 buildup. This links protein accumulation to immune activation in healthy #aging @PLOSBiology plos.io/4fJy7YG

  3. Failure of #ProteinQC in #Celegans triggers a mechanism involving pathogen response factors & #lysosome-mediated degradation, promoting tissue-specific resilience to age-dependent #ProteinAggregation & #proteotoxicity @DellaDavid_Lab &co #PLOSBiology plos.io/44QeDdD