#pmx — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #pmx, aggregated by home.social.
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The estimand framework, formalized in ICH E9(R1) regulatory guidance, provides a structured approach to define scientific objectives with precision. We apply the estimand framework to dose–exposure–response analyses. ... strategy to improve exposure–response analyses for dose selection, particularly when the relevant evidence includes data from multiple studies.
#estimand #exposure-response #dose-response #causal #pharmacometrics #pmx
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The estimand framework, formalized in ICH E9(R1) regulatory guidance, provides a structured approach to define scientific objectives with precision. We apply the estimand framework to dose–exposure–response analyses. ... strategy to improve exposure–response analyses for dose selection, particularly when the relevant evidence includes data from multiple studies.
#estimand #exposure-response #dose-response #causal #pharmacometrics #pmx
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The estimand framework, formalized in ICH E9(R1) regulatory guidance, provides a structured approach to define scientific objectives with precision. We apply the estimand framework to dose–exposure–response analyses. ... strategy to improve exposure–response analyses for dose selection, particularly when the relevant evidence includes data from multiple studies.
#estimand #exposure-response #dose-response #causal #pharmacometrics #pmx
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The estimand framework, formalized in ICH E9(R1) regulatory guidance, provides a structured approach to define scientific objectives with precision. We apply the estimand framework to dose–exposure–response analyses. ... strategy to improve exposure–response analyses for dose selection, particularly when the relevant evidence includes data from multiple studies.
#estimand #exposure-response #dose-response #causal #pharmacometrics #pmx
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The estimand framework, formalized in ICH E9(R1) regulatory guidance, provides a structured approach to define scientific objectives with precision. We apply the estimand framework to dose–exposure–response analyses. ... strategy to improve exposure–response analyses for dose selection, particularly when the relevant evidence includes data from multiple studies.
#estimand #exposure-response #dose-response #causal #pharmacometrics #pmx
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Huh
So I went through all that trouble finding out how to get a #fbx (without using #Blender or #CATS plugin - despite how good it may be)
to realize:
#Sketchfab has:
* limited uploads
* displays #static models (not sure if I could embed an #animation
* sigh
Srsly ?
My own #webrender split off can do more than that
https://alceawis.de/mmdlatest.html
What a waste of time :blobcathuggies_sad:
BLEH !
#DisappontedAo
The processin on #sketchfab takes forever too.
Are they struggling with my #pmx / #mmd ik bone names ? :AC_Isabelle_Laughing: -
@Dr_Muesli
It's funny you say "see"
#Seeing is a thing that is quite hard with a #blindfold
https://www.youtube.com/watch?v=xzHFGwEPyow&feature=youtu.be
the blue does are #bones
And the first one is the #vrm #export
I could have #disabled them a bit to keep the hair
But the more she #resembles the original, the more likely it is #copyright goons will come my way.
The #pmx renderer renders her fine -
@justinwilkins As for general #Pmx applications, were you aware of Vijay Ivaturi's https://pumas.ai/ ?
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@dcnorris This sounds juicy. Care to expand? #JuliaLang has been on the radar a while now but I have yet to see a compelling #Pmx application
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For those interested, there are lots of journals that publish in #PMx, including
- Journal of Pharmacokinetics and Pharmacodynamics (JPKPD)
- Clinical Pharmacology and Therapeutics: Pharmacometrics and Systems Pharmacology (CPT:PSP)
- The AAPS Journal (AAPS J)The International Society of Pharmacometrics (#ISoP) is the professional scientific association for #PMx. I was a member of its Board of Directors, and it's one of the most fun and rewarding things I've done.
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Modeling tools in our area are largely closed-source and massively expensive, and are a gigantic entry barrier for new people, especially in low and middle-income countries (and borderline unaffordable even for CROs like mine). #nlmixr2 is intended to be a solution to this problem. I also maintain the #pmxTools package, which provides a handy set of general #PMx functions.
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I promised you #Beer! It's actually a pretty good example. PK describes what happens to the alcohol (ethanol) you consume between the glass and the bathroom, and PD describes what it does while it's circulating in your blood (quite a few things, including making you tipsy). Ethanol is a pretty interesting case, because it's eye-wateringly complex. The #DrinkMe simulation on Nick Holford's website is a fun interactive example of how it fits together! #PMx
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Wikipedia defines #Pharmacometrics (#PMx) as a field of study of the methodology and application of #models for disease and pharmacological measurement. It applies mathematical models of #biology, #pharmacology, #disease, and #physiology to describe and quantify interactions between #xenobiotics (drugs) and patients (human and non-human), including both beneficial and adverse effects.