#pituitary — Public Fediverse posts

Got it together to write an update! Got sick, took a few months to recover, so it's been a while. Coming out of a quasi-stupor, to be completely honest. A long, dark tunnel. Lately, it's like something has snapped back into place inside me. It's like my brain and body are in the process of going back online - how far this recovery goes, nobody knows. For now, I'll leave you with this "quarterly report." 🥰

https://mailchi.mp/99065d8be764/chapterthree

#DisabilityMatters #Pituitary #Healthcare #Medicine

Our new preprint is now out!

Dynamic transcriptional heterogeneity in pituitary corticotrophs

https://www.biorxiv.org/content/10.1101/2025.04.04.645979v1

We analysed publicly available single-cell RNA sequencing data of pituitary gland tissue and looked at corticotrophs, cells that are central to mediate stress responses.

We identified several transcriptional states in these cells that are related to how they respond to stress. Cells are able to transition between these states and this might be helpful for them to respond to stress coming at unpredictable times.

We also highlight issues related to using scRNAseq to look at functional subpopulations of cells.

#scrnaseq #stress #physiology #cellbiology #bioinformatics #corticotrophs #pituitary

#CarmineClemente - How Do #Human #Brains #Think and #Feel?

https://www.youtube.com/watch?v=GecPtAXpcJY

#Philosophy #PhilosophyOfScience #Science #PhilosophyOfMedicine #Medicine #Biology #PhilosophyOfBiology #Brain #Thinking #Feeling #Consciousness #PhilosophyOfConsciousness #Awareness #Learning #Pituitary #Hypothalamus #Hormone #Hormones #Appetite #CloserToTruth #RobertKuhn

The #pituitary responds to and modulates immune stress via the hypothalamus-pituitary-adrenal axis. @TristanLi_Lab explores a #PLOSBiology study revealing 2-way communication between hormone-producing & immune cells during #inflammation Paper: https://plos.io/41tW2Ec Primer: https://plos.io/3GOUk6G

The #pituitary and #stress: #scRNAseq reveals that systemic inflammatory stress alters gene expression of all #PituitaryHormone-producing cells, increasing expression of many secretory factors & fostering interactions with immune cells #PLOSBiology https://plos.io/41tW2Ec

Very happy to share our newly published #article "Sex differences in pituitary corticotroph excitability".

It is well known that sex differences exist in stress-related disorders, with women having twice the lifetime rate of depression compared to men and most anxiety disorders.

Corticotroph cells in the pituitary gland are a key player in the generation of hormonal stress responses. However, their contribution to sexually differential responses of the stress axis (which might underlie differences in stress-related disorders) is very poorly understood.

We found sex differences in the electrical activity of these cells, which could be related to differences in their gene expression pattern.

These findings shed light on the cellular mechanisms underlying sex differences in stress responses, contributing to a better understanding of stress-related disorders and potential avenues for diagnosis and treatment.

#stress #pituitary #research #electrophysiology #physiology #corticotrophs #hpa #anxiety

https://www.frontiersin.org/articles/10.3389/fphys.2023.1205162/full

I thought I would share this image, which I took a while ago, but that I really like! This is a #pituitary gland where cells expressing a protein called proopiomelanocortin (POMC for short) have been coloured in green. You can see two groups of cells; a very packed band in the middle and some sparse cells on the sides. The first are called melanotrophs, and they are important in determining skin and fur colour. The sparse cells on the sides are called corticotrophs (and that's what I am studying at the moment!) and they are important for the response to #stress . They secrete an #hormone called ACTH which stimulates the production of the stress hormone cortisol from the adrenal gland. At the moment we are trying to understand what happens to this cells after the body is exposed to stress for a prolonged amount of time. #scicomm #biology #science #physiology #microscopy

Hello everyone! Here's my #introduction! I am a senior lecturer at the University of Edinburgh, mostly teaching biomedical #ImageAnalysis and #DataScience ( #machinelearning #statistics and all that jazz) using #rstats and #python. My research interests revolve around #neuroendocrinology that is, understanding how your brain controls the production of hormones in your body. I am particularly interested in the role of #heterogeneity of cells in the #pituitary gland and how that contributes to generating the right pattern of hormones at the right time!