#peramivir — Public Fediverse posts

#USA, #Flu #Antiviral Drugs #Resistance: Two A #H1N1pdm09 viruses had NA-H275Y amino acid substitution conferring highly reduced #inhibition by #oseltamivir and #peramivir. One A #H1N1pdm09 virus had NA-I223V and NA-S247N amino acid substitutions and showed reduced inhibition by #oseltamivir. FluView: https://www.cdc.gov/fluview/surveillance/2025-week-05.html

Whole-Genome #Analysis of #Influenza #H1N1pdm09 Viruses Isolated from ILI #Outpatients in #Myanmar & CA #Oseltamivir-Resistant Strains Present from 2015 to 2019 https://pubmed.ncbi.nlm.nih.gov/39205274/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=10ykRO9og5pGdo51l9DEPEpOJ3DVFIn__QK2QPM3dci1C1dEYq&fc=None&ff=20240831103754&v=2.18.0.post9+e462414

3 viruses possessed the #H275Y substitution in #neuraminidase protein, appearing to be community-acquired without prior administration of neuraminidase inhibitors. These viruses exhibited highly reduced susceptibility to #oseltamivir and #peramivir.

[Articles] #Antivirals for #treatment of severe #influenza: a systematic #review and network meta-analysis of randomised controlled trials https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01307-2/fulltext?rss=yes

In hospitalised patients with severe flu, #oseltamivir & #peramivir might reduce duration of hospitalisation compared with standard care or placebo, although certainty of evidence is low. Effects of all antivirals on mortality & other important patient outcomes are very uncertain due to scarce data from #RCTs.

Whole- #Genome #Analysis of #Influenza #H1N1pdm09 Viruses Isolated from #ILI #Outpatients in #Myanmar & Community-Acquired #Oseltamivir - #Resistant Strains Present from 2015 to 2019 https://www.mdpi.com/1999-4915/16/8/1300

1 virus intra-subtype reassortment, collected in the '15 season. 3 viruses possessed #H275Y substitution in NA protein, appearing to be CA without prior administration of neuraminidase #inhibitors. These viruses exhibited highly reduced susceptibility to #oseltamivir & #peramivir.

#h5n1 #birdflu #avianflu #hpai #h5n2 #influence #grippe #flu #press #news

#antivirale #Medikamente #Virostatika geg #Influenza:

#Oseltamivirphosphat (als Generikum od. unter Handelsnamen #Tamiflu)
#Zanamivir ( #Relenza )
#Peramivir ( #Rapivab )
#Baloxavir ( #Xofluza )
Bei bestätigter od. Verdacht auf #Vogelgrippe wird schnellstmögl. Behandlung empfohlen

Tiermodelle & #Beobachtungsstudien deuten auf Nutzen von Virostatika bei mit Vogelgrippe infizierten #Menschen hin

https://www.medscape.com/viewarticle/new-human-cases-avian-flu-anticipated-2024a1000bfg?form=fpf

#Antivirals for #treatment of severe #influenza: a systematic #review and network meta-analysis of randomized controlled trials, MedRxIV, https://www.medrxiv.org/content/10.1101/2024.05.28.24307938v1

In hospitalized patients with severe influenza, #oseltamivir and #peramivir may reduce duration of hospitalization compared with standard care or placebo. The effects of all antivirals on #mortality and other important patient outcomes are very uncertain.

''Phenotypic testing of 22 clade 2.3.2.1a and 2.3.4.4b viruses revealed broad susceptibility to NAIs and #baloxavir concluding that most contemporary HPAI A(#H5N1) viruses retain susceptibility to #antiviral drugs. Novel NA-K432E and NA-T438I #substitutions (N2 numbering) were identified at **elevated frequencies** (104/2698, 3.85%) and caused reduced #zanamivir and #peramivir inhibition.''