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am730 @[email protected] · 2026-06-10 · 02:04 UTC

外泌體 vs PDRN 有何分別？拆解2大熱門抗老修復成分
https://www.am730.com.hk/生活/1034301/外泌體-vs-pdrn-有何分別-拆解2大熱門抗老修復成分

#外泌體 #pdrn #抗老 #修復 #分別 #拆解

Rhyothemis @[email protected] · 2026-04-26 · 20:29 UTC

I started reading up on PDRN after seeing skin care products touting it as an ingredient. How it is produced is gross - apparently there are vegan versions and I want look up the literature on them to see if they are comparable in activity.

I don't know if topical application works, but I may try a product to see for myself. I'm particularly interested in PDRN eye drops for dry, irritated eyes (ReAn). The drops are sold OTC in Korea; I don't know if I can get them here or have them shipped.

The MOA is interesting. I would have thought that foreign DNA fragments would act as a DAMP and increase inflammation, not reduce it. I could see DAMPs spurring regeneration, though.

#PDRN #RegenerativeMedicine #SkinCare #DryEye

#pdrn #regenerativemedicine #skincare #dryeye

Rhyothemis @[email protected] · 2026-04-25 · 19:59 UTC

Polydeoxyribonucleotide (PDRN) in Dentistry: Narrative Review for Mechanisms and Emerging Clinical Applications [2026]
https://pmc.ncbi.nlm.nih.gov/articles/PMC12855666

"Polydeoxyribonucleotide (PDRN) is a DNA-derived compound primarily extracted from the sperm of Oncorhynchus mykiss (Salmon Trout) or Oncorhynchus keta (Chum Salmon), consisting of polymeric chains of deoxyribonucleotides with molecular weights ranging from 50 to 1500 kDa [1]. From a single salmon or trout, approximately 5–10 mL of milt (sperm) can be obtained to yield these low-molecular-weight DNA fragments, including PDRN and other polynucleotides.2 In practical terms, PDRN is essentially a mixture of DNA fragments."

"PDRN’s therapeutic effects in tissue regeneration are primarily achieved through two mechanisms: (1) the salvage pathway, and (2) activation of adenosine A2A receptors."

#aging #health #dentistry #PDRN #RegenerativeMedicine