#pdac — Public Fediverse posts

“Any attempt to sideline or bypass our member First Nations will not only jeopardize project success but also undermine the legitimacy of the development process itself.”

#Indigenous #FirstNations #PDAC #mining #ONpoli #cdnpoli #investment

https://www.windspeaker.com/news/opinion/ensuring-certainty-critical-minerals-development-requires-genuine-partnership

What a break-through!

Spanish scientists completely cure pancreatic cancer (PDAC) in mice.

The group focused on KRAS, a gene mutated in 90% of people with pancreatic cancer. The team employed a triple therapy, which combined an experimental KRAS inhibitor (daraxonrasib) with an approved drug for certain lung adenocarcinomas (afatinib) and a protein degrader (SD36).

#PDAC #PancreaticCancer #Science #Medicine #Oncology #CancerTreatment

https://www.cnio.es/en/news/the-group-led-by-barbacid-at-cnio-completely-eliminates-pancreatic-tumours-in-mice-with-no-resistance-developing/

After three intensive days of scientific excellence, our course has come to an end. It has been an honor to have such committed and passionate students participating in pancreatic ductal adenocarcinoma (PDAC) research. Thank you to all our students for making this course a resounding success!

See you at the next edition!
#PancreaticCancer #Oncology #MedicalResearch #PDAC #SummerCourse

@Impossible_PhD I remember reading about Pfizer/BioNTech clinical trials for mRNA vaxx PDAC treatment in 2023, shortly after my mom was diagnosed.
This is immensely important and a huge breakthrough.
Extraordinary work by both BioNTech and MSKCC researchers.

https://www.mskcc.org/clinical-updates/custom-mrna-vaccines-pancreatic

#PDAC #mRNA

We’re excited to share our latest research: “ELOVL6 as a Therapeutic Target: Disrupting c-MYC-Driven Lipid Metabolism to Enhance Chemotherapy in Pancreatic Cancer.”

https://www.biorxiv.org/content/10.1101/2024.11.11.622928v1

Targeting metabolic dependencies like ELOVL6 in c-MYC-driven cancers could open new avenues in PDAC treatment, offering hope for better patient outcomes. Follow us for updates as we continue exploring the therapeutic potential of lipid metabolism in cancer

#PDAC

Today, I gave a lesson on tyrosine kinase receptors and serine/threonine kinase receptors, focusing on their signaling pathways and mutations in cancer. Two notable examples are EGFR and TGFBR. #PDAC

Probiotics functionalized with a gallium-polyphenol network modulate the intratumor microbiota and promote anti-tumor immune responses in pancreatic cancer #pancreaticcancer #PDAC https://www.nature.com/articles/s41467-024-51534-z

#Pancreatic ductal #adenocarcinoma (PDAC) is a deadly #cancer. @RoLiefke &co show that chromatin regulator SAMD1 represses EMT-related genes, inhibiting cellular migration, and is downregulated during #PDAC progression by #E3ligase FBXO11 #PLOSBiology https://plos.io/4crkx94

LIM domain only 7: a novel driver of immune evasion through regulatory T cell differentiation and chemotaxis in pancreatic ductal adenocarcinoma #pancreaticcancer #PDAC https://www.nature.com/articles/s41418-024-01358-7

UPF1 deficiency enhances mitochondrial ROS which promotes an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma #pancreaticcancer #PDAC https://www.pnas.org/doi/abs/10.1073/pnas.2401996121?af=R

Hallmarks of pancreatic cancer: spotlight on TAM receptors #pancreaticcancer #PDAC https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(24)00314-1/fulltext?rss=yes

Enhanced cytokine signaling and ferroptosis defense interplay initiates obesity-associated pancreatic ductal adenocarcinoma #PDAC https://www.sciencedirect.com/science/article/pii/S0304383524005573?dgcid=rss_sd_all

Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2 #PDAC https://gut.bmj.com/content/73/9/1509

Liposomal irinotecan, oxaliplatin, and S-1 as first-line therapy for patients with locally advanced or metastatic pancreatic adenocarcinoma (NASOX): A multicenter phase I/IIa study #PDAC https://www.sciencedirect.com/science/article/abs/pii/S0959804924008505

Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance #PDAC https://www.sciencedirect.com/science/article/pii/S2211124724007381?dgcid=rss_sd_all

Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer | Science #PDAC https://www.science.org/doi/10.1126/science.adh4567

Enhancing #PDAC Therapy: Decitabine-Olaparib Synergy Targets KRAS-Dependent Tumors http://biorxiv.org/cgi/content/short/2024.06.23.599676v1?rss=1

The E3 ubiquitin ligase TRIP12 is required for pancreatic acinar cell plasticity and pancreatic carcinogenesis #PDAC https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6298?af=R

Engineered extracellular vesicles for targeted reprogramming of cancer-associated fibroblasts to potentiate therapy of pancreatic cancer #PDAC https://www.nature.com/articles/s41392-024-01872-7

N6-methyladenosine modified TGFB2 triggers lipid metabolism reprogramming to confer pancreatic ductal adenocarcinoma gemcitabine resistance #PDAC https://www.nature.com/articles/s41388-024-03092-3

A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction #PDAC https://onlinelibrary.wiley.com/doi/10.1002/advs.202307695?af=R

In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer #PDAC https://www.nature.com/articles/s41467-024-49450-3

Multilevel Regulation of NF‐κB Signaling by NSD2 Suppresses Kras‐Driven Pancreatic Tumorigenesis #PDAC https://onlinelibrary.wiley.com/doi/10.1002/advs.202309387?af=R

CRISPR-Cas9 for selective targeting of somatic mutations in pancreatic cancers #PDAC https://academic.oup.com/narcancer/article/doi/10.1093/narcan/zcae028/7695997?rss=1

Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and in vivo metastasis #PDAC http://biorxiv.org/cgi/content/short/2024.06.14.599032v1?rss=1

Three-dimensional environment sensitizes pancreatic cancer cells to the anti-proliferative effect of budesonide by reprogramming energy metabolism #PDAC https://jeccr.biomedcentral.com/articles/10.1186/s13046-024-03072-1

The TRIM28/miR133a/CD47 axis acts as a potential therapeutic target in pancreatic necrosis by impairing efferocytosis #PDAC https://www.sciencedirect.com/science/article/abs/pii/S1525001624003873

Pancreatic cancer cells exchange ribosomes through tunneling nanotubes #PDAC http://biorxiv.org/cgi/content/short/2024.06.06.597772v1?rss=1

Identification of Ppy‐lineage cells as a novel origin of pancreatic ductal adenocarcinoma #PDAC https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.6295?af=R

Natural killer cells associate with epithelial cells in the pancreatic ductal adenocarcinoma tumor microenvironment #PDAC http://biorxiv.org/cgi/content/short/2024.05.23.593868v1?rss=1