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#pbpk — Public Fediverse posts

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  1. ZeroPM @[email protected] ·

    🧩#ZeroPMPieces #12:
    How can you avoid #animaltesting when assessing the #toxicity of #PFAS and #PMT substances?

    Watch Sylvia Escher from
    @Fraunhofer ITEM
    explain #PBPK modelling and new approach methodologies (#NAMs)

    youtu.be/Zim_Y8Psrfc

    🧠🫀 🫁

    #pbpk #nams #zeropmpieces #animaltesting #toxicity #pfas
  2. Justin Wilkins @justinwilkins ·

    Physiologically-based PK (#PBPK) models, for example, find the middle ground between PK and , having a more mechanistic bent by taking into account anatomical, physiological, physical, and chemical descriptions of the phenomena involved in complex absorption, distribution, metabolic and elimination (#ADME) processes, while remaining fundamentally driven by observed data.

    #pbpk #qsp #adme
  3. Justin Wilkins @[email protected] ·

    Physiologically-based PK (#PBPK) models, for example, find the middle ground between PK and #QSP, having a more mechanistic bent by taking into account anatomical, physiological, physical, and chemical descriptions of the phenomena involved in complex absorption, distribution, metabolic and elimination (#ADME) processes, while remaining fundamentally driven by observed data.

    #pbpk #qsp #adme