#osteocalcin — Public Fediverse posts

today I watched:

Karsenty: Osteocalcin and the Regulation of Muscle Mass

https://youtu.be/3bDwBRM2GKE?si=_NIbnkUi5l-8XFeC

older video, uploaded 19 Sep 2012

- bone is an endocrine tissue
- effects on aging
- undercaboxylated osteocalcin regulates insulin secretion, insulin sensitivity, testosterone secretion
- undercarboxylated osteocalcin promotes myoblast proliferation & muscle regeneration
- osteocalcin KO mice have decreased muscle oxidative capacity [10:40]
- study conducted on female mice to minimize effects of testosterone on muscle
- Esp inhibits osteocalcin by carboxylating it
- 21:31 summary slide
- credit to postdoc researcher Kathrin Laue
- presented by Gerard Karnsenty

#2dayIWatched #aging #BoneHealth #MuscleMass
#osteocalcin #biology #physiology