#opioid — Public Fediverse posts

In #Deutschland gebe es keine Hinweise auf eine so genannte #Opioid-Krise wie in den #USA. Der Anbieter #Grünenthal bewirbt #Tapentadol als wirksamer und sicherer als andere #Opioide – dafür fehlen aber überzeugende Daten 💊 (€)
https://gutepillen-schlechtepillen.de/opioid-krise-in-deutschland/

Passing this on because it is the best summary of the issues surrounding #Kratom I've seen to date...

"Legal Morphine’— The Rise of Kratom and 7-OH in the US"

https://www.medscape.com/viewarticle/legal-morphine-rise-kratom-and-7-oh-us-2025a1000cco

Key warning is 👉 avoid purified "7-OH" products. 👈

You CAN get too much of a good thing!

"The most well-studied compounds in kratom are #mitragynine and 7-OH... At low doses, mitragynine’s mixed receptor profile (adrenergic, serotonergic, dopaminergic) yields mild stimulant and mood-boosting effects."

"By contrast, concentrated 7-OH preparations are 30-40 times more potent at opioid receptors and produce rapid-onset analgesia, euphoria, respiratory depression, and classic #Opioid -type #withdrawal. As previously reported by Medscape Medical News, research has shown that 7-OH (formerly known as (7-HMG) has high abuse potential and may also increase the intake of other #opiates."

#OH7 #HMG7 #Addiction

Researchers use stem cells to generate human neurons resembling those in the brain that control breathing during opioid reactions, for eventual chip devices to test overdose therapies.

https://sciencebusiness.technewslit.com/?p=45185

#News #Press #Science #Business #Opioid #Overdose #Preclinical #Toxicity #Neurons #Breathing #Naloxone #Fentanyl #Codeine #Brain #Methadone #StemCells #Biotechnology #Engineering #Chemistry