#olaparib — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #olaparib, aggregated by home.social.
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A Common Blood Pressure Drug Makes Cancer Therapy Significantly More Powerful
https://1ban.news/telmisartan-boosts-olaparib-parp-inhibitor/
#1ban #telmisartan #boosts #olaparib #parp #science -
A Common Blood Pressure Drug Makes Cancer Therapy Significantly More Powerful
https://1ban.news/telmisartan-boosts-olaparib-parp-inhibitor/
#1ban #telmisartan #boosts #olaparib #parp #science -
"In conclusion, the newly identified PARP1-CTF18-Polϵ #exonuclease axis and HDR act independently to prevent fork collapse at single-ended double-strand breaks. #Olaparib inhibits this axis, explaining the pronounced #cytotoxic effects of olaparib on HDR-deficient cells."
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad999/7369941
#polymerase #DNA #replication #mutations #cancer #oncology #cellBiology #genetics
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"In conclusion, the newly identified PARP1-CTF18-Polϵ #exonuclease axis and HDR act independently to prevent fork collapse at single-ended double-strand breaks. #Olaparib inhibits this axis, explaining the pronounced #cytotoxic effects of olaparib on HDR-deficient cells."
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad999/7369941
#polymerase #DNA #replication #mutations #cancer #oncology #cellBiology #genetics
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Dr Eileen O’Reilly at #MSK ordered germline & somatic testing soon after Jay’s diagnosis with #PancreaticCancer, years before it was an #ASCO guideline. He was found to have a gBRCA1 mutation - targetable by #PARP inhibitor #olaparib - allowing a welcome chemo break. So grateful for the eight years we had post-diagnosis.
#PancreasCancer
#BRCA