#nucleocapsid — Public Fediverse posts

#SARSCoV2 has evolved to optimize its replication fitness in the human host. This study shows that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @PLOSBiology https://plos.io/3PIZMjr

#SARSCoV2 has evolved to optimize its replication fitness in the human host. This study shows that a #nucleocapsid gene mutation enhances production of a truncated protein that boosts viral fitness by suppressing #antiviral responses @PLOSBiology https://plos.io/3PIZMjr

Non-spike protein mutations in #SARSCoV2, likely to impact viral properties, are understudied. This study shows that a #nucleocapsid protein mutation in Delta variant enhances viral growth in vitro & in vivo by increasing viral genome #encapsidation @PLOSBiology https://plos.io/4iBYsaI

Non-spike protein mutations in #SARSCoV2, likely to impact viral properties, are understudied. This study shows that a #nucleocapsid protein mutation in Delta variant enhances viral growth in vitro & in vivo by increasing viral genome #encapsidation @PLOSBiology https://plos.io/4iBYsaI

AlphaFold2 Reveals Structural #Patterns of Seasonal #Haplotype #Diversification in #SARS-CoV-2 #Nucleocapsid Protein #Variants https://www.mdpi.com/1999-4915/16/9/1358

Our strategy of mapping the dynamic evolutionary landscape of genetically linked mutations to the N-protein structure demonstrates the utility of ab initio modeling and deep learning tools for therapeutic intervention.

AlphaFold2 Reveals Structural #Patterns of Seasonal #Haplotype #Diversification in #SARS-CoV-2 #Nucleocapsid Protein #Variants https://www.mdpi.com/1999-4915/16/9/1358

Our strategy of mapping the dynamic evolutionary landscape of genetically linked mutations to the N-protein structure demonstrates the utility of ab initio modeling and deep learning tools for therapeutic intervention.

#SARS-CoV-2 #papain-like #protease inhibits ISGylation of the viral #nucleocapsid protein to evade host anti-viral #immunity, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00855-24?af=R

The present study may contribute to gaining new insight into the roles of ISGylation-mediated anti-viral function in SARS-CoV-2 infection and may lead to the development of more potent and selective inhibitors targeted to SARS-CoV-2 nucleocapsid protein.

#SARS-CoV-2 #papain-like #protease inhibits ISGylation of the viral #nucleocapsid protein to evade host anti-viral #immunity, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00855-24?af=R

The present study may contribute to gaining new insight into the roles of ISGylation-mediated anti-viral function in SARS-CoV-2 infection and may lead to the development of more potent and selective inhibitors targeted to SARS-CoV-2 nucleocapsid protein.

#Detection of #Nucleocapsid #Antibodies Associated with Primary #SARS-CoV-2 #Infection in Unvaccinated and Vaccinated #Blood #Donors, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/8/24-0659_article

Nucleocapsid antibody assays can be used to estimate SARS-CoV-2 infection #prevalence in regions implementing #spike-based COVID-19 #vaccines. We also found good durability of nucleocapsid antibody detection for up to >1 year after infection.

#Detection of #Nucleocapsid #Antibodies Associated with Primary #SARS-CoV-2 #Infection in Unvaccinated and Vaccinated #Blood #Donors, Emerg Infect Dis.: https://wwwnc.cdc.gov/eid/article/30/8/24-0659_article

Nucleocapsid antibody assays can be used to estimate SARS-CoV-2 infection #prevalence in regions implementing #spike-based COVID-19 #vaccines. We also found good durability of nucleocapsid antibody detection for up to >1 year after infection.