#neutrophil — Public Fediverse posts

We did see 'health'-associated taxa increase in abundance post-therapy. There seemed to be a persistent difference in diversity between control group and PID group. We also observed interesting correlations with blood absolute #neutrophil counts and certain oral bacteria. This is certainly worth exploring further as these bacteria are part of the 'hedgehog' consortia in the dental plaque - dynamics are relevant for oral health in general. /end

During chronic #inflammatory diseases, how are neutrophils recruited to inflamed #skin? @PierreCoulombe8 @parentclab &co show that repeated acute stress to the skin amplifies a #neutrophil infiltration response involving keratin 17 & PKCα #PLOSBiology https://plos.io/3WVA62O

If you’re into #immunometabolism this one’s for you! My fellow Yoder Lab member, Emma Hepworth, will be talking about her work assessing how #PFHxA and #GenX affect #neutrophil metabolism. Find her tomorrow/Tuesday at poster 1.05.P-Tu-006!

#SETACLouisville 2/3

Single #cell spatial #analysis reveals #inflammatory foci of immature #neutrophil and #CD8 T cells in #COVID19 #lungs https://www.nature.com/articles/s41467-023-42421-0

To migrate efficiently, neutrophils must polarize their cytoskeletal regulators along a single axis of motion. @JasonPTown & @OWeinerLab use spatially-defined #optogenetic control of a leading edge organizer to explore how #neutrophil-like cells balance “decisiveness” (needed to polarize in one direction) with flexibility (to respond to new cues) #PLOSBiology https://plos.io/3ZAldnx

"As expected, early on-target recognition of melanoma antigens by tumor-specific CD4+ T cells was required. Surprisingly, complete tumor eradication was dependent on neutrophils and partly dependent on inducible nitric oxide synthase."

#Immunology #Immunotherapy #checkpointinhibitors #Neutrophil

https://www.cell.com/cell/pdf/S0092-8674(23)00225-8.pdf

Nice little study this, using SNPs in CCL19 & CCL21 linked with higher levels of these chemokines associated with greater #COVID19 infection and mortality.

Wonder if there's a mechanism. Greater #Neutrophil chemotaxis 👉 tissue pathology?

#IDMastodon #MedMastodon #immunopathology #immunology

CCL19 (rs3136658) and CCL21 (rs2812377) variants are associated with susceptibility and related mortality of SARS-CoV-2 infection: a population-based correlation analysis

https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad032/7022103

"Conditional absence of C3aR1/C5aR1 on neutrophils lowered serum BAFF levels, led to fewer Peyer’s patch germinal center B cells, reduced germinal center B cells IgA class-switching, and lowered fecal IgA levels. Together, the results indicate that sequential activation of complement on neutrophils crucially supports humoral TI and mucosal IgA responses through upregulating neutrophil production of BAFF."

#Immunology #TIndependentResponse #Neutrophil #BAFF

Hackaday Links: December 18, 2022 - By now everyone has probably seen the devastation wrought by the structural failur... - https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/ #structuralcollapse #electronicscourse #hackadaycolumns #manhattanstyle #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #slider #berlin #usnavy #neets #ugly #drm

Hackaday Links: December 18, 2022 - By now everyone has probably seen the devastation wrought by the structural failur... - https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/ #structuralcollapse #electronicscourse #hackadaycolumns #manhattanstyle #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #slider #berlin #usnavy #neets #ugly #drm

Hackaday Links: December 18, 2022 - By now everyone has probably seen the devastation wrought by the structural failur... - https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/ #structuralcollapse #electronicscourse #hackadaycolumns #manhattanstyle #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #slider #berlin #usnavy #neets #ugly #drm

Hackaday Links: December 18, 2022 - By now everyone has probably seen the devastation wrought by the structural failur... - https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/ #structuralcollapse #electronicscourse #hackadaycolumns #manhattanstyle #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #slider #berlin #usnavy #neets #ugly #drm

Hackaday Links: December 18, 2022 - By now everyone has probably seen the devastation wrought by the structural failur... - https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/ #structuralcollapse #electronicscourse #hackadaycolumns #manhattanstyle #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #slider #berlin #usnavy #neets #ugly #drm

Hackaday Links: December 18, 2022

https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/

#structuralcollapse #electronicscourse #HackadayColumns #ManhattanStyle #Hackadaylinks #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #Slider #berlin #USNavy #neets #ugly #drm

Hackaday Links: December 18, 2022

https://hackaday.com/2022/12/18/hackaday-links-december-18-2022/

#structuralcollapse #electronicscourse #HackadayColumns #ManhattanStyle #Hackadaylinks #hackadaylinks #immunesystem #abandonware #neutrophil #neuralink #aquarium #bricking #biology #Slider #berlin #USNavy #neets #ugly #drm

Another potential new role for eosinophils.

Antibacterial activity and associated with colitis.

They're increasingly taking on the role of simply a neutrophil subset!
#immunology #ScienceMastodon #neutrophil #eosinophil

https://www.nature.com/articles/s41586-022-05628-7?error=cookies_not_supported&code=272b7fea-57d3-447e-bb33-776166afd884&utm_medium=Social&utm_campaign=nature&utm_source=Twitt

Tomorrow young MSc students will watch this iconic movie of a #Leukocyte (#neutrophil) chasing a #Bacteria.

This version is taken from 16 mm video made by David Elliot Rogers @VanderbiltU in the 1950s.

(as @Mag2Art says "the Citizen Kane of #Microscopy)

#CellMigration #SciComm

"Activity tracing by plasma proteomic profiling uncovered an association between low NET clearance and increased COVID-19 pathology and mortality. Low NET clearance activity with comparable proteome associations was prevalent in healthy donors with low-grade inflammation, implicating defective chromatin clearance in the development of cardiovascular disease and linking COVID-19 susceptibility to pre-existing conditions"

#Immunity #Immunology
#Neutrophil #COVID19 #Pathology

https://www.cell.com/immunity/fulltext/S1074-7613(22)00597-0