#neuraminidases — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #neuraminidases, aggregated by home.social.
-
Increase of #Synergistic Secondary #Antiviral #Mutations in the #Evolution of #H1N1pdm09 #Influenza Virus #Neuraminidases, Vaccines: https://www.mdpi.com/1999-4915/16/7/1109
The data indicate a slight increase in viral NA bearing two additional potentially synergistic substitutions, NA-I223V and NA-S247N, in the 2023–2024 season, which both result in a slight reduction in susceptibility to NA inhibitors.
-
A(#H2N2) and A(#H3N2) #influenza #pandemics elicited durable cross-reactive and protective #antibodies against avian #N2 #neuraminidases, Nat Commun.: https://www.nature.com/articles/s41467-024-49884-9
The anti-AIV N2 antibodies titers correlate with antibody titers to the 1957 N2, suggesting that #exposure to the A(H2N2) virus contribute to this reactivity. These findings underscore the critical role of neuraminidase #immunity in #zoonotic and pandemic influenza #risk #assessment.
-
Increase of permissive secondary #antiviral #mutations in #evolution of #H1N1pdm09 #influenza virus #neuraminidases, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.18.599480v1
Accumulation of secondary permissive #substitutions in NA of H1N1pdm09 viruses increases probability of emergence of antiviral- #resistant viruses. It is crucial to closely monitor evolution of circulating influenza viruses & to develop additional antiviral drugs against different target proteins.