Live and recent posts from across the Fediverse tagged #neuraminidases, aggregated by home.social.
Increase of #Synergistic Secondary #Antiviral #Mutations in the #Evolution of #H1N1pdm09 #Influenza Virus #Neuraminidases, Vaccines: https://www.mdpi.com/1999-4915/16/7/1109
The data indicate a slight increase in viral NA bearing two additional potentially synergistic substitutions, NA-I223V and NA-S247N, in the 2023–2024 season, which both result in a slight reduction in susceptibility to NA inhibitors.
A(#H2N2) and A(#H3N2) #influenza #pandemics elicited durable cross-reactive and protective #antibodies against avian #N2 #neuraminidases, Nat Commun.: https://www.nature.com/articles/s41467-024-49884-9
The anti-AIV N2 antibodies titers correlate with antibody titers to the 1957 N2, suggesting that #exposure to the A(H2N2) virus contribute to this reactivity. These findings underscore the critical role of neuraminidase #immunity in #zoonotic and pandemic influenza #risk #assessment.
Increase of permissive secondary #antiviral #mutations in #evolution of #H1N1pdm09 #influenza virus #neuraminidases, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.06.18.599480v1
Accumulation of secondary permissive #substitutions in NA of H1N1pdm09 viruses increases probability of emergence of antiviral- #resistant viruses. It is crucial to closely monitor evolution of circulating influenza viruses & to develop additional antiviral drugs against different target proteins.
#Development and characterization of an #antibody that recognizes #influenza virus #N1 #neuraminidases https://pubmed.ncbi.nlm.nih.gov/38723016/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&fc=None&ff=20240510071413&v=2.18.0.post9+e462414
However, further validation is necessary to confirm whether FNA1 mAb is indeed a good inhibitor against NA for application against H1N1 and H5N1 viruses.