#nais — Public Fediverse posts

#Genotypic & #phenotypic susceptibility of emerging avian #influenza A viruses to
#NAIs & cap-dependent endonuclease #inhibitors, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224001682?via%3Dihub

Frequencies of markers of resistance to antivirals were low among >20,000 avian influenza A viruses studied. #H5Nx, #H7Nx, & #H9N2 viruses were susceptible to sub-nanomolar concentrations of antivirals. NA-I222M, but not NA-S246N or NA-I222V, in H5N1 confers reduced inhibition by #oseltamivir.

#Russia, According to genetic #analysis conducted in St. Petersburg, 9 A #H1N1pdm09 {#influenza} viruses had the H275Y #substitution in #neuraminidase responsible for resistance to #oseltamivir. NIC: https://www.influenza.spb.ru/en/influenza_surveillance_system_in_russia/epidemic_situation/ #antivirals #NAIs

''In 2022, flu #H3N2 viruses predominated over #H1N1pdm09 & B viruses, accounting for 77% of all viruses analysed. Majority of #H1N1pdm09, #H3N2 & flu B viruses analysed at Centre were found to be antigenically and genetically similar to respective #WHO recommended #vaccine #strains for the S hemisphere in 2022. Of 3,372 samples tested for susceptibility to the #NAIs #oseltamivir & #zanamivir, 2 H1N1pdm09 viruses showed highly reduced inhibition against oseltamivir.''