#mycobacterium — Public Fediverse posts

Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @PLOSBiology https://plos.io/4vG0mz1

Master Acid-Fast Staining techniques and identify Mycobacterium accurately with stepwise laboratory guidance from BioResire experts today.
#AcidFastStaining #MicrobiologyLab #Mycobacterium #LaboratoryTechniques #MedicalMicrobiology #ZiehlNeelsen #BiotechnologyStudents #LabSkills #LifeSciences #BioResire

✨ What secret molecular partnership helps mycobacteria stay alive when conditions turn deadly?

🔗 Structural modeling and biochemical characterization of MSMEG_0748, a MoxR ATPase from Mycobacterium smegmatis. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.010

📚 CSBJ: https://www.csbj.org/

#Mycobacterium #MoxR #ATPase #AlphaFold #StructuralBiology #Biophysics #Microbiology #MolecularModeling

#Antibiotika sind für #Pharma ein schlechtes Geschäft. So kennt man etwa BTZ-043, das den #Tuberkulose-Erreger #Mycobacterium tuberculosis effektiv ausschaltet, schon seit 20 Jahren. Doch Pharmafirmen interessieren sich nicht dafür … Karin Lauschke erzählt mehr: https://www.laborjournal.de/editorials/3221.php

#Bacterial species study challenges assumption that #structural similarity predicts #protein behavior

#Escherichia #Mycobacterium #cAMP #CRP #Allosteric #homology

https://phys.org/news/2025-02-bacterial-species-assumption-similarity-protein.html

#Bacterial species study challenges assumption that #structural similarity predicts #protein behavior

#Escherichia #Mycobacterium #cAMP #CRP #Allosteric #homology

https://phys.org/news/2025-02-bacterial-species-assumption-similarity-protein.html

#Bacterial species study challenges assumption that #structural similarity predicts #protein behavior

#Escherichia #Mycobacterium #cAMP #CRP #Allosteric #homology

https://phys.org/news/2025-02-bacterial-species-assumption-similarity-protein.html

#Bacterial species study challenges assumption that #structural similarity predicts #protein behavior

#Escherichia #Mycobacterium #cAMP #CRP #Allosteric #homology

https://phys.org/news/2025-02-bacterial-species-assumption-similarity-protein.html

Researchers reveal a hidden trait in #Mycobacterium #genomes governing #stress adaptation.

#transcriptional_plasticity

https://phys.org/news/2024-04-reveal-hidden-trait-mycobacterium-genomes.html

"Host cell environments and antibiotic efficacy in tuberculosis"

Nice figure showing the challenges of #antibiotics to get into a cell and target #Mycobacterium tuberculosis

#tuberculosis #TB #IDMastodon #infectiousdiseases #immunology
https://www.cell.com/trends/microbiology/fulltext/S0966-842X(23)00253-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0966842X23002536%3Fshowall%3Dtrue

In the most comprehensive study of its kind, the #research team from Surrey conducted a study on the #bacterium that causes #tuberculosis ( #TB ), called #Mycobacterium tuberculosis ( #Mtb ).
#Biology #Microbiology #Pharmaceutical #sflorg
https://www.sflorg.com/2023/03/bio03272303.html

Uptake-independent killing of macrophages by extracellular #Mycobacterium #tuberculosis aggregates

Chiara Toniolo et al show that Mtb aggregates evade #phagocytosis by inducing #macrophage #pyroptosis via a mechanism involving its type VII secretion system ESX-1 and surface lipid PDIM

https://www.embopress.org/doi/10.15252/embj.2023113490

"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"

#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis

https://www.cell.com/cell/fulltext/S0092-8674(22)01581-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015811%3Fshowall%3Dtrue

So, I found out what nearly killed me today from the doctor. Starting treatment today for the next 6 - 8 weeks.

#Mycobacterium #FishKeeping #Aquarium

https://en.wikipedia.org/wiki/Mycobacterium

My latest column for #NatureMedicine is a look at early human results of a new class of #antibiotics for #tuberculosis

The mechanism of action is essentially to clog the #mycobacterium's tRNA synthetase - the result of two decades of research on boron-based compounds.

#IDMastodon #DrugDevelopment
#antibioticresistance

https://www.nature.com/articles/d41591-022-00114-z

How does #Mycobacterium #tuberculosis transport nutrients across its outer membrane? Study shows that a member of the large PE/PPE protein family imports #calcium, suggesting family-wide role as atypical #bacterial nutrient transporters #TB #PLOSBiology https://plos.io/3ASpg3z

How does #Mycobacterium #tuberculosis transport nutrients across its outer membrane? Study shows that a member of the large PE/PPE protein family imports #calcium, suggesting family-wide role as atypical #bacterial nutrient transporters #TB #PLOSBiology https://plos.io/3ASpg3z

How does #Mycobacterium #tuberculosis transport nutrients across its outer membrane? Study shows that a member of the large PE/PPE protein family imports #calcium, suggesting family-wide role as atypical #bacterial nutrient transporters #TB #PLOSBiology https://plos.io/3ASpg3z

I spend one slide of my #microbiology lectures a year on #Mycobacterium leprae, usually in the context of its dysfunctional #genome & that it can only be cultivated in #armadillos. Plot twist: infection with these #leprosy #bacteria help promote host liver regeneration https://doi.org/10.1016/j.xcrm.2022.100820 #InArmadillos

I work at the intersection of #microbiology , #engineering , #risk and the #environment . Lots of work in #drinkingwater , #indoorairquality ( #IAQ ), #wastewaterreuse

organisms of current interest include:
#Legionella
#Mycobacterium
#COVID19

#fungi

Interested in #disinfection , #processmodeling, #neuralnetworks , #CFD

tools used:
#Matlab
#Rstats
#Python
#obsidian