#myc — Public Fediverse posts

New Paper out in @cellpress.bsky.social: How cancer cells protect themselves from the immune system. Cancer gene #MYC camouflages tumours by suppressing alarm signals. ‪@mycgyvers.bsky.social‬‬‬‬ @uni-wuerzburg.de
https://nachrichten.idw-online.de/2026/01/22/decoded-how-cancer-cells-protect-themselves-from-the-immune-system

Rally today at Foley Square in #MYC at 6 PM about the woman ICE killed in Minneapolis https://www.instagram.com/p/DTOPjMeCVWO/ #ICE #NewYork #HandsOffNYC #NoKings

New Publication from our LED3 hub!

The group of Sebastian Pomplun published "ReCHEMbinant stapling enhances intracellular delivery and bioactivity of engineered protein inhibitors" in the journal Chem.

https://www.sciencedirect.com/science/article/pii/S2451929425004309?via%3Dihub

#Chemistry #ChemBio #DrugDiscovery #MYC #Cancer

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#MYC #MADDEN26

Interesting paper by the group of Sebastian Pomplun of our @LED3hub in ChemMedChem. Based on the AlphaFold-Multimer structure of MYC/Miz-1, they designed a stapled peptide that disrupts the MYC/MAX interaction.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.202500740
#Chemistry #ChemBio #PPI #Myc #Cancer

Aviation weather for Escuela Mariscal Sucre airport in Maracay area (Venezuela) is “SVBS 302303Z AUTO NIL” : See what it means on https://www.bigorre.org/aero/meteo/svbs/en #maracay #venezuela #escuelamariscalsucreairport #svbs #myc #metar #aviation #aviationweather vl

Aviation weather for Escuela Mariscal Sucre airport in Maracay area (Venezuela) is “SVBS 301103Z AUTO NIL” : See what it means on https://www.bigorre.org/aero/meteo/svbs/en #maracay #venezuela #escuelamariscalsucreairport #svbs #myc #metar #aviation #aviationweather vl

Synthetic Miniproteins Inhibit “Undruggable” Cancer Drug Target

“DuoMYC” binds to the target DNA of the transcription factor MYC, which plays a role in over 50 % of all human cancers

https://www.chemistryviews.org/synthetic-miniproteins-inhibit-undruggable-cancer-drug-target/

#drugdevelopment #anticancer #ebox #myc #transcription factor #chemistry #chemistryviews #chemviews

Synthetic Miniproteins Inhibit “Undruggable” Cancer Drug Target

“DuoMYC” binds to the target DNA of the transcription factor MYC, which plays a role in over 50 % of all human cancers

https://www.chemistryviews.org/synthetic-miniproteins-inhibit-undruggable-cancer-drug-target/

#drugdevelopment #anticancer #ebox #myc #transcription factor #chemistry #chemistryviews #chemviews

Synthetic Miniproteins Inhibit “Undruggable” Cancer Drug Target

“DuoMYC” binds to the target DNA of the transcription factor MYC, which plays a role in over 50 % of all human cancers

https://www.chemistryviews.org/synthetic-miniproteins-inhibit-undruggable-cancer-drug-target/

#drugdevelopment #anticancer #ebox #myc #transcription factor #chemistry #chemistryviews #chemviews

Synthetic Miniproteins Inhibit “Undruggable” Cancer Drug Target

“DuoMYC” binds to the target DNA of the transcription factor MYC, which plays a role in over 50 % of all human cancers

https://www.chemistryviews.org/synthetic-miniproteins-inhibit-undruggable-cancer-drug-target/

#drugdevelopment #anticancer #ebox #myc #transcription factor #chemistry #chemistryviews #chemviews

Synthetic Miniproteins Inhibit “Undruggable” Cancer Drug Target

“DuoMYC” binds to the target DNA of the transcription factor MYC, which plays a role in over 50 % of all human cancers

https://www.chemistryviews.org/synthetic-miniproteins-inhibit-undruggable-cancer-drug-target/

#drugdevelopment #anticancer #ebox #myc #transcription factor #chemistry #chemistryviews #chemviews

4-JAN-2024
Scientists tame chaotic protein fueling 75% of cancers
Discovery opens window to more effective treatment

https://www.eurekalert.org/news-releases/1030250 #science #nanoworld #IntrinsicallyDisorderedProteins #myc #cancer #proteins #ProteinFolding

"Dark & Disordered", a tetraptych in the Dark Proteome series. #darkProteome #MYC

#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer

Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling

https://www.embopress.org/doi/10.15252/embj.2022112614

#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer

Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling

https://www.embopress.org/doi/10.15252/embj.2022112614

#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer

Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling

https://www.embopress.org/doi/10.15252/embj.2022112614

#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer

Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling

https://www.embopress.org/doi/10.15252/embj.2022112614

#YAP/#BRD4-controlled ROR1 promotes tumor-initiating cells and #hyperproliferation in #pancreaticcancer

Masaya Yamazaki et al show that #ROR1 marks an aggressive partial #EMT cell cluster and enhances #PDAC proliferation via c-#Myc/#E2F/#AURKB signaling

https://www.embopress.org/doi/10.15252/embj.2022112614

Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Genomic binding & transcriptional activation by #Myc are controlled by #TXNIP, whose expression is linked to cellular energy status, thereby connecting Myc transcriptional activity to cell #metabolism & nutrient status @yehpeace @GertzLab #PLOSBiology https://plos.io/3FCCJyV

Some new cancer news for y'all.

The MYC family of regulatory genes help control cell growth and proliferation and are known to be constantly on in cancerous cells.

Now, researchers at the University of Würzburg have found that these MYC proteins form into spheres under stressful conditions, thereby causing the proliferation.

Destroying them would also likely kill the cancer cell they belong to.

#Cancer #Biology #Medicine #MYC #sciencemastodon #scicomm

https://www.nature.com/articles/s41586-022-05469-4

#MYC #genes and their #proteins play a central role in the emergence and development of almost all #cancers. They drive the uncontrolled growth and altered metabolism of tumor cells. And they help tumors hide from the #immune system.
#Biology #Pharmaceutical #sflorg
https://www.sflorg.com/2022/11/bio11252202.html

Hello everyone, I'm a scientist who now writes about cool science in the oncology arena. Currently interested in #TPD #KRAS #MYC and other emerging areas of interest.