#mpro — Public Fediverse posts

Next-generation #inhibitors of #SARS-CoV-2 #Mpro overcome the deficiencies of #Paxlovid, https://etidiohnew.blogspot.com/2026/04/next-generation-inhibitors-of-sars-cov.html

A #clinical #SARS-CoV-2 #Mpro #inhibitor blocks replication of multiple #enteroviruses and confers oral in vivo protection in animal models, https://etidiohnew.blogspot.com/2026/03/a-clinical-sars-cov-2-mpro-inhibitor.html

#Structural and #virologic #mechanism of the emergence of #resistance to #Mpro #inhibitors in #SARS-CoV-2, PNAS: https://www.pnas.org/doi/abs/10.1073/pnas.2404175121?af=R

We generated SARS-CoV-2 variants resistant to three SARS-CoV-2 main protease (Mpro) inhibitors (#nirmatrelvir, TKB245, and 5h), by propagating the ancestral SARS-CoV-2WK521WT in VeroE6TMPRSS2 cells with increasing concentrations of each inhibitor and examined their structural and virologic profiles.

#Structural #basis of #mpro of #MERS-CoV bound to antineoplastic #drug #carmofur, Biochem Biophys Res Commun.: https://www.sciencedirect.com/science/article/abs/pii/S0006291X24010052?via%3Dihub

Highlights:
* The crystal structure of MERS-CoV Mpro in complex with carmofur.
* The structural basis of MERS-CoV Mpro binding to the inhibitor carmofur.
* Structural comparison of carmofur with SARS-CoV-2 Mpro and MERS-CoV Mpro.

Identification of #SARS-CoV-2 #Mpro #inhibitors containing P1’ 4-fluorobenzothiazole moiety highly active against SARS-CoV-2 https://www.nature.com/articles/s41467-023-36729-0

The team caught the moment when a #virus #protein, called #Mpro, cuts a protective protein, known as #NEMO, in an #infected person. Without NEMO, an #immune system is slower to respond to increasing #viral loads or new infections. Seeing how Mpro attacks NEMO at the molecular level could inspire new therapeutic approaches.
#Covid19 #Virology #sflorg
https://www.sflorg.com/2022/12/vi12092201.html