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#molecularmechanism — Public Fediverse posts

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  1. An interesting investigation of what happens when you deplete eRF1 from cells: more ribosomes rush into the 3'UTR. The paper also evaluates what the Gcn2 protein kinase can do under these conditions. I would think that the supplementary 3' UTR ribosomes when both eRF1 and Gcn2 are depleted is probably due to an excessive translation initiation. The authors also propose various alternative explanations of their findings.

    pubmed.ncbi.nlm.nih.gov/413712

    #RNA #translation #molecularmechanism #research

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