#membraneproteins — Public Fediverse posts

🧬 Can we trust membrane protein annotations when databases tell different stories?

🔗 MetaMP Ecosystem for Unified, Auditable, and Benchmark-Ready Data for Reliable Membrane Protein Annotation. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0165

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

#MembraneProteins #StructuralBiology #Bioinformatics #ComputationalBiology #ProteinScience #DataScience #DrugDiscovery #AIinScience #OpenScience

The structure of a chimeric efflux pump was determined by cryoEM under apo and kanamycin-supplemented conditions and adopted symmetric-like and asymmetric conformations #PseudomonasAeruginosa #DrugEffluxTransporters #MembraneProteins https://doi.org/10.1107/S2053230X26001202

🧩 What if the diverse functions of a single protein all trace back to one structural superfamily?

🔗 Evolutionary and structural bioinformatics identifies GPR89 as a conserved member of the LIMR protein superfamily. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.003

📚 CSBJ: https://www.csbj.org/

#StructuralBiology #ComputationalBiology #MolecularEvolution #ProteinScience #Genomics #Proteomics #AlphaFold #MembraneProteins #Genetics #Bioinformatics

🔬 Could a tiny imbalance in ATP binding be the key to drug resistance in cancer?

🔗 Nucleotide asymmetry and flexible linker dynamics modulate drug efflux cycle of P-glycoprotein, A computational study. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.10.064

📚 CSBJ: https://www.csbj.org/

#DrugResistance #MolecularDynamics #StructuralBiology #MembraneProteins #CancerResearch #Pharmacology #DrugDiscovery #ChemotherapyResistance #ProteinDynamics #Pgp #ABCB1 #Biophysics

Exploring ML + MD for membrane proteins: moving beyond manual inspection to detect events, change-points, and metastable states in long trajectories. Faster clustering, better patterns, fewer blind spots. Anyone pairing k-means with HELM or similar for refinement? 🤔

#MolecularDynamics #MachineLearning #Bioinformatics #MembraneProteins

https://is.gd/5Ycb2P

Postdoctoral Associate in Membrane Protein Structural Biology
Vecchio Lab at University at Buffalo

#postdoc in vecchio lab at university at buffalo department of #structuralbiology studying #membraneprotein #structureandfunction

See the full job description on jobRxiv: https://jobrxiv.org/job/university-at-buffalo-27778-postdoctoral-associate/

#biophysics #cryoEM #membraneproteins #proteinproteininter...
https://jobrxiv.org/job/university-at-buffalo-27778-postdoctoral-associate/?fsp_sid=2412

Postdoctoral Associate in Membrane Protein Structural Biology
Vecchio Lab at University at Buffalo

#postdoc in vecchio lab at university at buffalo department of #structuralbiology studying #membraneprotein #structureandfunction

See the full job description on jobRxiv: https://jobrxiv.org/job/university-at-buffalo-27778-postdoctoral-associate/

#biophysics #cryoEM #membraneproteins #proteinproteininter...
https://jobrxiv.org/job/university-at-buffalo-27778-postdoctoral-associate/?fsp_sid=1950

https://www.europesays.com/uk/360973/ Molecular mechanism of ultrafast transport by plasma membrane Ca2+-ATPases #CryoelectronMicroscopy #HumanitiesAndSocialSciences #MembraneProteins #multidisciplinary #Science #UK #UnitedKingdom

Nabla Bio: Revolutionizing Antibody Design Through Target Engineering

In a world saturated with antibody design startups, Nabla Bio emerges with a groundbreaking approach that focuses on engineering drug targets rather than the antibodies themselves. By tackling the cha...

https://news.lavx.hu/article/nabla-bio-revolutionizing-antibody-design-through-target-engineering

#news #tech #NablaBio #MembraneProteins #AntibodyEngineering

📝 Call for Papers: Special Issue on "Mechanistic insights into membrane protein dynamics and allostery: implications in drug discovery"

🔗Link to the 'Call for Papers': https://www.csbj.org/allostery

📊 Guest Editor:

🌟Prithviraj Nandigrami, Albert Einstein College of Medicine, USA

#membraneproteins #proteindynamics #proteinstructure #drugdiscovery #transmembranesignaling #molecularsimulation #therapeuticmolecules

Postdoc - Membrane Protein Transport into Cilia

University of Oxford

Exciting opportunity to join the Roberts group @Dunn_School to study how #membraneproteins are transported into #cilia using #cryoEM

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-oxford-27778-postdoc-membrane-protein-transport-into-cilia/?feed_id=59857

#ScienceJobs #hiring #res...
https://jobrxiv.org/job/university-of-oxford-27778-postdoc-membrane-protein-transport-into-cilia/?feed_id=59857

Introducing one-step/5 min. digests using new archaeal proteases for #proteomics. Generates #massspec data orthogonal to Trypsin, increasing peptide IDs and proteome coverage. Unique bias towards #membraneproteins. Read more in Journal of Proteomics (https://c-bio.link/jZFV9C)

Rock around the clock! Classic from Jonathan Ashmore. Eduardo Perozo tells us about prestin at the Dynion @dfg_public Symposium in Jena #MembraneProteins #hearing #electromotility

https://www.ucl.ac.uk/ear/research/ashmorelab

How is aggregation of #MembraneProteins regulated? @rachel_kandel @Neal_Lab &co show that yeast derlin Dfm1 has a #chaperone-like function that affects solubility of ER-resident misfolded membrane proteins #aging #neurodegeneration #PLOSBiology https://plos.io/3DaKk6u

How is aggregation of #MembraneProteins regulated? @rachel_kandel @Neal_Lab &co show that yeast derlin Dfm1 has a #chaperone-like function that affects solubility of ER-resident misfolded membrane proteins #aging #neurodegeneration #PLOSBiology https://plos.io/3DaKk6u

How is aggregation of #MembraneProteins regulated? @rachel_kandel @Neal_Lab &co show that yeast derlin Dfm1 has a #chaperone-like function that affects solubility of ER-resident misfolded membrane proteins #aging #neurodegeneration #PLOSBiology https://plos.io/3DaKk6u

Hi Everyone!

I'm a #Postdoc at #Stockholm University in the dept of #biochemistry and #biophysics. I study membrane protein folding using #CryoEM and other #MolecularBiology techniques.

I used to study protein–protein interactions in the membrane. Now my main project is on a voltage gated potassium channel, KvAP.

I'm new to mastodon but hoping this is a good place to meet people and talk about science!

#protein #proteinfolding #StructuralBiology #ionchannels #membraneproteins #introductions