#lysosome — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #lysosome, aggregated by home.social.
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Postdoc, PhD, Master
Ebner labJoin the Ebner lab to discover lysosomal lipid logistics pathways
See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/
#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=4848 -
Postdoc, PhD, Master
Ebner labJoin the Ebner lab to discover lysosomal lipid logistics pathways
See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/
#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=3455 -
Postdoc, PhD, Master
Ebner labJoin the Ebner lab to discover lysosomal lipid logistics pathways
See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/
#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=1096 -
Postdoc, PhD, Master
Ebner labJoin the Ebner lab to discover lysosomal lipid logistics pathways
See the full job description on jobRxiv: https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/
#battendisease #lipidtransport #lysosome #membranecontactsites #microglia #microscopy #neurodegeneration #repair #ScienceJobs #hiring #research
https://jobrxiv.org/job/ebner-lab-27778-postdoc-phd-master/?fsp_sid=39 -
Focus sur la Maladie de #Parkinson :
2 mécanismes de progression distinctes = 2 dysfonctionnements cellulaires.
-> la #mitochondrie : structure cellulaire générant l'énergie nécessaire aux cellules = aspects moteurs.
-> le #lysosome : organite cellulaire effectuant la digestion intracellulaire = troubles cognitifs #cerveau -
Uncovering the Ancient Origins of Key Immune Machinery https://www.ualberta.ca/en/department-of-medicine/news-events/department-news/2024/10/joel-dacks-uncovering-the-ancient-origins-of-key-immune-machinery.html
Evolutionary origins of the #lysosome-related #organelle sorting machinery reveal ancient homology in post-#endosome trafficking pathways: Kiran More et al. https://www.pnas.org/doi/10.1073/pnas.2403601121
"the BLOC machinery plays an important role in #microbes today for our ecosystem and health and may help to explain the #evolution of the basic cellular configuration over 1.5 billion years ago."
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"Our study demonstrates a unique role for MANF in autophagy and lysosome function, critical processes for clearing toxic proteins. In the animal model Caenorhabditis elegans, overexpressing MANF extended lifespan, reduced protein clumps, and conferred protection on neurons. These roles of MANF are mediated by the HLH-30/TFEB, a master regulator of lysosome function"
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LAMP1 protein-tracking with clever use of proximity labeling reveals neuron-specific Lysosomal function.
Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons
Li et al., preprint at biorxiv 2024
https://www.biorxiv.org/content/10.1101/2024.05.16.594502v1?ct=
#preprint #neuroscience #proteomics #lysosome -
Is it worth repairing the #lysosome? Or better dissolve it? Biologists @unidue have identified a new #signaling pathway through which our cells make this decision. They published their results in @MolecularCell.
https://nachrichten.idw-online.de/2024/04/08/decomposition-of-damaged-lysosomes-new-signaling-pathway-decoded -
Single-organelle resolution approaches have the potential to advance our knowledge of the heterogeneity of #lysosome function.
@maxgabgut &co propose a 'lysosome states' concept that links single lysosomes to function.
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Failure of #ProteinQC in #Celegans triggers a mechanism involving pathogen response factors & #lysosome-mediated degradation, promoting tissue-specific resilience to age-dependent #ProteinAggregation & #proteotoxicity @DellaDavid_Lab &co #PLOSBiology https://plos.io/44QeDdD
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TFEB-dependent lysosome biogenesis is required for #senescence
by Bernadette Carroll and coworkersTranscription factor #TFEB induces #lysosome proliferation in #senescent cells, counterbalancing reduced lysosomal efficiency and maintaining #autophagic capacity
https://www.embopress.org/doi/10.15252/embj.2022111241 -
TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn
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TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn
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TFEB is a master controller of #lysosome biogenesis & #autophagy. This study identifies EGR1 as a positive regulator of #TFEB expression, revealing the function of the EGR1-TFEB transcriptional axis in physiology & disease @Tigem_Telethon #PLOSBiology https://plos.io/3J5hcjn
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Are you ready for your reading list for the week?
Check out this week's edition of publications on #MembraneContactSites!
http://biomed.news/bims-mecosi/2023-01-29
Thanks to #BioMedNews, an abstract-selection tool based on #ArtificialIntelligence and #MachineLearning!
