#lsd1 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #lsd1, aggregated by home.social.
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LSD1 (KDM1A) demethylates H3K4me1/2 via FAD-dependent oxidation — removing active enhancer/promoter marks and licensing transcriptional repression.
In the CoREST complex, it couples demethylation to HDAC1/2-mediated deacetylation for compounded silencing.
LSD1 inhibition extends lifespan in model organisms. The local H₂O₂ byproduct at demethylation sites may be a redox signal — the full mechanistic picture isn't resolved yet.