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#linkagedisequilibrium — Public Fediverse posts

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  1. ‘Vertical’ #pleiotropy is when a variant affects a phenotype that has its own downstream effects on another phenotype

    ‘Horizontal’ pleiotropy is where a variant has multiple independent effects; no phenotype mediates another

    Needless terminology! Easily represented in simple #DAGs as chaining and common cause, respectively. #Genetics should avoid making up new terms for simple stuff.

    The interesting twist for genetics is #LinkageDisequilibrium because it can masquerade as pleiotropy