#kp2 — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #kp2, aggregated by home.social.
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#Effectiveness of the 2024–2025 #KP2 #COVID19 #vaccines in #USA during long-term follow-up, https://etidiohnew.blogspot.com/2025/12/effectiveness-of-20242025-kp2-covid19.html
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Kore Potash DRC ( #KP2 ) has released " Kola Optimisation Study Update " on Thu 27 Feb at 19:39 AEST #Inflation #Russia #tax #government #Commodity
https://grafa.com/asset/kore-potash-ltd-drc-25813-kp2.asx?utm_source=asxmktsensitive&utm_medium=mastodon&utm_campaign=kp2.asx -
Kore Potash DRC ( #KP2 ) has released " Confirmation of Mineral Resource for Kola Deposit " on Thu 27 Feb at 19:33 AEST #today #Russia #government #Mining #Australia
https://grafa.com/asset/kore-potash-ltd-drc-25813-kp2.asx?utm_source=asxmktsensitive&utm_medium=mastodon&utm_campaign=kp2.asx -
Gibt es eigentlich Studien darüber,
a) welche Wirkung es genauer hat, wenn man 7, 8, 9 … Mal geimpft ist;
b) welche Wirkung eine Impfung auf den Verlauf hat, wenn man sich zufällig kurz darauf infiziert?
Beide Fragen scheinen eher unbeachtet.
#CovidIsNotOver #ImpfenSchützt #Kontrollgruppe #Corona #jn1 #kp2
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#Neutralization of #SARS-CoV-2 #KP1, #KP11, #KP2 and #KP3 by #human and murine #sera
Source: npj Vaccines, AbstractWe report SARS-CoV-2 KP.1, KP.1.1, KP.2 and KP.3 neutralizing antibody titers. They displayed increased immune evasion compared to JN.1, especially KP.1 and KP.3, for participants who experienced BF.7/BA.5.2 breakthrough infection or received bivalent (delta/BA.5) vaccine boosting. Second XBB sub-variants breakthrough infection enhanced the neutralization…
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#Immunologic and Biophysical #Features of the #BNT162b2 #JN1 – and #KP2-Adapted #COVID19 #Vaccines
Source: BioRxIV, AbstractVaccines remain a vital public health tool to reduce the burden of COVID-19. COVID-19 vaccines that are more closely matched to circulating SARS-CoV-2 lineages elicit more potent and relevant immune responses that translate to improved real-world vaccine effectiveness. The rise in prevalence of the Omicron JN.1 lineage, and subsequent derivative…
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Neuer Impfstoff #Comirnaty KP.2 trifft in Österreich ein
https://orf.at/stories/3372835/
#KP2 #SARSCOV2 #Impfung -
Good news - Health Canada has just announced its approval of the new Moderna Covid vaccine, which targets the KP.2 variant. https://covid-vaccine.canada.ca/ #Covid19 #Covid #vaccine #Canada #HealthCanada #kp2 #Spikevax
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Structural and molecular #basis of the #epistasis effect in enhanced affinity between #SARS-CoV-2 #KP3 and #ACE2 http://biorxiv.org/cgi/content/short/2024.09.03.610799v1?rss=1
KP.3, featuring F456L and Q493E, exhibits a markedly enhanced ACE2 binding affinity compared to #KP2 and #JN1 #variant due to synergistic effects between these mutations.
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Today, the U.S. Food and Drug Administration approved and granted emergency use authorization ( #EUA ) for
❇️ updated #mRNA #COVID19 #vaccines (2024-2025 formula)
to include a monovalent (single) component that corresponds to the Omicron variant #KP2 strain of SARS-CoV-2.
The mRNA COVID-19 vaccines have been updated with this formula to more closely target currently circulating variants and provide better protection against serious consequences of COVID-19,
including hospitalization and death.Today’s actions relate to updated mRNA COVID-19 vaccines manufactured by #ModernaTX Inc. and #Pfizer Inc.
In early June, the FDA advised manufacturers of licensed and authorized COVID-19 vaccines that the COVID-19 vaccines (2024-2025 formula) should be monovalent JN.1 vaccines.
Based on the further evolution of SARS-CoV-2 and a rise in cases of COVID-19, the agency subsequently determined and advised manufacturers that the preferred JN.1-lineage for the COVID-19 vaccines (2024-2025 formula) is the KP.2 strain, if feasible.
https://www.fda.gov/news-events/press-announcements/fda-approves-and-authorizes-updated-mrna-covid-19-vaccines-better-protect-against-currently -
New #covid #vaccines for summer variants slated for approval late next week
The arrival of updated #Pfizer-BioNTech and new #Moderna vaccines for the #KP2 variant comes well into a summer wave when
💥Americans have struggled to find an existing shot.💥Consumers should be able to start getting shots at pharmacies within a week after approval
-- and at doctor’s offices soon after.
FDA spokespeople said the agency is prohibited from disclosing the timing of a regulatory action.The Centers for Disease Control and Prevention recommends updated shots for everyone 6 months and older.
https://www.washingtonpost.com/health/2024/08/16/new-covid-vaccine-pfizer-moderna-flirt-variant/
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[Correspondence] Virological #characteristics of the #SARS-CoV-2 #KP311 #variant https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(24)00505-X/fulltext?rss=yes
SARS-CoV-2 #JN1 variant (#BA28611), arising from BA.2.86.1 with spike protein (S) substitution S:L455S, outcompeted previously predominant #XBB lineages by beginning of 2024. Subsequently, JN.1 subvariants including #KP2 (JN.1.11.1.2) & #KP3 (JN.1.11.1.3), which acquired additional S substitutions (eg, S:R346T, S:F456L, and S:Q493E) have emerged concurrently (appendix pp 19–20).2
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#Pemivibart is less active against recent #SARS-CoV-2 #JN1 #sublineages http://biorxiv.org/cgi/content/short/2024.08.12.607496v1?rss=1
Pemivibart neutralized both JN.1 and #KP2 in vitro with comparable activity, whereas its potency was decreased slightly against #LB1, #KP23, and #KP3 but substantially against #KP311. Critically, the 50% inhibitory concentration of pemivibart against KP.3.1.1 was ~6 g/mL, or ~32.7 fold higher than that of JN.1.
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An upcoming #vaccine from the biotech co Novavax will target #JN1, a #coronavirus #variant that accounted for the bulk of cases in the #UnitedStates this winter. The Pfizer & Moderna shots coming this fall will target #KP2, a newer offshoot of JN.1 that’s been circulating this summer. The #variants responsible for the largest share of cases in the #US right now, #KP3 & #KP311, are closely related to KP.2 & JN.1.
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July sees rise in #COVID19 cases in #China, https://www.globaltimes.cn/page/202408/1317754.shtml
Since early June, #XDV1 and #KP2 series of the #Omicron variant have been detected at higher rates, with XDV.1 rising to 40-50 percent of cases. However, these variants have not led to a rise in severe cases, as shown by Chinese CDC data.
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Falls sich jemand fragt ob Moderna seinen C19 Impfstoff für den Herbst jetzt auf JN.1 oder KP.2 ausrichten wird: Offenbar beides.
Quelle: Aussagen von Moderna bei der Veröffentlichung der Quartalszahlen vor einigen Tagen.
„Moderna has manufactured vaccines targeting KP.2 and JN.1 strains of the virus and is prepared to meet the 2024/2025 respiratory virus season demand“
https://s29.q4cdn.com/435878511/files/doc_earnings/2024/q2/presentation/Moderna-2Q24-Earnings-Presentation-Final.pdf
#Moderna #Spikevax #Impfung #C19 #JN1 #KP2 -
Nuevas #variantes de #covid19 circulan en #Guatemala https://boletinaldia.sld.cu/aldia/2024/07/27/nuevas-variantes-de-covid-19-circulan-en-guatemala/
La cartera sanitaria refirió un reciente informe de la dirección del Laboratorio Nacional que confirmó por primera vez las cepas #KP y sus sublinajes #KP11, #KP113, #KP2, #KP22, #KP23, #KP323.
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Nueva #variante #FLiRT de la #covid19 circula en #Ecuador https://boletinaldia.sld.cu/aldia/2024/07/05/nueva-variante-flirt-de-la-covid-19-circula-en-ecuador/
El Ministerio de Salud Pública de Ecuador confirmó hoy que la nueva variante #KP2 (FLiRT) del virus Sars-Cov-2, causante de la Covid-19, ya circula en el país andino.
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''The #Re of #KP3 was more than 1·2-fold higher than that of #JN1 and higher than or similar to that of #KP2 in these countries. Notably, the Re values of #LB1 and #KP23 were higher than those of KP.2 and KP.3. These results suggest that the three #variants we investigated will spread worldwide, in addition to KP.2.2''
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#France, #Covid19 : une #circulation virale accrue, boostée par le nouveau sous- #variant #KP2 https://www.lemonde.fr/planete/article/2024/06/19/covid-19-une-circulation-virale-accrue-boostee-par-le-nouveau-sous-variant-kp-2_6241436_3244.html
Ce sous-variant issu de #JN1 montre un échappement immunitaire plus important, sans pour autant provoquer des formes plus sévères de la maladie.
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Jun 15 [Translated: ] Puerto Rico registers the highest peak of COVID-19 positivity this Saturday (El Nuevo Dia | Puerto Rico) -
[Translated: ] Less than two weeks ago, Salud confirmed to El Nuevo Día that, among the infections of this respiratory virus, a new variant called KP.2 predominated...
...currently, 184 people are hospitalized for COVID-19 in Puerto Rico, including 23 pediatric cases...
#COVID #KP2 #FLiRTVariant #publichealth #longcovid #puertoRico
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FDA empfiehlt nun #KP2 anstatt #JN1-#Impfstoff bereitzustellen.
https://www.fda.gov/vaccines-blood-biologics/updated-covid-19-vaccines-use-united-states-beginning-fall-2024 -
Good Muggy Morning SARS2PAians! ☁️💐☁️
I hope you are having a safe Spring!
The top news lately are the newest variants causing country-wide summer waves including Spain: https://ibb.co/hRpvjt5
and Portugal: https://ibb.co/khTtyJX
They are KP.3.x.y and LB.x.y.
These new immune evasive variants are filling up hospitals and causing notable increases in deaths.
KP.3 is now the variant "grandfather" that is the fastest, the most immune evasive, and the most easily bound to cells. Specifically, the most watched upcoming variant is its grandchild, KP.3.1.1.
The newest variants that have a very good chance of causing a sizeable increase in numbers, if not a full blown-out wave, are variants of KP.3 that already have immune evasive mutations (FLuQE) but also have an advantageous specific spike deletion (S:S31del).
These new and fastest variants are immune evasive to BOTH current vaccinations, AND prior infections.
Nationally, KP.2 is still just barely at the top of the leaderboard. KP.2.3 is right behind it, already a variant that is being watched.: https://ibb.co/p0d8G8n
🔴KP.3.1.1 is absolutely blazing fast and burning through Spain, Portugal and other countries, and is part of KP-DEL31.
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NOTE: "KP-DEL31" is gonna be my nickname for it, not variant hunters or virologists. Just to call it something easily condensed and recognizeable for now. They might decide on a different nickname soon. These names are just for convenience. (You don't call your cousin Mister James Robert Smith every time, do you? You call him JimBob or Smitty. It just makes talking easier.)
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I've highlighted FLiRT in pink on the national screenshot but I'll drop it soon as KP-DEL31 becomes more and more relevant.
There's no specific results for PA on the Tableau site. Probably not enough testing here.
In NY/NJ, I've highlighted KP-DEL31 in green on the NY/NJ leaderboard, and as you can see, all the top 5 variants there have this very important spike deletion. But KP.3.1.1 is the variant to keep eyes on.: https://ibb.co/Jcv0rF7
KP.3.1.1 is already found (in only a few days!) in TX, NY, CA, CO, NJ, WA, and VA.
🔴If you've dropped wearing respirators for now you might want to reconsider putting them back on as KP.3.1.1 makes gains and spring moves along.
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Wastewater has returned to HIGH levels in the Eastern and Southern states. KP.2, KP.3 and LB.x.y variants are working together on driving this.: https://ibb.co/0nHqQPS
In our region, specifically testing in Maryland is showing a return to higher levels.: https://ibb.co/99MSpy0
The PA wastewater dashboard is showing LARGE increases in Philly, and sizeable increases in Centre and Indiana counties.: https://ibb.co/0J14Tty
MASK UP, oh my Philly ❤️️!
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Whoa I had a whole angry thing typed out here and juuuuuuust checked back on Twitter, and Dr. Eric Topol wrote just 2 hrs ago that the US FDA has changed its decision for the upcoming vaccine base!!: https://ibb.co/xzB6GVb
The newest mRNA vaccines will be based on KP.2 and NOT JN.1!
This is a wise decision and fantastic news!!
This will certainly better prepare us for Summer.
(NOTE: **Novavax** will have a JN.1 based booster. Novavax is completely different as it has proven effective through multiple years with ONE base so that vaccine will probably not have to be changed as often.)
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🔴Even with vaccines, there are always other things we can do to practice source control!keep those windows OPEN
wear a respirator
keep the air clean
move meetings outside
work from home
build a Corsi-Rosenthal box
stay home if you are sick!
Continue to have a great and safe Spring!! 💐💐💐
#COVID19 #COVID #COVIDisNotOver #SARS2PA #Pennsylvania #PA
#FLiRT #F456L #R346T #spike_f456l #spike_r346t
#FLuQE #Q493E
#KP2 #KP3 #LB1 #Moderna #Pfizer #Novavax
#WearAMask #CleanTheAir #WashHands #VaccinesSaveLives #StayHomeIfSick ! -
Update for 6/7/2024!
Good morning SARS2PAians!
I hope you're enjoying this beautiful Spring 💐💐💐
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VOCsNationally, KP.2 barely holding on to the top slot on the leaderboard at 8.22%. Fast, immune-evasive LB.1 is directly behind and most likely will take over in a week or less.: https://ibb.co/Q6ZZhsN
Immune-evasive KP.3 is also on the way up.
In PA, KP.3 and LB.1 has not been found in hte (horribly low) random testing we're doing. LB.1 did show up earlier, and "not finding" doesn't mean it's not around, but to not find such a fast variant in qualtities to put it on the PA board is promising.: https://ibb.co/ZN8Nrfp
In NY/NJ, LB.1 has easily displaced KP.2 for the top slot, with LB.1 at almost 17% of share and KP.2 behind at 9%.: https://ibb.co/mRR03KB
Lots of new mutations added in the past few weeks to the latest CDC NOWCAST.: https://ibb.co/b7y1mXb
Even on here, KP.3 is shown to be predicted as the TOP circulating variant, with KP.2 sandwiched between it and also-new-and-evasive LB.1.
Due to antigenic drift/effective ACE2 binding/communal laxness in prevention, this is probably going to bump numbers up for the summer.
Eevn though numbers a still low nationally, Walgreens COVID19 dashboard has already had large increases of positivity in a large number of States.: https://ibb.co/WHcFZK3
Pennsylvania has been considered at a large increase for quite a while already on there.: https://ibb.co/mc0CbPq
JN.1.50, KP.3.2 and KP.2.3 (yes those numbers are weirdly reversed) are also very fast, very immune-landscape-elusive mutes to watch, too.
I hope that I'm wrong but it seems that we'll be drowning in a soup of fast varaints for the fall/winter. My opinion only: This winter might be...something else...if the wrong vaccine formula is used.
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WastewaterThough numbers in PA are still relatively low, WastewaterSCAN has SARS2 levels at MEDIUM. Maryland/DC is starting to tick upward fast.: https://ibb.co/55JvPbt
PA WSS has McKean County showing heavy SARS2 material increases in wastewater, and moderstew increases in Philly.: https://ibb.co/8Pdz6MR
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Vaccine NewsThe most reliable viral geneticists and epidemiologists I'm watching has already said a JN.1 vaccine will be outdated.: https://ibb.co/vBgbr2g
🔴THIS IS NOT DUE TO VACCINES BEING INHERENTLY INEFFECTIVE. Do not spread that disnformation.
This is due to the superfast antigenic drift of SARS2, and also us being too slow to communally react to this virus. If a JN.1 vaccine is produced it will hardly effect any useful protection at all.: https://ibb.co/1dFTRKm
The fast rate which this virus gains mutations is absolutely not slowing down, and will most likely never slow down.
It is VITAL that corporate science (as in, the corporate producers of vaccines) keep up with mutations and if need be, drop outdated mutation bases FAST to change formula to one that will actually work effectively.
It is NECESSARY to even being the conversation now with KP.2.
We cannot afford to be slow in considering vaccination formulas or distribution.
Keeping the air clean is decidedly easier in better weather, but if numbers are going up in your area, PLEASE use some sort of source control. Wear a quality respirator, stay home if you are sick, test repeatedly with symptoms!
Enjoy your Spring and keep that air clean! 💐💐💐
#COVID19 #COVID #COVIDisNotOver #SARS2PA #Pennsylvania #PA #FLiRT #F456L #R346T
#spike_f456l #spike_r346t
#Q493E#WearAMask #CleanTheAir #WashHands #VaccinesSaveLives #StayHomeIfSick !
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Serious question.
Are the people who are ignoring #covid not catching it?
Unless you're in the small number who continue to be #vaccinated your previous #Covid19vaccinations are unlikely to be effective (especially since it's changed so much e.g. #JN1, #FLiRT & #KP2).
It seems odd to me that #immunity through getting the #disease is lauded as #protection. It's not said about #measles or #chickenpox (& I do know the differences in these #diseases)?
https://time.com/6898943/is-covid-19-still-pandemic-2024/
#COVID19 #LongCovid -
🇨🇦 Canada: New COVID-19 subvariants become the dominant strains in Canada.
"These new subvariants, known as KP.2 and KP.3, are under the Omicron umbrella, a type of mutation from the COVID-19 virus itself. They've spread so quickly that, as of May 19, 49.2 per cent of COVID-19 cases in Canada involve one of the strains."
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#Singapore, #Clinics pump in more #resources to combat spike in #COVID19 cases, respiratory #infections https://www.channelnewsasia.com/singapore/covid19-respiratory-infections-surge-kp1-kp2-flirt-variant-clinics-doctors-resources-4366136
Singapore has seen a jump in COVID-19 infections in recent weeks, with the new #KP1 and #KP2 strains, part of the family of “#FLiRT” #variants, accounting for about two-third of the cases.
