#intranasal — Public Fediverse posts

Current #status of #intranasal and inhaled #COVID19 #vaccines, https://etidiohnew.blogspot.com/2026/04/current-status-of-intranasal-and.html

An #intranasal adjuvanted, recombinant #influenza A/ #H5 #vaccine primes against diverse #H5N1 clades: a phase I trial, https://etidiohnew.blogspot.com/2025/11/an-intranasal-adjuvanted-recombinant.html

A single-dose #intranasal #immunization with a novel #bat #influenza A virus-vectored #MERS #vaccine provides effective protection against lethal MERS-CoV challenge, https://etidiohnew.blogspot.com/2025/07/a-single-dose-intranasal-immunization.html

Immunogenicity and protective #efficacy of an #intranasal NA-based #influenza virus #vaccine adjuvanted ..., https://etidiohnew.blogspot.com/2025/02/immunogenicity-and-protective-efficacy.html

Looking for the part that says in humans instead of in mice. But seeing "mucosal Immunity" was particularly gratifying.

https://scitechdaily.com/needle-free-new-nano-vaccine-effective-against-all-covid-19-variants/
https://onlinelibrary.wiley.com/doi/10.1002/advs.202404159
https://onlinelibrary.wiley.com/doi/pdf/10.1002/advs.202404159

#human #vaccine #COVID-19 #intranasal #mucosalImmunity

#Intranasal #hemagglutinin protein #boosters induce robust mucosal #immunity and cross-protection against #influenza A viral challenge

Source: BioRxIV, AbstractLicensed parenteral influenza vaccines induce systemic antibody responses and alleviate disease severity but do not efficiently prevent viral entry and transmission due to the lack of local mucosal immune responses. Here, we describe intranasal booster strategy with unadjuvanted recombinant hemagglutinin (HA)…

https://etidioh.wordpress.com/2024/10/15/intranasal-hemagglutinin-protein-boosters-induce-robust-mucosal-immunity-and-cross-protection-against-influenza-a-viral-challenge/

A single-dose #intranasal live-attenuated codon deoptimized #vaccine provides broad #protection against #SARS-CoV-2 and its #variants, Nat Commun.: https://www.nature.com/articles/s41467-024-51535-y

Current SARS-CoV-2 vaccines require several injections for optimal immune protection. Here, the authors report an intranasal live-attenuated vaccine that induces long-term immunity following a single dose and protects from SARS-CoV-2 wildtype and variants in non-human primate and small animal models.

#Intranasal administration of 8-valent next-generation #flu #vaccine elicits protective immune responses vs seasonal and #prepandemic viruses, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00354-24?af=R

8-valent COBRA vaccine elicited #antibodies that recognized a broad panel of strains representing different subtypes, & these vaccinated animals were protected vs flu virus challenges. This study demonstrated that mixture of 8 COBRA HA/NA proteins mixed with an intranasal adjuvant is a promising candidate vaccine.

#Intranasal M2SR (#M2-deficient Single Replication) #Influenza #Vaccine Induces Broadly Reactive #Mucosal #Antibody Production in Adults, J Infect Dis.: https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiae361/7714804?redirectedFrom=fulltext&utm_source=advanceaccess&utm_campaign=jid&utm_medium=email

These data suggest that M2SR induces broadly cross-reactive mucosal immune responses which may provide better protection against drifted and newly emerging influenza strains.

An #intranasal live-attenuated #SARS-CoV-2 #vaccine limits virus #transmission https://www.nature.com/articles/s41467-024-45348-2

This could be pretty interesting: AstraZeneca, which makes the #intranasal flu vaccine #FluMist, has applied to #FDA to allow the vaccine to be administered at home, by adults eligible to get it or old enough to give it to eligible kids. Decision pending; watch this space. https://www.statnews.com/2023/10/24/astrazeneca-maker-of-flumist-seeks-to-allow-at-home-administration-of-vaccine/

A next-generation #intranasal trivalent MMS #vaccine induces durable and broad #protection against #SARS-CoV-2 #variants of concern, PNAS: https://doi.org/10.1073/pnas.2220403120 #research #animal #models #science #library #covid19

@Scienceisnotopinions

Hope so, too.

But I'm not picky. I'll take whichever of the next generation #vaccines will be available first.

Could be #Codagenix, which is #intranasal. They are quite far with their testing, backed by the WHO.

https://www.clinicaltrialsarena.com/news/codagenix-sii-covid-vaccine-trial/

#Covid

India Tribune reports: "World's 1st intranasal Covid-19 shot now available as booster in private centres at nominal cost" http://www.tribuneindia.com/news/nation/worlds-1st-intranasal-shot-now-available-as-booster-in-private-centres-at-nominal-cost-463890 "Adults inoculated with two doses of Covaxin or Covishield will be now able to take the world's first intranasal Covid-19 shot manufactured by the Hyderabad-based Bharat Biotech as a booster dose from today with the Ministry of Health approving its inclusion in the national inoculation drive." #covid #booster #intranasal

GREAT NEWS!

#Intranasal #Covid19 vaccine #iNCOVACC approved as a booster in India!

#iNCOVACC was already approved for primary course vaccination in September.

I am eagerly waiting for data on mucosal antibodies.

Here is a Twitter-Thread (sorry, was before Mastodon😁) of mine with data on blood sera antibodies:

https://twitter.com/CoronaZeroCH/status/1581286466797592581

@erictopol @yaneerbaryam

THIS could become an absolute game changer for #Covid. I've been waiting for a year now for such news.

RT @[email protected]

1
Good news!

@[email protected], is hopeful of getting regulatory licenses this month for a #covid19 #intranasal #vaccine, if all goes well.

@[email protected] @[email protected] @[email protected] @[email protected]

Source:
https://www.tribuneindia.com/news/coronavirus/bharat-biotech-expects-regulators-nod-for-intranasal-covid-19-vaccine-this-month-418104

🐦🔗: https://twitter.com/CoronaZeroCH/status/1554394080557387778