#intranasal — Public Fediverse posts

https://www.europesays.com/es/552570/ Una vacuna intranasal muestra actividad en un modelo de cáncer colorrectal #actividad #cáncer #colorrectal #consigue #dianas #ES #España #esquivas #generar #Health #inmunitaria #innovadora #intranasal #modelo #muestra #Oncología #proteína #respuesta #Salud #Spain #terapéuticas #terapia #vacuna

Immunogenicity and protective #efficacy of an #intranasal NA-based #influenza virus #vaccine adjuvanted ..., https://etidiohnew.blogspot.com/2025/02/immunogenicity-and-protective-efficacy.html

#Intranasal #hemagglutinin protein #boosters induce robust mucosal #immunity and cross-protection against #influenza A viral challenge

Source: BioRxIV, AbstractLicensed parenteral influenza vaccines induce systemic antibody responses and alleviate disease severity but do not efficiently prevent viral entry and transmission due to the lack of local mucosal immune responses. Here, we describe intranasal booster strategy with unadjuvanted recombinant hemagglutinin (HA)…

https://etidioh.wordpress.com/2024/10/15/intranasal-hemagglutinin-protein-boosters-induce-robust-mucosal-immunity-and-cross-protection-against-influenza-a-viral-challenge/

#Intranasal administration of 8-valent next-generation #flu #vaccine elicits protective immune responses vs seasonal and #prepandemic viruses, J Virol.: https://journals.asm.org/doi/full/10.1128/jvi.00354-24?af=R

8-valent COBRA vaccine elicited #antibodies that recognized a broad panel of strains representing different subtypes, & these vaccinated animals were protected vs flu virus challenges. This study demonstrated that mixture of 8 COBRA HA/NA proteins mixed with an intranasal adjuvant is a promising candidate vaccine.

#Intranasal M2SR (#M2-deficient Single Replication) #Influenza #Vaccine Induces Broadly Reactive #Mucosal #Antibody Production in Adults, J Infect Dis.: https://academic.oup.com/jid/advance-article-abstract/doi/10.1093/infdis/jiae361/7714804?redirectedFrom=fulltext&utm_source=advanceaccess&utm_campaign=jid&utm_medium=email

These data suggest that M2SR induces broadly cross-reactive mucosal immune responses which may provide better protection against drifted and newly emerging influenza strains.

This could be pretty interesting: AstraZeneca, which makes the #intranasal flu vaccine #FluMist, has applied to #FDA to allow the vaccine to be administered at home, by adults eligible to get it or old enough to give it to eligible kids. Decision pending; watch this space. https://www.statnews.com/2023/10/24/astrazeneca-maker-of-flumist-seeks-to-allow-at-home-administration-of-vaccine/