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#inflammasome — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #inflammasome, aggregated by home.social.

  1. What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology plos.io/42FTqFO

  2. `Through unbiased analyses of #RNA and protein profiles in #Inositol polyphosphate-5-phosphatase D (INPP5D) -disrupted iPSC-derived human #microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted #autophagy and #inflammasome activation.. findings provide insights into the molecular mechanisms underlying microglia-mediated processes in #AD and highlight the inflammasome as a potential #therapeutic target`

    nature.com/articles/s41467-023

  3. 'Gefitinib (GF), the tyrosine kinase inhibitor (TKI) targeting epidermal growth factor receptor, initiates lung #inflammation through the NLR family pyrin domain containing 3 (NLRP3) inflammasome. However, the molecular targets and mechanisms underlying the inflammatory action of GF remain unknown. In this study, we identified mitochondrial Src family kinases (mSFKs) as key determinants of GF-induced #NLRP3 #inflammasome activation.'

    journals.aai.org/jimmunol/arti