#inflammasome — Public Fediverse posts

Polyphenol-rich extra-virgin olive oil influences bioenergetics and may modulate NLRP3 inflammasome in PBMCs from children and adolescents with obesity https://www.diningandcooking.com/2753832/polyphenol-rich-extra-virgin-olive-oil-influences-bioenergetics-and-may-modulate-nlrp3-inflammasome-in-pbmcs-from-children-and-adolescents-with-obesity/ #biochemistry #CellBiology #ChildrenObesity #diseases #Endocrinology #ExtraVirginOliveOil #HumanitiesAndSocialSciences #Inflammasome #MedicalResearch #Mediterranean #MediterraneanOliveOil #Mitochondria #multidisciplinary #NLRP3 #Olive #OliveOil #PBMCs #physiology #polyphenols #science

Polyphenol-rich extra-virgin olive oil influences bioenergetics and may modulate NLRP3 inflammasome in PBMCs from children and adolescents with obesity https://www.diningandcooking.com/2753832/polyphenol-rich-extra-virgin-olive-oil-influences-bioenergetics-and-may-modulate-nlrp3-inflammasome-in-pbmcs-from-children-and-adolescents-with-obesity/ #biochemistry #CellBiology #ChildrenObesity #diseases #Endocrinology #ExtraVirginOliveOil #HumanitiesAndSocialSciences #Inflammasome #MedicalResearch #Mediterranean #MediterraneanOliveOil #Mitochondria #multidisciplinary #NLRP3 #Olive #OliveOil #PBMCs #physiology #polyphenols #science

Polyphenol-rich extra-virgin olive oil influences bioenergetics and may modulate NLRP3 inflammasome in PBMCs from children and adolescents with obesity https://www.diningandcooking.com/2753832/polyphenol-rich-extra-virgin-olive-oil-influences-bioenergetics-and-may-modulate-nlrp3-inflammasome-in-pbmcs-from-children-and-adolescents-with-obesity/ #biochemistry #CellBiology #ChildrenObesity #diseases #Endocrinology #ExtraVirginOliveOil #HumanitiesAndSocialSciences #Inflammasome #MedicalResearch #Mediterranean #MediterraneanOliveOil #Mitochondria #multidisciplinary #NLRP3 #Olive #OliveOil #PBMCs #physiology #polyphenols #science

https://www.europesays.com/ie/560923/ Smoking reprograms immune cells to accelerate cardiovascular disease #atherosclerosis #blood #CardiovascularDisease #Cell #chemicals #Cholesterol #Chronic #Cigarette #Éire #Health #Heart #IE #ImmuneSystem #Inflammasome #inflammation #Interleukin #Ireland #Lungs #medicine #Neutrophils #Nicotine #pH #Research #smoking #Tobacco #WhiteBloodCell

https://www.europesays.com/uk/1054798/ Statins may trigger muscle side effects by activating inflammatory danger signals #Cell #cholesterol #Glycolysis #Health #Healthcare #heart #Inflammasome #leucine #Lipoprotein #Medication #muscle #MuscleAtrophy #Nucleotide #Protein #statin #Stress #Therapy #UK #UnitedKingdom

https://www.europesays.com/ie/554237/ Statins may trigger muscle side effects by activating inflammatory danger signals #Cell #Cholesterol #Éire #Glycolysis #Health #Healthcare #Heart #IE #Inflammasome #Ireland #Leucine #Lipoprotein #Medication #Muscle #MuscleAtrophy #nucleotide #Protein #Statin #Stress #therapy

Statins may trigger muscle side effects by activating inflammatory danger signals

New experimental findings reveal how statins may push vulnerable muscle cells into a stress state, suggesting future strategies…
#NewsBeep #News #Technology #AU #Australia #Cell #cholesterol #Glycolysis #Healthcare #Heart #Inflammasome #Leucine #Lipoprotein #Muscle #muscleatrophy #Nucleotide #protein #Statin #stress #therapy
https://www.newsbeep.com/au/754336/

Statins may trigger muscle side effects by activating inflammatory danger signals

New experimental findings reveal how statins may push vulnerable muscle cells into a stress state, suggesting future strategies…
#NewsBeep #News #Technology #AU #Australia #Cell #cholesterol #Glycolysis #Healthcare #Heart #Inflammasome #Leucine #Lipoprotein #Muscle #muscleatrophy #Nucleotide #protein #Statin #stress #therapy
https://www.newsbeep.com/au/754336/

Lactic acid drives #NLRP3 #inflammasome activation and caspase-1–like cytokine cleavage via intracellular acidification

https://www.nature.com/articles/s41419-026-08708-y #OpenAccess #immunology

Glibenclamide attenuates neuronal #pyroptosis by modulating KATP channels in the hippocampus of palmitic acid-induced lipotoxic mice

https://www.sciencedirect.com/science/article/pii/S2319417026000284 #OpenAccess #inflammasome #inflammation #immunology

Caspase-4 binds to #LPS membranes with positive curvature for non-canonical #inflammasome activation

https://www.sciencedirect.com/science/article/pii/S1074761325005734 #inflammation #immunity #immunology

New NIH grants fuel research in oral cancer treatment and pain relief

Researchers at the School of Denti…
#NewsBeep #News #Health #addiction #AU #Australia #Calcium #Cancer #CancerTreatment #carcinoma #Cell #DentalSchool #Dentistry #Drugs #Endodontics #Inflammasome #Inflammation #Ion #IonChannel #MouseModel #Mucositis #Neck #Nursing #oral #oralcancer #Pain #painmanagement #Radiotherapy #Receptor #research #SquamousCellCarcinoma #Therapeutics #Tumor #Xenograft
https://www.newsbeep.com/au/269995/

https://www.europesays.com/ie/168909/ New NIH grants fuel research in oral cancer treatment and pain relief #Addiction #Calcium #cancer #CancerTreatment #carcinoma #Cell #DentalSchool #Dentistry #Drugs #Éire #Endodontics #Health #IE #Inflammasome #inflammation #Ion #IonChannel #Ireland #MouseModel #Mucositis #Neck #Nursing #oral #OralCancer #Pain #PainManagement #radiotherapy #Receptor #Research #SquamousCellCarcinoma #Therapeutics #Tumor #Xenograft

Even with #antiretroviral therapy, HIV-1 can still cause persistent inflammation in macrophages. This study shows that intron-containing #HIV1 RNA (icRNA) activates NLRP1 #inflammasome & induces IL-1β secretion in myeloid cells, independent of RIG-I-like receptors @PLOSBiology https://plos.io/45VTGBR

Even with #antiretroviral therapy, HIV-1 can still cause persistent inflammation in macrophages. This study shows that intron-containing #HIV1 RNA (icRNA) activates NLRP1 #inflammasome & induces IL-1β secretion in myeloid cells, independent of RIG-I-like receptors @PLOSBiology https://plos.io/45VTGBR

Even with #antiretroviral therapy, HIV-1 can still cause persistent inflammation in macrophages. This study shows that intron-containing #HIV1 RNA (icRNA) activates NLRP1 #inflammasome & induces IL-1β secretion in myeloid cells, independent of RIG-I-like receptors @PLOSBiology https://plos.io/45VTGBR

Even with #antiretroviral therapy, HIV-1 can still cause persistent inflammation in macrophages. This study shows that intron-containing #HIV1 RNA (icRNA) activates NLRP1 #inflammasome & induces IL-1β secretion in myeloid cells, independent of RIG-I-like receptors @PLOSBiology https://plos.io/45VTGBR

Even with #antiretroviral therapy, HIV-1 can still cause persistent inflammation in macrophages. This study shows that intron-containing #HIV1 RNA (icRNA) activates NLRP1 #inflammasome & induces IL-1β secretion in myeloid cells, independent of RIG-I-like receptors @PLOSBiology https://plos.io/45VTGBR

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO

What is the mechanistic link between the NLRP3 #inflammasome, #autophagy & inflammatory #bowel disease (IBD)? This study shows that VANGL2 reduces #IBD progression by recruiting the ubiquitin ligase MARCH8 to regulate NLRP3 activation via OPTN-mediated autophagy plosbiology https://plos.io/42FTqFO

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80576

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=80142

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=79239

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

Postdoc in Inflammasome Signaling

University of Antwerp

See the full job description on jobRxiv: https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

#cell_biology #cell_death #immunology #inflammasome #Inflammation #mouse_models #signaling #ScienceJobs #hiring #research
https://jobrxiv.org/job/university-of-antwerp-27778-postdoc-in-inflammasome-signaling/?feed_id=78700

'Here, we show that Arachidonic Acid inhibits the NLRP3 inflammasome, through a PLC-JNK-dependent mechanism, to supress IL-1β production under physiological conditions. This provides a mechanistic basis for how dietary manipulation such as fasting influences the inflammatory state and is likely to be critical for reducing the metaflammation underpinning many diseases induced by the Western Diet.'
#Immunology #Inflammation #inflammasome #Metabolism

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00028-7

'Here, we show that Arachidonic Acid inhibits the NLRP3 inflammasome, through a PLC-JNK-dependent mechanism, to supress IL-1β production under physiological conditions. This provides a mechanistic basis for how dietary manipulation such as fasting influences the inflammatory state and is likely to be critical for reducing the metaflammation underpinning many diseases induced by the Western Diet.'
#Immunology #Inflammation #inflammasome #Metabolism

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00028-7

'Here, we show that Arachidonic Acid inhibits the NLRP3 inflammasome, through a PLC-JNK-dependent mechanism, to supress IL-1β production under physiological conditions. This provides a mechanistic basis for how dietary manipulation such as fasting influences the inflammatory state and is likely to be critical for reducing the metaflammation underpinning many diseases induced by the Western Diet.'
#Immunology #Inflammation #inflammasome #Metabolism

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00028-7

'Here, we show that Arachidonic Acid inhibits the NLRP3 inflammasome, through a PLC-JNK-dependent mechanism, to supress IL-1β production under physiological conditions. This provides a mechanistic basis for how dietary manipulation such as fasting influences the inflammatory state and is likely to be critical for reducing the metaflammation underpinning many diseases induced by the Western Diet.'
#Immunology #Inflammation #inflammasome #Metabolism

https://www.cell.com/cell-reports/fulltext/S2211-1247(24)00028-7

"Inflammasome-mediated caspase-1 activation facilitates innate immune control of Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria. However, caspase-1 processing occurs incompletely in both mouse and human hepatocytes and precludes the generation of mature IL-1β or IL-18, unlike in other cells. Why this is so or how it impacts Plasmodium control in the liver has remained unknown."
#Malaria #inflammasome

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300440/266573/Inherently-Reduced-Expression-of-ASC-Restricts?redirectedFrom=fulltext

"Inflammasome-mediated caspase-1 activation facilitates innate immune control of Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria. However, caspase-1 processing occurs incompletely in both mouse and human hepatocytes and precludes the generation of mature IL-1β or IL-18, unlike in other cells. Why this is so or how it impacts Plasmodium control in the liver has remained unknown."
#Malaria #inflammasome

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300440/266573/Inherently-Reduced-Expression-of-ASC-Restricts?redirectedFrom=fulltext

"Inflammasome-mediated caspase-1 activation facilitates innate immune control of Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria. However, caspase-1 processing occurs incompletely in both mouse and human hepatocytes and precludes the generation of mature IL-1β or IL-18, unlike in other cells. Why this is so or how it impacts Plasmodium control in the liver has remained unknown."
#Malaria #inflammasome

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300440/266573/Inherently-Reduced-Expression-of-ASC-Restricts?redirectedFrom=fulltext

"Inflammasome-mediated caspase-1 activation facilitates innate immune control of Plasmodium in the liver, thereby limiting the incidence and severity of clinical malaria. However, caspase-1 processing occurs incompletely in both mouse and human hepatocytes and precludes the generation of mature IL-1β or IL-18, unlike in other cells. Why this is so or how it impacts Plasmodium control in the liver has remained unknown."
#Malaria #inflammasome

https://journals.aai.org/jimmunol/article-abstract/doi/10.4049/jimmunol.2300440/266573/Inherently-Reduced-Expression-of-ASC-Restricts?redirectedFrom=fulltext

`Through unbiased analyses of #RNA and protein profiles in #Inositol polyphosphate-5-phosphatase D (INPP5D) -disrupted iPSC-derived human #microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted #autophagy and #inflammasome activation.. findings provide insights into the molecular mechanisms underlying microglia-mediated processes in #AD and highlight the inflammasome as a potential #therapeutic target`

https://www.nature.com/articles/s41467-023-42819-w

`Through unbiased analyses of #RNA and protein profiles in #Inositol polyphosphate-5-phosphatase D (INPP5D) -disrupted iPSC-derived human #microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted #autophagy and #inflammasome activation.. findings provide insights into the molecular mechanisms underlying microglia-mediated processes in #AD and highlight the inflammasome as a potential #therapeutic target`

https://www.nature.com/articles/s41467-023-42819-w

`Through unbiased analyses of #RNA and protein profiles in #Inositol polyphosphate-5-phosphatase D (INPP5D) -disrupted iPSC-derived human #microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted #autophagy and #inflammasome activation.. findings provide insights into the molecular mechanisms underlying microglia-mediated processes in #AD and highlight the inflammasome as a potential #therapeutic target`

https://www.nature.com/articles/s41467-023-42819-w

`Through unbiased analyses of #RNA and protein profiles in #Inositol polyphosphate-5-phosphatase D (INPP5D) -disrupted iPSC-derived human #microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted #autophagy and #inflammasome activation.. findings provide insights into the molecular mechanisms underlying microglia-mediated processes in #AD and highlight the inflammasome as a potential #therapeutic target`

https://www.nature.com/articles/s41467-023-42819-w

`Through unbiased analyses of #RNA and protein profiles in #Inositol polyphosphate-5-phosphatase D (INPP5D) -disrupted iPSC-derived human #microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted #autophagy and #inflammasome activation.. findings provide insights into the molecular mechanisms underlying microglia-mediated processes in #AD and highlight the inflammasome as a potential #therapeutic target`

https://www.nature.com/articles/s41467-023-42819-w

#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481

#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481

#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481

#MARCH5-dependent #NLRP3 #ubiquitination is required for #mitochondrial NLRP3-NEK7 complex formation and NLRP3 #inflammasome activation
https://www.embopress.org/doi/full/10.15252/embj.2023113481