#infetionimmunity — Public Fediverse posts

'Altogether, our study identifies an unappreciated site of Yersinia colonization within the murine intestinal mucosa, and reveals an essential function for inflammatory monocytes in maintainance of pyogranuloma architecture during Yp infection.'
fm @BrodskyLab et al

#InfetionImmunity #Plague #Yersinia #Immunology #InnateImmunity

https://www.nature.com/articles/s41564-023-01338-6

"Thus, studies of MSMD (Mendelian susceptibility to mycobacterial disease ) have revealed that human antimycobacterial immunity is a genetically controlled quantitative trait: the lower the level of IFN-γ activity, the more severe the disease and the higher its penetrance"

#immunology #InfetionImmunity #InfectiousDisease #mycobacterium #tuberculosis

https://www.cell.com/cell/fulltext/S0092-8674(22)01581-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422015811%3Fshowall%3Dtrue

'Virulence of C. difficile also has an intimate relationship with nutrient availability as, upon nutrient limitation in the gut environment, C. difficile responds by producing toxins that liberate host-derived nutrients through cytotoxic activity and creation of a proinflammatory environment'

#Clostridium #InfetionImmunity "Metabolism #Microbiology

https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011034

"Here, we investigated the fetal hematopoietic response to maternal infection with Toxoplasma gondii (T. gondii), an intracellular parasite that elicits Type II IFNγ-mediated maternal immunity."

#immunology #Parasitology #Toxoplasma #HostPathogen #InfetionImmunity #Preprint

https://www.biorxiv.org/content/10.1101/2022.11.29.518417v3

"By conducting a pangenomic screen of the plant pathogen #Pseudomonas syringae, we found 13 type III effectors that potentially possess NADase activities, indicating that NAD+ manipulation is an important virulence mechanism."

#HostPathogen #InfetionImmunity #Metabolism

https://www.pnas.org/doi/10.1073/pnas.2217114120