#immunopathology — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #immunopathology, aggregated by home.social.
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World’s first AI-designed vaccine explained https://theconversation.com/worlds-first-ai-designed-vaccine-explained-284668 #immunopathology #AI #health #science #STEM
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Type I interferon deficiency redirects antiviral immunity into NF-κB–driven inflammatory pathways, representing a maladaptive compensation that likely underlies the most common forms of virus-induced #immunopathology.
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Source: Cell Reports, https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01251-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2211124724012518%3Fshowall%3Dtrue
Summary
The coronavirus disease 2019 (COVID-19) pandemic has reminded us of human infections with the H7N9 virus and has raised questions related to the clinical and molecular pathophysiological diversity between the two diseases. Here, we performed a proteomic approach on sera samples from patients with H7N9-virus or SARS-CoV-2-virus infection and healthy controls. Compared to SARS-CoV-2, H7N9-virus infection caused elevated neutrophil concentrations, T cell exhaustion, and increased cytokine/interleukin secretion. Cell-type deconvolution and temporal analysis revealed that T cells and neutrophils could regulate the core immunological trajectory and influence the prognosis of patients with severe H7N9-virus infection. Elevated tissue-enhanced proteins combined with alterations of clinical biochemical indexes suggested that H7N9 infection induced more severe inflammatory organ injury and dysfunction in the liver and intestine. Further mechanical analysis revealed that the high concentration of neutrophils might impact the intestinal enterocyte cells through cytokine-receptor interaction, leading to intestinal damage in patients with H7N9-virus infection.____
#aH7n9 #abstract #AVIANINFLUENZA #covid #COVID19 #health #immunopathology #research #sarsCov2 #vaccine
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Defining the #balance between optimal #immunity and #immunopathology in #influenza virus #infection https://pubmed.ncbi.nlm.nih.gov/38698083/?utm_source=Feedly&utm_medium=rss&utm_campaign=None&utm_content=1fgJURi2yzLesFml6et0Bb6krzs_FrNIYgPYVFN50JPwVNFg9s&fc=None&ff=20240503023737&v=2.18.0.post9+e462414
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Pharmacological #inhibition of TBK1/IKKε blunts #immunopathology in a murine model of #SARS-CoV-2 infection https://www.nature.com/articles/s41467-023-41381-9 #research #science #covid19 #hyperinflammation
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Nice little study this, using SNPs in CCL19 & CCL21 linked with higher levels of these chemokines associated with greater #COVID19 infection and mortality.
Wonder if there's a mechanism. Greater #Neutrophil chemotaxis 👉 tissue pathology?
#IDMastodon #MedMastodon #immunopathology #immunology
CCL19 (rs3136658) and CCL21 (rs2812377) variants are associated with susceptibility and related mortality of SARS-CoV-2 infection: a population-based correlation analysis
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad032/7022103
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Didn't make the title, but higher IL-6 concentration associated with higher risk of hospitalisation.
(cause or effect 🤔)
#IDMastodon #MedMastodon #immunology #immunopathology #virology #virus #RSV