🧠 New preprint by Chintaluri et al. (2025): An ion channel #omnimodel for standardized #biophysical #neuron #modelling. A unified #HodgkinHuxley formalism applied to >3,500 ion channel models from #ModelDB. Enables cross-model comparison, #clustering, and reproducible simulation through a shared parametrization:
#hodgkinhuxley — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #hodgkinhuxley, aggregated by home.social.
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Oh Tx A!
What a pleasure reading classic pioneers humble candid remarks!
Contrast to nowadays endless new-papers new-models proposals without any scientific model self awareness on bias towards invalidation, and lacking such kind of remarks of owns models testable limitations, with such candid remarks alerts to fellow readers!Also from B. Katz, the other coauthor in one of the #HodgkinHuxley original quintet of seminal #compneuro papers!
Reminds of their 1952b that remarks:
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You might also enjoy this #neurolecture recalling #hodgkinhuxley #neurohistory seminal quintet of papers, remarking how became aware of their model limitations, written in the 1952 d/4th paper:
Forgotten lesson in nowadays #compneuro models research!
» wetlab interventionist experimentation must remain the principal activity in the search for neurobiological mechanisms, for the same reasons Hodgkin & Huxley realized nearly 70 years ago «
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An important step in #ComputationalNeuroscience 🧠💻 was the development of the #HodgkinHuxley model, for which Hodgkin and Huxley received the #NobelPrize in 1963. The model describes the dynamics of the #MembranePotential of a #neuron 🔬 by incorporating biophysiological properties. See here how it is derived, along with a simple implementation in #Python:
🌍 https://www.fabriziomusacchio.com/blog/2024-04-21-hodgkin_huxley_model/
Feel free to share and to experiment with the code.