#histones — Public Fediverse posts

Repressed but ready to go: How #bivalency holds developmental #genes in a poised state for #expression.

#histones #H3K27me3 #H3K4me3 #Nucleosome #KAT6B

https://phys.org/news/2025-02-repressed-ready-bivalency-developmental-genes.html

Repressed but ready to go: How #bivalency holds developmental #genes in a poised state for #expression.

#histones #H3K27me3 #H3K4me3 #Nucleosome #KAT6B

https://phys.org/news/2025-02-repressed-ready-bivalency-developmental-genes.html

🧬 Chemists discover new ways in which single-celled organisms organize their DNA

https://phys.org/news/2024-09-chemists-ways-celled-dna.html

#molbio #dna #prokaryotes #microbes #biology #bacteria #histones

🧬 Chemists discover new ways in which single-celled organisms organize their DNA

https://phys.org/news/2024-09-chemists-ways-celled-dna.html

#molbio #dna #prokaryotes #microbes #biology #bacteria #histones

🐙 These proteins have been secretly managing your cells

https://knowablemagazine.org/content/article/living-world/2024/histones-do-a-lot-more-than-regulate-genes

#biology #cells #molbio #histones

🐙 These proteins have been secretly managing your cells

https://knowablemagazine.org/content/article/living-world/2024/histones-do-a-lot-more-than-regulate-genes

#biology #cells #molbio #histones

.@Ansar_Karimian, Maria Vogelauer & @VashKurdistani discuss #PLOSBiology study which reveals #histones to be methyl group repositories in human cells, suggesting a role in optimizing cellular #methylation potential. Primer: https://plos.io/3QzVrwX Paper: https://plos.io/3MhUfM4

.@Ansar_Karimian, Maria Vogelauer & @VashKurdistani discuss #PLOSBiology study which reveals #histones to be methyl group repositories in human cells, suggesting a role in optimizing cellular #methylation potential. Primer: https://plos.io/3QzVrwX Paper: https://plos.io/3MhUfM4

How the #epigenetic landscape modulates pioneer #transcription factor binding.

#nucleosomes #Yamanaka #histones

https://phys.org/news/2023-05-epigenetic-landscape-modulates-transcription-factor.html

On this #ThrowbackThursday we go back to our Episode #49 there we caught up with Sandra Hake from the Justus Liebig University in Giessen to talk about her work on variants of core #histones and their role as modulators of #chromatin structure and function. #womeninstem #epigenetics

Listen here: https://www.activemotif.com/podcasts#sandra-hake

https://www.science.org/doi/10.1126/sciadv.adh0411

"We report a tightly regulated epigenome landscape change from the germline to embryos that are regulated through differential expression of distinct histone gene clusters. Together, this study reveals that a change from a H3.3- to H3-enriched epigenome during embryogenesis restricts developmental plasticity and uncovers distinct roles for individual H3 genes in regulating germline chromatin."

#epigenetics #devBio #developmentalBiology #chromosomes #chromatin #histones

"This work reveals epigenetic transmission of parental H2A-H2B during DNA replication and identifies cross talk between H3-H4 and H2A-H2B modifications in epigenome propagation. We propose that rapid short-term memory of recycled H2A-H2B modifications facilitates restoration of stable H3-H4 chromatin states."
https://www.cell.com/cell/fulltext/S0092-8674(23)00007-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423000077%3Fshowall%3Dtrue#:~:text=This%20work%20reveals,H4%20chromatin%20states.

#epigenetics #Histones #chromatin #cellularbiology #CellDivision #genomics

Amazing stuff - makes me immediately curious about genomic evolution of these microbes, and whether there's an observable difference in how chromosome - plasmid gene jumps happen in those situations.

Histone-organized chromatin in bacteria | bioRxiv
https://www.biorxiv.org/content/10.1101/2023.01.26.525422v1

#microbiology #histones

How do #yeast adapt to #chromatinization with human #histones and subsequent #aneuploidy?

Jeff Boeke, @maxhaase et al from NYU Langone find #ploidy stabilization by DASH/Dam1 complex mutants that weaken #kinetochore-#microtubule attachment strength

https://www.embopress.org/doi/10.15252/embj.2022112600

How do #yeast adapt to #chromatinization with human #histones and subsequent #aneuploidy?

Jeff Boeke, @maxhaase et al from NYU Langone find #ploidy stabilization by DASH/Dam1 complex mutants that weaken #kinetochore-#microtubule attachment strength

https://www.embopress.org/doi/10.15252/embj.2022112600

Just Published!

Epigenetics in Cancer Biology

https://link.springer.com/chapter/10.1007/16833_2022_86

#Cancer #CancerResearch #Epigenetics #DNAMethylation #RNAinterference #Histones #GeneExpression