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#herv — Public Fediverse posts

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  1. Jolene Invites: Hervé & Anastasia Kristensen @ Jolene - 06 Feb feat. Hervé, Anastasia Kristensen

    #SESH #Herv #AnastasiaKristensen

    sesh.sx/e/1622584

  2. new research article:
    Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging

    doi.org/10.1016/j.celrep.2023.

    "we verified the loss of B-type lamins inducing resurrection of ERVs as an initiating event of the aging-bound cascade in post-mitotic neurons. Of significance, these aging-related cellular and molecular changes can be alleviated by abacavir"

    #Brain #Aging #HERV #EndogenousRetrovirus
    #laminB #DrugRepurposing

  3. @sburall @SilverGorilla2 @HelenER

    I've heard about this study, it buzzed a lot! Frankly given my personal story of #MS, started when I was a child, after #varicella, I think there must be a missing link. I haven't found a better hypothesis explaining why MS is #progressive despite the best DMTs, other than the #HERV-w activation. Also I'm not sure that with a vaccine anti-ebv there would not be no more new cases of #MultipleSclerosis. We'll see.

  4. @sburall @SilverGorilla2 @HelenER

    I've heard about this study, it buzzed a lot! Frankly given my personal story of #MS, started when I was a child, after #varicella, I think there must be a missing link. I haven't found a better hypothesis explaining why MS is #progressive despite the best DMTs, other than the #HERV-w activation. Also I'm not sure that with a vaccine anti-ebv there would not be no more new cases of #MultipleSclerosis. We'll see.

  5. @sburall @SilverGorilla2

    And from the same link:

    " Over 95% of the world population have been infected by #EBV, and a much smaller percentage (thankfully) develop #MS or #LongCovid.

    The missing link may be #HERV-W ENV, whose expression is triggered in some individuals by EBV as well as by #SARS-CoV-2"

    Still many questions around this topic, that only clinicaltrials Can answers.

    #MSchat #PostCovid #LongCovid

  6. @sburall @SilverGorilla2

    And from the same link:

    " Over 95% of the world population have been infected by #EBV, and a much smaller percentage (thankfully) develop #MS or #LongCovid.

    The missing link may be #HERV-W ENV, whose expression is triggered in some individuals by EBV as well as by #SARS-CoV-2"

    Still many questions around this topic, that only clinicaltrials Can answers.

    #MSchat #PostCovid #LongCovid

  7. @sburall @SilverGorilla2
    Thank you.
    From 🔗🐦twitter.com/jesmartingarcia?t=

    "#HERV-W ENV is well documented both in #MS, triggered by #EBV and other #herpes family viruses, and in #COVID-19, triggered by #SARS-CoV-2. Very different patterns of of expression, but may indeed elucidate some of the similar features."

    My #MS was triggered by #varicella, an herpes family virus at the age 8

  8. @sburall @SilverGorilla2
    Thank you.
    From 🔗🐦twitter.com/jesmartingarcia?t=

    "#HERV-W ENV is well documented both in #MS, triggered by #EBV and other #herpes family viruses, and in #COVID-19, triggered by #SARS-CoV-2. Very different patterns of of expression, but may indeed elucidate some of the similar features."

    My #MS was triggered by #varicella, an herpes family virus at the age 8

  9. @SilverGorilla2 🙏
    I am not a scientist, I've read that the envelope protein of the #HERV-W #Retrovirus might be an aggravating factor in #MS and that it would also play a role in inflammatory #psychosis, as well as in min. 25% of #longcovid. All this has been published. Forseps.org has been following this trail for 10 years. A P2 trial with #temelimab targeting this protein is recruiting in 🇨🇭 Switzerland. The P2 in #MS had positive results, presented at #ECTRIMS2022#mschat

  10. @SilverGorilla2 🙏
    I am not a scientist, I've read that the envelope protein of the #HERV-W #Retrovirus might be an aggravating factor in #MS and that it would also play a role in inflammatory #psychosis, as well as in min. 25% of #longcovid. All this has been published. Forseps.org has been following this trail for 10 years. A P2 trial with #temelimab targeting this protein is recruiting in 🇨🇭 Switzerland. The P2 in #MS had positive results, presented at #ECTRIMS2022#mschat