Live and recent posts from across the Fediverse tagged #hematopoietic, aggregated by home.social.
Sharing a visualization from ongoing methodological work on chromatin domain architecture in aging hematopoiesis.
Figure: Age-Associated Broadening of H3K27me3 Domains Across Chromatin Contexts.
#Epigenetics #ChromatinBiology #PolycombRepressiveComplex #H3K27me3 #Hematopoietic
#RetinoicAcid (RA) regulates #hematopoietic homeostasis during development, but how? This study defines a Angptl5-Integrin α6lβ5-ERK axis that regulates RA signaling and restrains #myeloid & #erythroid progenitor expansion during zebrafish embryogenesis @PLOSBiology https://plos.io/4v2q3bk
Is the placenta is a source of, or merely a niche for, blood-forming #hematopoietic #StemCells? This Primer explores a #plosbiology study showing that the placenta does not directly give rise to hematopoietic stem cells. Paper: https://plos.io/4hl3qZF Primer: https://plos.io/40R1VeE
#Cordblood, rich in #hematopoietic #STEMcells, holds promise for treating a myriad of #diseases, including #blood disorders, #immune deficiencies, #metabolic diseases, and certain #cancers"
https://indianf.com/save-newborn-cord-blood-health-potential/#:~:text=Cord%20blood%2C%20rich%20in%20hematopoietic%20stem%20cells%2C%20holds%20promise%20for%20treating%20a%20myriad%20of%20diseases%2C%20including%20blood%20disorders%2C%20immune%20deficiencies%2C%20metabolic%20diseases%2C%20and%20certain%20cancers
Genetic Findings of Potential Donor Origin following #Hematopoietic Cell Transplantation: Recommendations on #Donor Disclosure and Genetic Testing from the World Marrow Donor Association (WMDA)
#wmda #htc #hematopoietic #marrow #bethematch #genetictesting #ethics
#stemcelltransplant #stemcell #CellularTherapy
https://www.astctjournal.org/article/S2666-6367(23)01708-6/fulltext
Bi-directional interplay between #metabolism and #epigenetics in #hematopoietic #stemcells and #leukemia
Nina Cabezas-Wallscheid and colleagues review #metabolic stress stimuli acting in the #bonemarrow as well as recent advances in their #therapeutic exploitation
https://www.embopress.org/doi/full/10.15252/embj.2022112348
#Hematopoietic #stemcells undergo a #lymphoid-to-#myeloid switch in early stages of emergency #granulopoiesis
Karolína Vaníčková, Meritxell Alberich-Jorda et al
https://www.embopress.org/doi/full/10.15252/embj.2023113527
Last session of the conference! Continuing theme of "Cell identity in situ"
Parker Côté, DFCI
in Li Lab
https://ki.mit.edu/people/clinical-investigators-research-fellows/hojun-li
The #transcriptional dynamics of human #hematopoiesis at #SingleCell resolution
do #StemCells and #ProgenitorCells in #hematopoietic system (#HSPC) change with age?
HSPCs exist on a continuum of cell types
They identified #GeneExpression programs active in uncommitted cells, looking across human development (fetal to aged)
Both maternal #IFNγ exposure and acute prenatal infection with #Toxoplasma gondii activate fetal #hematopoietic #stemcells
Anna E Beaudin and colleagues
https://www.embopress.org/doi/full/10.15252/embj.2022112693
#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer
#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer
#scRNAseq of 18,900 pre-leukemic & leukemic cells reveals transformation of #Hematopoietic #StemCells into full-blown #AcuteMyeloidLeukemia, emphasizing the critical role of #RNAsplicing in the emergence & maintenance of #leukemia #PLOSBiology https://plos.io/3LOnfer