#h5nx — Public Fediverse posts

Evolving #dynamics of #H5Nx avian #influenza in #China revealed by long-term wild bird #surveillance, https://etidiohnew.blogspot.com/2026/07/evolving-dynamics-of-h5nx-avian.html

The Winners Take It All? #Global Evolutionary #Success of #H5Nx #Reassortants in the 2020–2024 #Panzootic, https://etidiohnew.blogspot.com/2026/06/the-winners-take-it-all-global.html

#Niclosamide Inhibits the #Replication of Highly Pathogenic Avian #Influenza #H5Nx Viruses and Antiviral-Resistant #Mutants, https://etidiohnew.blogspot.com/2026/05/niclosamide-inhibits-replication-of.html

Cross-neutralizing and potent #human monoclonal #antibodies against historical and emerging #H5Nx #influenza viruses, https://etidiohnew.blogspot.com/2025/10/cross-neutralizing-and-potent-human.html

The Winners Take It All? Evolutionary #Success of #H5Nx #Reassortants in the 2020–2024 #Panzootic, https://etidiohnew.blogspot.com/2025/07/the-winners-take-it-all-evolutionary.html

Mapping #Haemagglutinin #Residues Driving #Antigenic Diversity in #H5Nx Avian #Influenza Viruses, https://etidiohnew.blogspot.com/2025/06/mapping-haemagglutinin-residues-driving.html

Investigating Factors Driving Shifts in Subtype #Dominance within #H5Nx Clade 2.3.4.4b High-Pathogenicity Avian #Influenza viruses, https://etidiohnew.blogspot.com/2025/05/investigating-factors-driving-shifts-in.html

The #receptor binding properties of #H5Nx #influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans, https://etidiohnew.blogspot.com/2025/04/the-receptor-binding-properties-of-h5nx.html

Investigating #Factors Driving Shifts in #Subtype #Dominance within #H5Nx Clade 2.3.4.4b High-Pathogenicity Avian #Influenza viruses, https://etidiohnew.blogspot.com/2025/04/investigating-factors-driving-shifts-in.html

Phylogenetic #discordance cannot identify #genomic #reassortment events: a case study with the avian #influenza virus #H5Nx, https://etidiohnew.blogspot.com/2025/03/phylogenetic-discordance-cannot.html

Recurring #incursions and #dissemination of novel #Eurasian-origin #H5Nx avian #influenza viruses in Atlantic #Canada, https://etidiohnew.blogspot.com/2024/12/recurring-incursions-and-dissemination.html

#Genotypic & #phenotypic susceptibility of emerging avian #influenza A viruses to
#NAIs & cap-dependent endonuclease #inhibitors, Antiviral Res.: https://www.sciencedirect.com/science/article/pii/S0166354224001682?via%3Dihub

Frequencies of markers of resistance to antivirals were low among >20,000 avian influenza A viruses studied. #H5Nx, #H7Nx, & #H9N2 viruses were susceptible to sub-nanomolar concentrations of antivirals. NA-I222M, but not NA-S246N or NA-I222V, in H5N1 confers reduced inhibition by #oseltamivir.

#Assessment of #Survival #Kinetics for Emergent Highly Pathogenic Clade 2.3.4.4 #H5Nx Avian #Influenza #Viruses, Viruses: https://www.mdpi.com/1999-4915/16/6/889

Statistical tests of the difference between the DT values and extinction times of each clade 2.3.4.4 strain at each #temperature indicated that the majority displayed different survival kinetics from the other strains at 4 °C and 20 °C.

#Seabird and sea #duck #mortalities were lower during the second breeding season in eastern #Canada following the introduction of Highly Pathogenic Avian #Influenza A #H5Nx viruses, BioRxIV, https://www.biorxiv.org/content/10.1101/2024.05.03.591923v1?rss=1

Mortalities in breeding season were 93% lower in 23 compared to 22 but encompassed a more diverse array of species. Mortalities in fall & winter (non-breeding season) were dominated by waterfowl, while mortalities during spring & summer (breeding season) were dominated by seabirds.

Characterization of high pathogenicity avian #influenza #H5Nx viruses from a wild harbor #seal and red #foxes in #Denmark, 2021 and 2022, https://www.ncbi.nlm.nih.gov/pmc/PMC10577164/?utm_source=Feedly&utm_medium=rss&utm_content=1LGAx__djGAJ9poBzWGqPtjEbBDtz4ipSRRPUplmgHEyyF_Ihj&ff=20231018064711&v=2.17.9.post6+86293ac #research #science #veterinary #epizootic #panzootic #zoonoses #EIDs

''Although #H5Nx viruses have been detected at higher rates in North #America since 2021, a #bidirectional flow of H5Nx genes of American origin viruses to #Europe has never been reported. In the future, coordinated and systematic surveillance programs for HPAI viruses need to be launched between European and North American agencies.''

''Highly pathogenic avian #influenza (HPAI) #H5Nx viruses can cause neurological #complications in many mammalian #species, including #humans.
Neurological disease induced by #HPAI H5Nx viruses in mammals can manifest without clinical respiratory disease.
HPAI H5Nx viruses are more #neuropathogenic than other influenza A viruses in mammals.
Severe neurological disease in mammals is related to the neuroinvasive and neurotropic potential of HPAI H5Nx viruses.''

The #neuropathogenesis of highly pathogenic #avian #influenza #H5Nx viruses in #mammalian species including #humans, Trends Neurosci., https://doi.org/10.1016/j.tins.2023.08.002 #epizootic #panzootic #zoonoses #EIDs #research #pandemic #pathology