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#gxe — Public Fediverse posts

Live and recent posts from across the Fediverse tagged #gxe, aggregated by home.social.

  1. Daniel E. Weeks @[email protected] ·

    STATGEN 2024 talk
    Distinct explanations underlie gene-environment interactions in the UK Biobank.
    Arun Durvasula

    Genetic effects across the genome may exhibit context dependence
    - European vs. East Asian genetic correlation is less than 1 across a wide range of traits.
    - Hinting at polygenic GxE

    GxE can arise through different scenarios
    - Imperfect genetic correlation
    - Varying genetic variance
    - Proportional amplification

    1/

    #Genetics #StatisticalGenetics #STATGEN2024 #GxE

    #genetics #statisticalgenetics #statgen2024 #gxe
  2. Daniel E. Weeks @[email protected] ·

    STATGEN 2024 talk
    A New Test for Trait Mean and Variance Detects Unreported Loci for Blood Pressure Variation
    Todd L. Edwards

    If there is a GxE, then variance of Y differs by genotype.

    If we don't know E, we can model both the mean & variance as function of the main predictor.

    Known a long time - e.g. Waddington (1942) Canalization of development and the inheritance of acquired characters.

    1/

    #Genetics #STATGEN2024 #GxE #StatisticalGenetics

    #genetics #statgen2024 #gxe #statisticalgenetics