#glycocalyx — Public Fediverse posts

https://www.europesays.com/ch-fr/105313/ La modification du glycocalyx stimule le ciblage des cellules immunitaires contre le lymphome B #cellules #ciblage #contre #des #glycocalyx #Health #immunitaires #Lymphome #modification #Santé #stimule #Suisse

https://www.europesays.com/be-fr/87291/ La modification du glycocalyx stimule le ciblage des cellules immunitaires contre le lymphome B #BE #BEFr #Belgique #Belgium #Cellules #ciblage #contre #des #glycocalyx #Health #immunitaires #Lymphome #modification #Santé #stimule

New Approach To Stopping Diabetic Blood Vessel Damage: An enzyme inhibitor drug stops vessel lining damage in the retina, kidneys, and other sites. #diabetes #eye #kidney #endothelial #heparanase #glycocalyx #ubristol
https://www.instagram.com/p/C3Gd8J9LAmk/

@rombarthelemy @BakkeHK Sorry, that was just a general comment on the psychological effect, not trying to argue against #albumin; quite the opposite!

Very interesting article and thank you for sharing it! Do you have any thoughts on timing and benefit, purely in terms of #glycocalyx damage?

Is the benefit of albumin constant regardless of the degree of existing glycocalyx damage? Or is there a point where, if the disruption is severe enough, it stops being effective?

@rombarthelemy @BakkeHK Sorry, that was just a general comment on the psychological effect, not trying to argue against #albumin; quite the opposite!

Very interesting article and thank you for sharing it! Do you have any thoughts on timing and benefit, purely in terms of #glycocalyx damage?

Is the benefit of albumin constant regardless of the degree of existing glycocalyx damage? Or is there a point where, if the disruption is severe enough, it stops being effective?

@rombarthelemy @BakkeHK Sorry, that was just a general comment on the psychological effect, not trying to argue against #albumin; quite the opposite!

Very interesting article and thank you for sharing it! Do you have any thoughts on timing and benefit, purely in terms of #glycocalyx damage?

Is the benefit of albumin constant regardless of the degree of existing glycocalyx damage? Or is there a point where, if the disruption is severe enough, it stops being effective?

@rombarthelemy @BakkeHK Sorry, that was just a general comment on the psychological effect, not trying to argue against #albumin; quite the opposite!

Very interesting article and thank you for sharing it! Do you have any thoughts on timing and benefit, purely in terms of #glycocalyx damage?

Is the benefit of albumin constant regardless of the degree of existing glycocalyx damage? Or is there a point where, if the disruption is severe enough, it stops being effective?

@razvan @BakkeHK Not at all. The purpose of using #albumin in #SepticShock is precisely to prevent or mitigate #glycocalyx damage. If oncontic pressure gradient was the purpose, any synthetic colloid would do the job (actually, they won’t, because of the altered endothelial layer, as you suggested)

https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00697-1

https://link.springer.com/article/10.1007/s00134-022-06740-y

@razvan @BakkeHK Not at all. The purpose of using #albumin in #SepticShock is precisely to prevent or mitigate #glycocalyx damage. If oncontic pressure gradient was the purpose, any synthetic colloid would do the job (actually, they won’t, because of the altered endothelial layer, as you suggested)

https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00697-1

https://link.springer.com/article/10.1007/s00134-022-06740-y

@razvan @BakkeHK Not at all. The purpose of using #albumin in #SepticShock is precisely to prevent or mitigate #glycocalyx damage. If oncontic pressure gradient was the purpose, any synthetic colloid would do the job (actually, they won’t, because of the altered endothelial layer, as you suggested)

https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00697-1

https://link.springer.com/article/10.1007/s00134-022-06740-y

@razvan @BakkeHK Not at all. The purpose of using #albumin in #SepticShock is precisely to prevent or mitigate #glycocalyx damage. If oncontic pressure gradient was the purpose, any synthetic colloid would do the job (actually, they won’t, because of the altered endothelial layer, as you suggested)

https://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00697-1

https://link.springer.com/article/10.1007/s00134-022-06740-y

Laura Hartmann ist seit 1. März 2023 Professorin für #MakromolekulareChemie. Ein Schwerpunkt ihrer Professur liegt auf der Erforschung aktiver weicher Materie, insbesondere sogenannter biomimetischer #Polymere.
Hartmann hat soeben einen Consolidator Grant des Europäischen Forschungsrats (ERC) erhalten. Die EU fördert damit ihre Forschung zur #Glycocalyx, der Zuckerschicht auf menschlichen Zellen.
http://uni-freiburg.link/hartmann-laura

Laura Hartmann ist seit 1. März 2023 Professorin für #MakromolekulareChemie. Ein Schwerpunkt ihrer Professur liegt auf der Erforschung aktiver weicher Materie, insbesondere sogenannter biomimetischer #Polymere.
Hartmann hat soeben einen Consolidator Grant des Europäischen Forschungsrats (ERC) erhalten. Die EU fördert damit ihre Forschung zur #Glycocalyx, der Zuckerschicht auf menschlichen Zellen.
http://uni-freiburg.link/hartmann-laura

Laura Hartmann ist seit 1. März 2023 Professorin für #MakromolekulareChemie. Ein Schwerpunkt ihrer Professur liegt auf der Erforschung aktiver weicher Materie, insbesondere sogenannter biomimetischer #Polymere.
Hartmann hat soeben einen Consolidator Grant des Europäischen Forschungsrats (ERC) erhalten. Die EU fördert damit ihre Forschung zur #Glycocalyx, der Zuckerschicht auf menschlichen Zellen.
http://uni-freiburg.link/hartmann-laura

Laura Hartmann ist seit 1. März 2023 Professorin für #MakromolekulareChemie. Ein Schwerpunkt ihrer Professur liegt auf der Erforschung aktiver weicher Materie, insbesondere sogenannter biomimetischer #Polymere.
Hartmann hat soeben einen Consolidator Grant des Europäischen Forschungsrats (ERC) erhalten. Die EU fördert damit ihre Forschung zur #Glycocalyx, der Zuckerschicht auf menschlichen Zellen.
http://uni-freiburg.link/hartmann-laura

Excited to share our work of the of the last 5 years. https://www.biorxiv.org/content/10.1101/2023.01.06.523012v1. We found that in response to the ISR, the primate-specific #lncRNA LISR customises the #ribosomes to drive translation of an immune suppressive signature. The signature includes #neoantigens translated from lncRNAs, the #immunecheckpoint receptor PDL1 and the #glycocalyx. LISR KD restores sensitivity to #immunecheckpointblockade in #melanoma and possibly in other cancers.

Excited to share our work of the of the last 5 years. https://www.biorxiv.org/content/10.1101/2023.01.06.523012v1. We found that in response to the ISR, the primate-specific #lncRNA LISR customises the #ribosomes to drive translation of an immune suppressive signature. The signature includes #neoantigens translated from lncRNAs, the #immunecheckpoint receptor PDL1 and the #glycocalyx. LISR KD restores sensitivity to #immunecheckpointblockade in #melanoma and possibly in other cancers.

At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)

At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)

At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)

At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)

At the #PrecapillarySphincter and #NeurovascularUnit, I show: #EndothelialCell, #MuralCell, #Fibroblast, #Macrophage, #Astrocyte and #Neuron. Also, structures: #ContractileElement, #MyoendothelialJunction, #PinocyticVesicle, #Collagen, #Elastin, #Glycocalyx (6/15)