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#gene-editing — Public Fediverse posts

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  1. Colossal Biosciences Is Making Jurassic Park Look Like a Pitch Deck

    Modern biotechnology labs are driving advances in gene editing and de-extinction research

    Dear Cherubs, Dallas has apparently decided extinction is just a product category. Colossal Biosciences is now a billionaire-level biotech spectacle, with the company saying its latest Series C brought total funding to $615 million and ABC News reporting a roster of celebrity backers that includes Tom Brady, Tiger Woods, Paris Hilton and Peter Jackson. Dallas Innovates also reported that the CIA’s venture arm, In-Q-Tel, invested in Colossal back in 2022.

    The result is a company that sounds like it was brainstormed by a film studio, a venture fund and a very committed science teacher. Colossal says it is working on de-extinction projects tied to the woolly mammoth, dodo, thylacine and dire wolf, using gene editing, synthetic biology and related conservation tools. So no, this is not literally Jurassic Park; it is more like Jurassic Park after legal review and a lot of grant money.

    THE TEA, BUT WITH MICROPIPETTES

    In April, Reuters reported that Colossal announced three genetically engineered wolf pups and called them the world’s first successfully “de-extincted” animals, while outside experts were more cautious and described them as genetically modified gray wolves with added dire-wolf traits. ABC News said Colossal edited gray wolf cells at multiple sites and noted the two species are about 99.5% genetically identical, which is a very impressive number and also a reminder that biology is rude and complicated.

    That is the key detail the movie version never pauses for: the company is not dusting off a frozen dinosaur and pressing play. It is using ancient DNA, gene editing and surrogate biology to create something that resembles an extinct species closely enough to trigger headlines, debates and a healthy amount of side-eye. The label “de-extincted” is doing a lot of heavy lifting here.

    WHY THE MONEY FLOWS

    The money makes more sense when you look at the technology stack. Dallas Innovates reported that In-Q-Tel said its interest in Colossal was “less about the mammoths and more about the capability,” while Colossal’s own materials say the work could scale CRISPR, synthetic biology, artificial wombs and genomic preservation platforms. In other words, the extinct-animal angle is the headline; the platform is the business.

    Colossal has also built a pop-culture-friendly halo around the science. Its advisory board page lists Tom Brady and George R.R. Martin among its cultural advisors, which is exactly the kind of sentence that makes the internet stop scrolling for a second. That is the trick here: make de-extinction feel part science, part blockbuster, part meme, and suddenly the cap table looks almost inevitable.

    The hot take is simple: this is not a cartoonish clone factory, and it is not pure hype either. It is a very expensive attempt to push gene editing, cloning-adjacent methods and reproductive tech into territory that could one day matter for conservation as much as spectacle. The dinosaurs are still fiction, but the lab bills are extremely real.

    Sources list
    ABC News — https://abcnews.go.com/US/dire-wolf-revived-biotech-companys-de-extinction-process/story?id=120558562
    Reuters — https://www.reuters.com/science/us-company-resurrects-extinct-dire-wolf-or-some-version-it-2025-04-08/
    Dallas Innovates — https://dallasinnovates.com/mammoth-interest-the-cia-invests-in-dallas-based-colossal-biosciences/
    Colossal Biosciences — https://colossal.com/colossal-secures-200m-to-accelerate-de-extinction-and-genomic-innovation/
    Colossal Biosciences — https://colossal.com/advisors/
    Wikimedia Commons (Laboratory.jpg) — https://commons.wikimedia.org/wiki/File:Laboratory.jpg

    The Thisclaimer logo blends a classic warning symbol with a brain icon to represent critical thinking, curiosity, and thoughtful disclaimers. #animals #biotechnology #cia #colossalBiosciences #crispr #deExtinction #direWolf #geneEditing #inQTel #nature #news #science #syntheticBiology #texasStartup
  2. Myrabello heißt der erste in Europa „gecrisperte“ Weißbüschelaffe. Mit ihm entstand ein #Tiermodell, das die #Therapie menschlicher #Taubheit auf völlig neue Weise erforschbar macht. Petra Neis-Beeckmann erzählt seine Geschichte: laborjournal.de/editorials/348 #CRISPR #Geneediting

  3. 🦠 Could we outsmart antibiotic resistance by turning bacteria against themselves?

    🔗 Rational Targeting and gRNA Design for Enhancing Quorum Quenching in Pseudomonas aeruginosa PAO1. Computational and Structural Biotechnology Journal (CSBJ). DOI: doi.org/10.34133/csbj.0089

    📚 CSBJ - A Science Partner Journal: spj.science.org/journal/csbj

    #AntimicrobialResistance #AMR #CRISPR #GeneEditing #SyntheticBiology #SystemsBiology #Microbiology #Biotechnology #DrugResistance #QuorumSensing #Biofilms #Genomics

  4. BACTERIAL EDITING TOOLBOX GAINS TRACTION ACROSS SPECIES

    Scientists created 'recombitrons' to edit bacterial DNA. This new tool works in 15 different bacteria types, offering a general way to change genes.

    #BacterialEditing, #Recombitrons, #GeneEditing, #Microbiology, #ScienceNews

    newsletter.tf/recombitron-tool

  5. 🎉 Wow, the #FDA finally figured out what genes are! 🧬 Their #groundbreaking #approval might just cure your hereditary inability to hear reason. 🤦‍♂️ Let's hope they can gene-edit their way to a solution for selective hearing next. 🙉
    fda.gov/news-events/press-anno #GeneEditing #HearingLoss #Innovation #HackerNews #ngated

  6. Two US Gene-Editing Startups for Embryos Shut Down Amid Funding and Legal Challenges

    📰 Original title: Designer Baby Companies Are in Turmoil

    🤖 IA: It's clickbait ⚠️
    👥 Usuarios: It's clickbait ⚠️

    View full AI summary: killbait.com/en/two-us-gene-ed

    #genetics #geneediting #embryos #biotechstartups

  7. "But to look at KJ’s case and conclude we’re ready to program pre-implantation embryos is like declaring you’re fluent in a new language because you’ve tried Duolingo."

    Abby Vesoulis for Mother Jones: motherjones.com/politics/2026/

    #Longreads #AI #Genetics #Eugenics #Science #Research #Tech #GeneEditing

  8. Pandemic (Jack Stapleton & Laurie Montgomery) "This extraordinary molecule can be custom-tailored to seek out and alter genes in plants or animals" Sale: $11.99 to $2.99 by Robin Cook Rating: 4.2/5 (3,233 Reviews) #MedicalThriller #GeneEditing #CRISPR #Thriller #BookSky

    Pandemic (Jack Stapleton & Lau...

  9. ✂️ Gene Editing - Mar 2026

    • YOLT-101 gene therapy cuts LDL cholesterol in familial hypercholesterolemia
    • Adenine base editors show enhanced on-target editing capabilities
    • TnpB editors surpass existing compact editors in plants
    • Evo 2 AI enhances genome editing prediction and design

    pir.sh/zZXgkQXd2M

    #GeneEditing #CRISPR #Biology

  10. 3 gene editing technologies transforming biology 🧬

    CRISPR-Cas9: targeted cutting → knockout or insertion

    Base editing: single-nucleotide changes, no double-strand breaks  

    Prime editing: insert, delete, or replace sequences with precision

    For aging research: correcting genetic changes, enhancing repair, engineering resilience

    #CRISPR #GeneEditing #Biotechnology #AgingResearch #PrecisionMedicine

  11. In an online survey in Spain (n=500), participants prioritised pesticide reduction when assessing potential benefits of #CRISPR. Two groups emerged: one motivated by environmental #sustainability, the other by health and sensory quality: doi.org/10.1186/s401... #GeneEditing #PlantBreeding #Health

    Which traits drive consumer pr...

  12. 🧬 CRISPR technology is transforming genetics 🔬, enabling precise gene editing for research, diagnostics, and future therapeutic innovations 🚀.

    #CRISPR #GeneEditing #Biotechnology #MolecularBiology #Cas9 #Genomics #LifeScienceStudents #ResearchInnovation #BiotechTrends #BioResire

  13. The Successor to CRISPR May Be Even More World Changing
    Gene editing just got an upgrade. We explore the breakthrough in "Prime Editing" and its successors that allow for more precise DNA modifications with fewer off-target effects. This technology is paving the way for permanent cures for genetic diseases that were previously thought untreatable.
    #CRISPR #GeneEditing #Biotech #HealthTech #Innovation #ScienceNews #FutureMedicine
    technology-news-channel.com/th

  14. Make your gene knockouts more efficient with multiplexed Cas12a sgRNAs. Our new paper is out now, with tools available from @[email protected] , www.plasmids.eu and @[email protected]. www.nature.com/articles/s41... #CRISPR #geneediting #Drosophila 🧪🧬✂️🔬🪰 Summary 🧵 below.

  15. Gene editing — Dec 2025 🧬

    Big moves beyond classic CRISPR:
    • In vivo editing of human stem cells
    • New Cas systems expand the toolbox
    • RNA editing without guide RNAs
    • Screens uncover drug-resistance pathways

    Full summary: pir.sh/pzy1bRB1lv

    #GeneEditing #CRISPR #GenomeEngineering #Biotech