🚨 Postdoc opportunity!
Passionate about theoretical & computational biology? Help map the #fitnesslandscape of #Fabry disease!
Join @iimog.sigmoid.social.ap.brid.gy, @sabinefischer & @gokhalecs.bsky.social at CCTB, @uni-wuerzburg.de
🔗 [PDF] tinyurl.com/mvr76my7
#Postdoc
tinyurl.com/fabry-postdoc
#fitnesslandscape — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #fitnesslandscape, aggregated by home.social.
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'An important aspect of this study is that we inferred the fitness landscape based on antibiotic resistance profiles and not genotypes. Although previous studies have focused on constructing fitness landscapes based on mutations for a few genes [4,6], because the number of possible genotype changes (e.g., nucleotide changes) associated with antibiotic resistance evolution is immense [32], empirical fitness landscapes based on genotypes were not capable of predicting/controlling evolution.'
#Evolution #EvolutionaryBiology #antibioticresistance #FitnessLandscape @PLOSBiology
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3001920#sec008
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New paper: How development affects evolution @journal_evo
https://academic.oup.com/evolut/advance-article/doi/10.1093/evolut/qpac003/6955321
#evolution #development #evodevo #Gmatrix #mathbio #plasticity #developmentalbias #nicheconstruction #extrageneticinheritance #senescence #ageing #evolutionarydynamics #adaptivedynamics #fitnesslandscape
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How is diversity maintained in a competitive arena (be it Darwinian or political), when intuitively one would expect a single optimal strategy to succeed over all others? In simulations, stable clusters occur when there is an advantage to being different per se. Such models could explain #SexualDimorphism, #ImmunogeneticVariation, or even #PoliticalParties. But confirming this empirically is a challenge.
#BalancingSelection #FitnessLandscape
#EvolutionarySimulation