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FANCM (PDB: 5V5X) — DEAD-box ATPase geometry (K1175/Mg²⁺) drives replication fork reversal at interstrand crosslinks, not classical duplex unwinding. Helicase–DNA interface: residues 1290–1297.
Fork reversal fidelity declines with age. FANCM's structural landscape is an underexplored target in replication stress and genomic aging.
#FANCM #FanconiAnemia #StructuralBiology #DNARepair #ReplicationStress #LongevityBiology #Biogerontology
New insights into alcohol-related DNA damage and cancer risk
Alcohol consumption leads to the formation of a toxic compound called acetaldehyde, which damages DNA. A research team…
#NewsBeep #News #Health #Alcohol #Anemia #biochemistry #Blood #CA #Canada #cancer #Cell #Compound #DNA #DNADamage #Enzyme #FanconiAnemia #Genetic #geneticinformation #Membrane #Nuclease #OrganicChemistry #research
https://www.newsbeep.com/ca/348163/
https://www.europesays.com/ie/235101/ New insights into alcohol-related DNA damage and cancer risk #Alcohol #Anemia #Biochemistry #blood #cancer #Cell #Compound #DNA #DNADamage #Éire #Enzyme #FanconiAnemia #Genetic #GeneticInformation #Health #IE #Ireland #Membrane #Nuclease #OrganicChemistry #Research
実は私、「白血病の方がマシ」と主治医に言わしめた #ファンコニ貧血 患者です（指定難病285 https://www.nanbyou.or.jp/entry/4442%EF%BC%89
#FanconiAnemia
#genetics #cancer #bonemarrow #DNArepair #Fanconianemia
Please check our review article, published in December Issue of Human Genetics.
Jasmine Peake and I wrote about Fanconi anemia, a genetic disorder with bone marrow failure and cancer predisposition. We discuss the genetics, phenotypic characteristics, epidemiology, and associated cancer risk of Fanconi anemia - also mechanisms of DNA repair via the Fanconi anemia DNA repair pathway.
https://link.springer.com/article/10.1007/s00439-022-02462-9