#exonuclease — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #exonuclease, aggregated by home.social.
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#WernerSyndrome mutations cause premature #aging, but what's the normal role of this #exonuclease? This study shows that the #Drosophila homolog WRNexo regulates the ER's #UnfoldedProteinResponse in intestinal #StemCells, promoting gut #regeneration after injury @PLOSBiology https://plos.io/42XBYfH
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"In conclusion, the newly identified PARP1-CTF18-Polϵ #exonuclease axis and HDR act independently to prevent fork collapse at single-ended double-strand breaks. #Olaparib inhibits this axis, explaining the pronounced #cytotoxic effects of olaparib on HDR-deficient cells."
https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad999/7369941
#polymerase #DNA #replication #mutations #cancer #oncology #cellBiology #genetics