#evolgenpaper — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #evolgenpaper, aggregated by home.social.
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Our new paper on long-term genetic threats to small populations finds that #MutationalMeltdown (bad mutations fixing) is less of a problem than "mutational drought" (too few good new mutations) @wmawass @uliseshmc @jdmatheson https://royalsocietypublishing.org/rspb/article/293/2072/20260600/481996/Extinction-vortices-are-driven-more-by-a-shortage #ConservationGenetics #EvolutionaryRescue #PopulationGenetics #EvolGenPaper 1/5
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Our new paper on long-term genetic threats to small populations finds that #MutationalMeltdown (bad mutations fixing) is less of a problem than "mutational drought" (too few good new mutations) @wmawass @uliseshmc @jdmatheson https://royalsocietypublishing.org/rspb/article/293/2072/20260600/481996/Extinction-vortices-are-driven-more-by-a-shortage #ConservationGenetics #EvolutionaryRescue #PopulationGenetics #EvolGenPaper 1/5
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Our new #preprint changes the way we look at an “extinction vortex” in which a small population loses fitness, causing it to become even smaller https://www.biorxiv.org/content/10.1101/2024.10.25.620329v1.
#MutationalMeltdown #EffectivePopulationSize #EvolutionaryRescue #PopulationGenetics #EvolGenPaper @wmawass @jdmatheson @uliseshmc 1/7 -
Our new #preprint changes the way we look at an “extinction vortex” in which a small population loses fitness, causing it to become even smaller https://www.biorxiv.org/content/10.1101/2024.10.25.620329v1.
#MutationalMeltdown #EffectivePopulationSize #EvolutionaryRescue #PopulationGenetics #EvolGenPaper @wmawass @jdmatheson @uliseshmc 1/7 -
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/ -
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/ -
Our latest #preprint https://ecoevorxiv.org/repository/view/6959/ explains why fitness can be defined in so many ways, and which version(s) you should use when. Fitness quantifies what #NaturalSelection favors. @gdoulcier #EvolGenPaper #Evolution 1/
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Our latest #preprint https://ecoevorxiv.org/repository/view/6959/ explains why fitness can be defined in so many ways, and which version(s) you should use when. Fitness quantifies what #NaturalSelection favors. @gdoulcier #EvolGenPaper #Evolution 1/
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Such a cool system. A fun project to work on. First DMI in maize I believe. And cool meiotic drive, sRNA, and teosinte introgression. #EvolgenPaper https://www.biorxiv.org/content/10.1101/2023.07.12.548689v1
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Such a cool system. A fun project to work on. First DMI in maize I believe. And cool meiotic drive, sRNA, and teosinte introgression. #EvolgenPaper https://www.biorxiv.org/content/10.1101/2023.07.12.548689v1
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Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper -
Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper -
Delighted to share our new Science #EvolgenPaper! https://www.science.org/doi/10.1126/science.abn3107
We introduce #TOGA, a #ComparativeGenomics method that combines the detection of orthologous genes with gene annotation. In plain words, TOGA can take advantage of a well-annotated #genome and transfer its annotations to a genome of a different species (e.g., from the human genome to that of a squirrel). 1/2
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Neat new #EvolgenPaper by @gvbarroso.
The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation:
https://peercommunityjournal.org/articles/10.24072/pcjournal.267/
Excited to sit down with this one!
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Neat new #EvolgenPaper by @gvbarroso.
The landscape of nucleotide diversity in Drosophila melanogaster is shaped by mutation rate variation:
https://peercommunityjournal.org/articles/10.24072/pcjournal.267/
Excited to sit down with this one!
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Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10 -
Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10 -
Out today in PNAS: "The paradox of adaptive trait clines with nonclinal patterns in the underlying genes" https://www.pnas.org/doi/full/10.1073/pnas.2220313120 This study shows that under complex multivariate adaptation, trait clines can evolve despite nonmonotonic allele frequency patterns across environmental gradients. These patterns are not discovered by genotype–environment association methods, which are widely used to discover adaptation. #EvolutionPaper #EcoEvo #SLiM #Genetics #Genomics #EvolgenPaper #PopGen
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Our latest #preprint develops a new metric of #CodonAdaptation (not just #CodonBias) to measure the kind of #EffectivePopulationSize that matters to #NearlyNeutralTheory, and uses it to discover that #NaturalSelection prefers high #IntrinsicStructuralDisorder https://www.biorxiv.org/content/10.1101/2023.03.02.530449v1 1/6
#MolecularEvolution #PopulationGenetics #EvolgenPaper -
Our latest #preprint develops a new metric of #CodonAdaptation (not just #CodonBias) to measure the kind of #EffectivePopulationSize that matters to #NearlyNeutralTheory, and uses it to discover that #NaturalSelection prefers high #IntrinsicStructuralDisorder https://www.biorxiv.org/content/10.1101/2023.03.02.530449v1 1/6
#MolecularEvolution #PopulationGenetics #EvolgenPaper -
New preprint by
Carl Veller and myself on the interpretation of population and family-based genome-wide association studies in the presence of confoundinghttps://www.biorxiv.org/content/10.1101/2023.02.26.530052v1
#GWAS interpretation is tricky, for three broad reasons: indirect effects of relatives, genetic confounding, and environmental confounding—where genetic confounding (long-distance LD) arises due to population structure, assortative mating, and selection. #EvolgenPaper
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New preprint by
Carl Veller and myself on the interpretation of population and family-based genome-wide association studies in the presence of confoundinghttps://www.biorxiv.org/content/10.1101/2023.02.26.530052v1
#GWAS interpretation is tricky, for three broad reasons: indirect effects of relatives, genetic confounding, and environmental confounding—where genetic confounding (long-distance LD) arises due to population structure, assortative mating, and selection. #EvolgenPaper
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Recently we also evaluated how well a widely-used method called "gradient forests" performs for the estimation of "genomic vulnerability". In this paper we highlight some strengths and weaknesses of the approach. Notably, genetic drift can cause small populations to have large "offset" values, highlighting issues with current interpretations and estimations. #EvolutionPaper #Evolution #EvolGenPaper https://onlinelibrary.wiley.com/doi/10.1111/eva.13354
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In our recent "Inversion Invasions" paper we studied the conditions under which inversions invade genomes and become involved in adaptation. We found that inversions were more likely to be involved in adaptation when the genetic basis of the adaptive trait was highly polygenic. #EvolgenPaper #EvolutionPaper #PopulationGenetics @royalsociety https://royalsocietypublishing.org/doi/10.1098/rstb.2021.0200 We developed this plot to visualize how inversions capture and gain genetic variation through time.
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Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5
#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper
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Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5
#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper
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Cool #preprint of #EvolutionaryBiology by Bohutínská et al: "Repeated adaptation to whole genome duplication in outcrossing Arabidopsis is mediated by mosaic adaptive haplotypes" #EvolgenPaper
https://www.biorxiv.org/content/10.1101/2023.01.11.523565v1 -
Cool #preprint of #EvolutionaryBiology by Bohutínská et al: "Repeated adaptation to whole genome duplication in outcrossing Arabidopsis is mediated by mosaic adaptive haplotypes" #EvolgenPaper
https://www.biorxiv.org/content/10.1101/2023.01.11.523565v1 -
These were later updated to be #EvolgenPaper #EvolutionPaper [and remember the internal caps] to avoid the underscores.
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These were later updated to be #EvolgenPaper #EvolutionPaper [and remember the internal caps] to avoid the underscores.
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#EvolgenPaper Synchronous effective population size changes and genetic stability of forest trees through glacial cycles https://www.biorxiv.org/content/10.1101/2023.01.05.522822v1
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#EvolgenPaper Synchronous effective population size changes and genetic stability of forest trees through glacial cycles https://www.biorxiv.org/content/10.1101/2023.01.05.522822v1
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Updated perspective piece on why human genetics should move away from using "genetic ancestry" groups as a sample description.
https://arxiv.org/abs/2207.11595
recirculating to start using hashtags
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Updated perspective piece on why human genetics should move away from using "genetic ancestry" groups as a sample description.
https://arxiv.org/abs/2207.11595
recirculating to start using hashtags
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OK sounds like #EvolgenPaper is good hashtag for adding to toots and threads on Evolutionary and Population Genetics papers
We could use #EvolutionPaper for papers more generally associated with Evolutionary Biology.
Please RT this and consider using these for tooting about papers, your own of those of others. That way we'll be able to keep track of them all more.
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OK sounds like #EvolgenPaper is good hashtag for adding to toots and threads on Evolutionary and Population Genetics papers
We could use #EvolutionPaper for papers more generally associated with Evolutionary Biology.
Please RT this and consider using these for tooting about papers, your own of those of others. That way we'll be able to keep track of them all more.
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We could also use #evolution_paper for the broader field. Open to other suggestions, eg if #EvolgenPaper #EvolutionPaper is easier (though if folks forget the caps they are less accessible).
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We could also use #evolution_paper for the broader field. Open to other suggestions, eg if #EvolgenPaper #EvolutionPaper is easier (though if folks forget the caps they are less accessible).