#evolgenpaper — Public Fediverse posts
Live and recent posts from across the Fediverse tagged #evolgenpaper, aggregated by home.social.
-
Our new #preprint changes the way we look at an “extinction vortex” in which a small population loses fitness, causing it to become even smaller https://www.biorxiv.org/content/10.1101/2024.10.25.620329v1.
#MutationalMeltdown #EffectivePopulationSize #EvolutionaryRescue #PopulationGenetics #EvolGenPaper @wmawass @jdmatheson @uliseshmc 1/7 -
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/ -
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/ -
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/ -
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/ -
Our latest paper https://elifesciences.org/articles/87335
directly measures the #EffectivePopulationSize that matters to #NearlyNeutralTheory / #DriftBarrier theory, as the degree to which #CodonBias differs from expectations from GC content. Surprisingly, stronger #NaturalSelection -> higher #IntrinsicStructuralDisorder proteins
#MolecularEvolution #PopulationGenetics #EvolgenPaper 1/ -
Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper -
Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper -
Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper -
Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper -
Our preprint describes how #EffectivePopulationSize affects #AminoAcid usage. https://www.biorxiv.org/content/10.1101/2023.02.01.526552v2. Within highly exchangeable pairs of amino acids, high Ne species are able to prefer #arginine over #lysine, and #valine over #isoleucine. This matches #thermophile preferences, as expected from theories of marginal protein stability at mutation-selection-drift balance. 1/6
@hanonmcshea #NearlyNeutralTheory #MolecularEvolution #EvolgenPaper -
Delighted to share our new Science #EvolgenPaper! https://www.science.org/doi/10.1126/science.abn3107
We introduce #TOGA, a #ComparativeGenomics method that combines the detection of orthologous genes with gene annotation. In plain words, TOGA can take advantage of a well-annotated #genome and transfer its annotations to a genome of a different species (e.g., from the human genome to that of a squirrel). 1/2
-
Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10 -
Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10 -
Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10 -
Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10 -
Our extensively revised preprint now goes beyond clarifying Haldane’s arguments about the #CostOfSelection / #SubstitutionalLoad / #SelectiveDeaths, it also significantly extends them, and applies the resulting model to data https://www.biorxiv.org/content/10.1101/2021.11.01.466728v2
@jdmatheson @moi #EvolgenPaper #PopulationGenetics #NaturalSelection #FitnessComponents #GeneticLoad 1/10 -
Our latest #preprint develops a new metric of #CodonAdaptation (not just #CodonBias) to measure the kind of #EffectivePopulationSize that matters to #NearlyNeutralTheory, and uses it to discover that #NaturalSelection prefers high #IntrinsicStructuralDisorder https://www.biorxiv.org/content/10.1101/2023.03.02.530449v1 1/6
#MolecularEvolution #PopulationGenetics #EvolgenPaper -
Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5
#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper
-
Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5
#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper
-
Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5
#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper
-
Our latest #preprint https://www.biorxiv.org/content/10.1101/2022.01.11.475913v2 @jdmatheson calls for significant change to the theory of #BackgroundSelection, a phenomenon by which some genomic segments of some individuals don’t count toward an #EffectivePopulationSize because they contain too many deleterious mutations. 1/5
#MolecularEvolution #PopulationGenetics #MutationLoad #EvolgenPaper