#erythromycin — Public Fediverse posts

A non-antibiotic erythromycin derivative improves muscle endurance by regulating endogenous anti-fatigue protein orosomucoid in mice [2024]

abstract:
https://pubmed.ncbi.nlm.nih.gov/38815994/

preprint download:
https://www.researchgate.net/publication/374021571_A_non-antibiotic_erythromycin_derivative_improves_muscle_endurance_by_regulating_endogenous_anti-fatigue_protein_orosomucoid/fulltext/65099cb1d5293c106cc89292/A-non-antibiotic-erythromycin-derivative-improves-muscle-endurance-by-regulating-endogenous-anti-fatigue-protein-orosomucoid.pdf

#orosomucoid #fatigue #erythromycin #DrugDevelopment

Erythromycin has therapeutic efficacy on muscle fatigue acting specifically on orosomucoid to increase muscle bioenergetics and physiological parameters of endurance [2020]

abstract:
https://pubmed.ncbi.nlm.nih.gov/32777256/

preprint can be downloaded here:
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3463265

#orosomucoid #fatigue #erythromycin #DrugRepurposing #DrugDevelopment

A recent review of the evidence on #erythromycin for #gastroparesis from the NHS’ Specialist Pharmacy Service: https://www.sps.nhs.uk/articles/what-is-the-optimal-prokinetic-dose-of-erythromycin-in-adults-2/

TL;DR: “Long term oral use is limited by poor tolerance, modest efficacy and the development of tachyphylaxis (rapidly diminishing response to drug therapy).”

My GP prescribed it to me so I’ll give it a shot, but I won’t stay on it. It also interacts with diazepam, to which I’m very sensitive because of physical dependence.

#MECFS #pwME #NEISvoid